Results 41 to 50 of about 179,880 (310)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
PACIFIC WALRUS PROTECTION AND MANAGEMENT IN A CHANGING CLIMATE
BRICS Law Journal, 2017 This article identifies and evaluates strategies and policies for walrus management in both Chukotka and Alaska. As the climate and walrus migration continue to change, it is important to follow adaptable strategies that are not fixed to specific ...
E. Ristroph
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Avian Conservation and Ecology, 2021 The decline of aerial insectivorous birds has been hypothesized to stem, in part, from a decline in aerial arthropod prey, underscoring the need for long-term monitoring of both bird and arthropod populations.
Adam Haberski +4 more
doaj
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
, 2020 The Alaska State Constitution, ratified by the people in 1956, became operative with the proclamation of statehood on January 3, 1959. The constitution was drafted by fifty-five delegates who convened at the University of Alaska to determine the ...
Alaska, enacting jurisdiction +1 more
core
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Alaskan English: Сontexts and conditions of emergence
Russian Journal of LinguisticsAlaskan English (AE), or the regional variety of English used by Native Alaskans, is a unique yet largely underinvestigated phenomenon. Specific conditions in which Alaskan English and its distinct characteristics have emerged remain significantly ...
Anastasia A. Grigoryeva +1 more
doaj +1 more source
Alaskan wild food harvester information needs and climate adaptation strategies
Ecology and Society, 2021 Changing biophysical conditions due to amplified climate change in northern latitudes has significant implications for species' habitat and populations and can dramatically alter interactions between harvesters and local resources.
Casey L. Brown +3 more
doaj +1 more source