Results 11 to 20 of about 38,275 (219)

Impact of anthelminthic treatment in pregnancy and childhood on immunisations, infections and eczema in childhood: a randomised controlled trial. [PDF]

PLoS ONE, 2012
BackgroundHelminth infections may modulate immune responses to unrelated pathogens and allergens; these effects may commence prenatally. We addressed the hypothesis that anthelminthic treatment in pregnancy and early childhood would improve responses to ...
Juliet Ndibazza, Harriet Mpairwe, Emily L Webb, Patrice A Mawa, Margaret Nampijja, Lawrence Muhangi, Macklyn Kihembo, Swaib A Lule, Diana Rutebarika, Barbara Apule, Florence Akello, Hellen Akurut, Gloria Oduru, Peter Naniima, Dennison Kizito, Moses Kizza, Robert Kizindo, Robert Tweyongere, Katherine J Alcock, Moses Muwanga, Alison M Elliott   +20 more
doaj   +6 more sources

A cell-based screen reveals that the albendazole metabolite, albendazole sulfone, targets Wolbachia. [PDF]

PLoS Pathogens, 2012
Wolbachia endosymbionts carried by filarial nematodes give rise to the neglected diseases African river blindness and lymphatic filariasis afflicting millions worldwide.
Laura R Serbus, Frederic Landmann, Walter M Bray, Pamela M White, Jordan Ruybal, R Scott Lokey, Alain Debec, William Sullivan   +7 more
doaj   +2 more sources

Efficacy and safety of nitazoxanide, albendazole, and nitazoxanide-albendazole against Trichuris trichiura infection: a randomized controlled trial. [PDF]

PLoS Neglected Tropical Diseases, 2012
The currently used anthelmintic drugs, in single oral application, have low efficacy against Trichuris trichiura infection, and hence novel anthelmintic drugs are needed. Nitazoxanide has been suggested as potential drug candidate.The efficacy and safety
Benjamin Speich, Shaali M Ame, Said M Ali, Rainer Alles, Jan Hattendorf, Jürg Utzinger, Marco Albonico, Jennifer Keiser   +7 more
doaj   +3 more sources

Investigating a Soluble Pharmaceutical Salt: Albendazole Hydrochloride

Crystal Growth & Design, 2019
Albendazole is an effective antihelmintic drug, which has an unpredictable therapeutic response due to its low solubility in biological fluids that limits its oral absorption.
Agustina Bongioanni, M. S. Bueno, Julieta Abraham-Miranda, A. Chattah, A. Ayala, M. Longhi, C. Garnero   +6 more
semanticscholar   +2 more sources

Different gut microbial communities correlate with efficacy of albendazole-ivermectin against soil-transmitted helminthiases

Nature Communications, 2022
Soil-transmitted helminth infections represent a large burden with over a quarter of the world’s population at risk. Low cure rates are observed with standard of care (albendazole); therefore, a more effective combination therapy (albendazole and ...
P. H. Schneeberger, M. Gueuning, S. Welsche, Eveline Hürlimann, J. Dommann, Cécile Häberli, J. Frey, S. Sayasone, J. Keiser   +8 more
semanticscholar   +1 more source

Efficacy and safety of moxidectin and albendazole compared with ivermectin and albendazole coadministration in adolescents infected with Trichuris trichiura in Tanzania: an open-label, non-inferiority, randomised, controlled, phase 2/3 trial

Lancet. Infectious Diseases (Print), 2022
Summary Background Control efforts against soil-transmitted helminths focus on preventive chemotherapy with albendazole and mebendazole, however these drugs yield unsatisfactory results against Trichuris trichiura infections.
S. Welsche, Emmanuel C. Mrimi, J. Hattendorf, Eveline Hürlimann, S. Ali, J. Keiser   +5 more
semanticscholar   +1 more source

Study on albendazole dispersible tablets based on solubilization effect

Journal of Hebei University of Science and Technology, 2021
In order to improve the dissolution properties of albendazole and solve the problem of dysphagia caused by conventional tablets in patients,the prescription and preparation process of albendazole dispersible tablets were explored based on the ...
Yinghua XIE, Dongmei ZHANG, Yu HAN, Qianhan LI, Xiaobin LIU, Qianqian YANG, Zhiwei LI   +6 more
doaj   +1 more source

Efficacy and safety of co-administered ivermectin and albendazole in school-aged children and adults infected with Trichuris trichiura in Côte d'Ivoire, Laos, and Pemba Island, Tanzania: a double-blind, parallel-group, phase 3, randomised controlled trial.

Lancet. Infectious Diseases (Print), 2021
BACKGROUND Preventive chemotherapy with albendazole or mebendazole remains one of the cornerstones of soil-transmitted helminth control. However, these drugs are less effective against Trichuris trichiura.
Eveline Hürlimann, Ladina Keller, Chandni Patel, S. Welsche, J. Hattendorf, S. Ali, S. Ame, S. Sayasone, J. Coulibaly, J. Keiser   +9 more
semanticscholar   +1 more source

THERAPEUTIC EFFICACY OF LACTOFERRIN LOADED ON NANO-PARTICLES IN TRICHINELLA SPIRALIS INFECTION IN MICE [PDF]

Journal of the Egyptian Society of Parasitology, 2023
Trichinellosis is a worldwide risky parasitic zoonosis caused by a nematode of the genusTrichinella. Anthelmintic such as albendazole and mebendazole commonly used to treat trichinellosisare badly water soluble and exhibit unfavorable bioavailability ...
MARWA NAGUIB, AZZA EL HAMSHARY, IBRAHIM BAOUMI, AZZA MAREI, MAHA FAWZY, AMIRA EL-GHANNAM   +5 more
doaj   +1 more source

Secretion into Milk of the Main Metabolites of the Anthelmintic Albendazole Is Mediated by the ABCG2/BCRP Transporter

Antimicrobial Agents and Chemotherapy, 2022
Albendazole (ABZ) is an anthelmintic with a broad-spectrum activity, widely used in human and veterinary medicine. ABZ is metabolized in all mammalian species to albendazole sulfoxide (ABZSO), albendazole sulfone (ABZSO2) and albendazole 2-aminosulphone (
Esther Blanco-Paniagua, Laura Álvarez-Fernández, A. M. Garcia-Lino, A. Álvarez, G. Merino   +4 more
semanticscholar   +1 more source