Results 181 to 190 of about 641,640 (263)

From static labels to dynamic trajectories: MASLD-MetALD-ALD as a dynamic continuum within the framework of steatotic liver disease. [PDF]

eGastroenterology
Chen L, Horn P, Tacke F.
europepmc   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Anticonvulsant drugs for alcohol-related disorders

Medycyna Ogólna i Nauki o Zdrowiu
Alicja Góral, Michał Czachajda, Krystian Żuk, Kamila Duszyńska, Karol Dolepski, Marta Lis-Sochocka   +5 more
openaire   +2 more sources

A New Customizable Surfactant LLPS Strategy for Sustainable and Highly Efficient Radioactive Metal Ion Separation

Advanced Science, EarlyView.
A diluent‐free, customizable liquid–liquid phase separation (LLPS) platform enables highly efficient radioactive metal ion extraction and stripping. By encapsulating hydrophobic extractants into an ionic surfactant‐rich condensed phase, this LLPS system leverages synergistic electrostatic and coordination interactions.
Ruihan Yan, Yifu Hu, Wentao Wang, Zhi Cao, Meiwen Cao, Weifang Zheng, Guoan Ye, Taihong Yan   +7 more
wiley   +1 more source

Implementation of evidence-based alcohol policies to reduce alcohol-related harm and liver disease to advance public health in Europe. [PDF]

Lancet Reg Health Eur
Pose E, Díaz LA, Parker R, Israelsen M, Marjot T, Forrest E, Dhanda A, Paradis C, Arab JP, Krag A, Bataller R, Murray F, Lazarus JV, Carrieri P, Brennan PN.   +14 more
europepmc   +1 more source

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

Advanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao, Huanjie Yang, Jiahui Yong, Xueting Chen, Qiang Zhao, Xueli Wu, Lei Yan, Li Pang, Fan Luo, Mengjun Yu, Shanshan Pan, Deyang Li, Rouxi Chen, Juan Wang, Zhensheng Dong, Fan Yang, Yue Wang, Yang Chen, Hongjian Zheng, Zhimin Yang, Zijie Wang, Karsten Kristiansen, Hui Peng, Xiaodong Fang, Juan Shen, Yining Yang   +25 more
wiley   +1 more source

Factors associated with reporting behaviour of alcohol use in Moshi, Tanzania. [PDF]

BJPsych Open
Nickenig Vissoci JR, Nascimento de Oliveira N, Mwita WC, Pesambili M, Madundo K, Knettel BA, El-Gabri D, Mmbaga BT, Staton CA.   +8 more
europepmc   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

Editorial: Similarities and differences between substance-related and non-substance-related addictive behaviors. [PDF]

Front Psychol
Campanella S, Angioletti L, Balconi M.
europepmc   +1 more source