Results 11 to 20 of about 17,165 (261)

Efficacy and safety of as-needed albuterol/budesonide versus albuterol in adults and children aged ≥4 years with moderate-to-severe asthma: rationale and design of the randomised, double-blind, active-controlled MANDALA study

BMJ Open Respiratory Research, 2021
Introduction Uncontrolled asthma is associated with substantial morbidity. While fast-acting bronchodilators provide quick relief from asthma symptoms, their use as rescue fails to address the underlying inflammation.
Alberto Papi, Bradley E Chipps, Frank C Albers, Laurence Reilly, Eva Johnsson, Christy Cappelletti   +5 more
doaj   +2 more sources

Effects of the ß2-adrenoceptor agonist, albuterol, in a mouse model of anti-MuSK myasthenia gravis. [PDF]

PLoS ONE, 2014
The β2-adrenergic receptor agonist, albuterol, has been reported beneficial in treating several forms of congenital myasthenia. Here, for the first time, we examined the potential benefit of albuterol in a mouse model of anti-Muscle Specific Kinase (MuSK)
Nazanin Ghazanfari, Marco Morsch, Nigel Tse, Stephen W Reddel, William D Phillips   +4 more
doaj   +2 more sources

Historical cohort study examining comparative effectiveness of albuterol inhalers with and without integrated dose counter for patients with asthma or chronic obstructive pulmonary disease

Journal of Asthma and Allergy, 2016
David B Price,1,2 Anna Rigazio,2 Mary Buatti Small,3 Thomas J Ferro,3 1Academic Primary Care, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK; 2Research in Real-Life Ltd, Cambridge, UK; 3Teva Pharmaceuticals, Frazer, PA, USA ...
Price DB, Rigazio A, Buatti Small M, Ferro TJ   +3 more
doaj   +2 more sources

Albuterol-Budesonide Fixed-Dose Combination Rescue Inhaler for Asthma.

New England Journal of Medicine, 2022
BACKGROUND As asthma symptoms worsen, patients typically rely on short-acting β2-agonist (SABA) rescue therapy, but SABAs do not address worsening inflammation, which leaves patients at risk for severe asthma exacerbations.
A. Papi, B. Chipps, R. Beasley, R. Panettieri, E. Israel, M. Cooper, L. Dunsire, A. Jeynes-Ellis, E. Johnsson, R. Rees, C. Cappelletti, F. Albers   +11 more
semanticscholar   +1 more source

Nebulized in-line endotracheal dornase alfa and albuterol administered to mechanically ventilated COVID-19 patients: A case series

Molecular Medicine, 2020
Mechanically ventilated patients with COVID-19 have a mortality of 24–53%, in part due to distal mucopurulent secretions interfering with ventilation. DNA from neutrophil extracellular traps (NETs) contribute to the viscosity of mucopurulent secretions ...
Andrew Weber, A. Chau, M. Egeblad, B. Barnes, T. Janowitz   +4 more
semanticscholar   +2 more sources

For which infants with viral bronchiolitis could it be deemed appropriate to use albuterol, at least on a therapeutic trial basis?

Allergologia et Immunopathologia, 2021
Although there is increasing evidence showing that infants with viral bronchiolitis exhibit a high degree of heterogeneity, a core uncertainty shared by many clinicians is with regard to understanding which patients are most likely to benefit from ...
C. Rodríguez‐Martínez, G. Nino, J. Castro-Rodriguez, R. Acuña-Cordero, Mónica P. Sossa-Briceño, F. Midulla   +5 more
semanticscholar   +1 more source

Ensuring Access to Albuterol in Schools: From Policy to Implementation. An Official ATS/AANMA/ALA/NASN Policy Statement

American Journal of Respiratory and Critical Care Medicine, 2021
Rationale: For children with asthma, access to quick-relief medications is critical to minimizing morbidity and mortality. An innovative and practical approach to ensure access at school is to maintain a supply of stock albuterol that can be used by any ...
A. Volerman, A. Lowe, A. Pappalardo, Charmayne Anderson, K. Blake, T. Bryant-Stephens, Thomas Carr, Heather K Carter, L. Cicutto, J. Gerald, Tina Miller, Nuala S Moore, Hanna Phan, S. C. Sadreameli, Andrea Tanner, T. Winders, L. Gerald   +16 more
semanticscholar   +1 more source

Drug repurposing for COVID-19 using graph neural network and harmonizing multiple evidence [PDF]

Sci Rep 11, 23179 (2021), 2020
Amid the pandemic of 2019 novel coronavirus disease (COVID-19) infected by SARS-CoV-2, a vast amount of drug research for prevention and treatment has been quickly conducted, but these efforts have been unsuccessful thus far. Our objective is to prioritize repurposable drugs using a drug repurposing pipeline that systematically integrates multiple SARS-
arxiv   +1 more source

Effect of Nebulized Magnesium vs Placebo Added to Albuterol on Hospitalization Among Children With Refractory Acute Asthma Treated in the Emergency Department: A Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2020
Importance While intravenous magnesium decreases hospitalizations in refractory pediatric acute asthma, it is variably used because of invasiveness and safety concerns.
S. Schuh, J. Sweeney, Maggie Rumantir, A. Coates, A. Willan, D. Stephens, E. Atenafu, Y. Finkelstein, G. Thompson, R. Zemek, A. Plint, J. Gravel, F. Ducharme, David W Johnson, K. Black, Sarah Curtis, Darcy L Beer, T. Klassen, Darcy Nicksy, S. Freedman   +19 more
semanticscholar   +1 more source

(R)-albuterol decreases immune responses: role of activated T cells

Respiratory Research, 2008
Racemic albuterol is an equimolar mixture of two isomers, (R) and (S). Whether (R) and (S) isomers and the combination of both exert different effects in immune activation is not well defined. We analyzed the effects of (R+S)-albuterol, (R)-albuterol and
Lu Xin, He Hong, Jen Kai, Gordon Erin L, Ferrada Marcela A, Barone Leesa M, Amirifeli Sepideh, Perkins David L, Finn Patricia W   +8 more
doaj   +1 more source