Long-acting β2 agonist (LABA) with a long-acting muscarinic receptor antagonist (LAMA) promotes human airway smooth muscle (HASM) relaxation and circumvents β2 adrenergic receptor tachyphylaxis [PDF]
Respiratory ResearchTo fill the gap in the knowledge between clinical studies and pre-clinical mechanistic studies using combined LABA/LAMA therapy, we hypothesized that the combination is more effective in attenuating excitation-contraction (E-C) coupling compared to ...
Joseph Jude +5 more
doaj +2 more sources
Estimating the Effects of Continuous Albuterol Dosage on Clinical Outcomes for Pediatric Critical Asthma Exacerbation: A Retrospective Cohort Study. [PDF]
Pediatr PulmonolRiggins DP +5 more
europepmc +3 more sources
Dexmedetomidine as an adjunctive treatment for acute asthma [PDF]
Clinical and Experimental Emergency Medicine, 2021 Objective This study aimed to compare the efficacy of using dexmedetomidine with salbutamol and salbutamol nebulization alone in patients with acute exacerbation of asthma presenting to the emergency department.
Hassan Motamed +3 more
doaj +1 more source
BMC Health Services Research, 2022 Background Oral albuterol has worse efficacy and side effects compared with inhaled albuterol, and thus its use has been discouraged for decades. Drug inclusion or exclusion on formularies have been associated with reductions in low-value care.
Anna Volerman +4 more
doaj +1 more source
β2-Agonists inhibit TNF-α-induced ICAM-1 expression in human airway parasympathetic neurons. [PDF]
PLoS ONE, 2012 Major basic protein released from eosinophils to airway parasympathetic nerves blocks inhibitory M(2) muscarinic receptors on the parasympathetic nerves, increasing acetylcholine release and potentiating reflex bronchoconstriction.
Zhenying Nie +2 more
doaj +1 more source
Epigenomic response to albuterol treatment in asthma-relevant airway epithelial cells
Clinical Epigenetics, 2023 Background Albuterol is the first-line asthma medication used in diverse populations. Although DNA methylation (DNAm) is an epigenetic mechanism involved in asthma and bronchodilator drug response (BDR), no study has assessed whether albuterol could ...
Javier Perez-Garcia +16 more
doaj +1 more source
Associations of Community Material Neighborhood Deprivation With the Diagnosis of Asthma Among Infants With Bronchopulmonary Dysplasia (BPD). [PDF]
Pediatr PulmonolABSTRACT Objective To quantify associations of the community‐level material deprivation index (CMDI) with asthma diagnosis by age 5 years among preterm infants with bronchopulmonary dysplasia (BPD). Methods We conducted a retrospective cohort study of preterm infants with BPD, born between 2010 and 2019, discharged from a single hospital system to a ...
Szeto JJ +12 more
europepmc +2 more sources
Nebulized heparin and salbutamol versus salbutamol alone in acute exacerbations of chronic obstructive pulmonary disease requiring mechanical ventilation: a double-blind randomized controlled trial [PDF]
Korean Journal of Anesthesiology, 2020 Background Nebulized heparin has been effectively used in the management of many pulmonary diseases. However, its effect on mechanically ventilated patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD) has never been studied ...
Tarek Mohamed Ashoor +2 more
doaj +1 more source
Albuterol, Acidosis, and Aneurysms [PDF]
Federal Practitioner, 2021 A patient with a complicated medical history on admission for dyspnea was administered nebulizer therapy but after 72 hours developed asymptomatic acute kidney injury and anion-gap metabolic acidosis.
Lucy, Ma +2 more
openaire +2 more sources