Results 191 to 200 of about 641,640 (263)

Transposase‐Assisted Donor Tethering Boosts Large‐Fragment HDR in Plants

Advanced Science, EarlyView.
A transposase‐assisted donor tethering strategy is developed to enhance homology‐directed repair in plants. By recruiting donor DNA to double‐strand breaks and synergizing with repair pathway reprogramming and transcription‐coupled donor design, this system markedly improves large‐fragment targeted insertion efficiency, providing a robust platform for ...
Sha Wei, Kai Zhang, Shuke Deng, Jinjie Chen, Xiaomei Huang, Jingfei Guo, Yuqing Wu, Yingjie Guo, Zhen Liang   +8 more
wiley   +1 more source

Searching for New Pharmacological Treatments of Alcohol Use Disorder (AUD): Focus on GLP-1 Receptor Agonists. [PDF]

Int J Mol Sci
Zawilska JB, Zwierzyńska E, Wojcieszak J.   +2 more
europepmc   +1 more source

A Piezo‐Mimetic Ionic Hydrogel Harnessing Joint Motion for Cartilage Repair

Advanced Science, EarlyView.
A piezo‐mimetic ionic hydrogel converts mechanical deformation into bioactive ionic currents via stress‐induced asymmetric ion migration. Coupled with sustained Mg2+ release, this mechano‐electrochemical platform bridges mechanical loading and cellular signaling, enabling load‐adaptive stimulation and enhanced cartilage regeneration. ABSTRACT Articular
Chenyuan Gao, Xinyu Wang, Zhifeng Wu, Xinya Zhang, Xiao Geng, Ti Zhang, Yue Wang, Hongwei Xia, Jun Zhang, Xianbo Qiu, Cuiru Sun, Yingjie Yu, Wenli Dai, Hua Tian, Qing Cai   +14 more
wiley   +1 more source

Does a Biochemical Approach Facilitate the Diagnosis of Prenatal Alcohol Exposure and Fetal Alcohol Spectrum Disorder in Neonatal Period? [PDF]

Int J Mol Sci
Jańczewska I, Wiergowski M, Wierzba J, Cichoń-Kotek M, Woźniak MK, Biziuk M.   +5 more
europepmc   +1 more source

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

Asymmetric Electrostrain/Electrobending in Piezoelectric Ceramics: Role of Defect Dipoles or Oxygen Vacancies

Advanced Science, EarlyView.
Defect‐configurational origins of the asymmetric apparent electrostrain are revealed in different piezoelectric ceramics via atomic‐scale visualization of defect configurations. Migration of oxygen vacancies leads to the electrobending effect in N2‐sintered BaTiO3, while defect dipoles in Ba0.99TiO2.99 generate true asymmetric electrostrain without ...
Jie Wang, Geng Huangfu, Hongjie Zhang, Tiannan Yang, Zhenhua Ma, Jingsheng Chen, Yun Liu, Yiping Guo   +7 more
wiley   +1 more source

The developmental-diagnostic gap: cultural invisibility and delayed recognition of prenatal alcohol exposure. [PDF]

Front Psychol
Kamecka M.
europepmc   +1 more source

Toward Long‐Term Reliable Human‐Machine Interaction: A Flexible, Breathable, and Self‐Powered Pressure Sensor System With Firefighting Validation

Advanced Science, EarlyView.
This work develops a breathable potentiometric self‐powered pressure sensor with good wearability, using a non‐woven fabric substrate and hydrogel electrolyte. The sensor is integrated into a five‐channel smart glove to acquire reliable hand motion signals, which are processed by a CNN for identity verification and smart vehicle control in human ...
Qilong Zhang, Zhao Yao, Jiaxu Liu, Yuxuan Hou, Zhongtao Zhang, Jingwei Xue, Leonid Chernogor, Nam Young Kim, Eun Seong Kim, Yuanyue Li, Yang Li   +10 more
wiley   +1 more source

Network structure of non-suicidal self-injury, alcohol and food addiction, and motivation in bus drivers. [PDF]

Front Psychiatry
Song X, Miao WW, Bu YY, Wang F, Zheng H, Li YF, Huang YH, Hu Q.   +7 more
europepmc   +1 more source

Lactoferrin Deficiency During Lactation Causes Adult Obesity‐Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development

Advanced Science, EarlyView.
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An, Yunxia Zou, Wenli Wang, Zhimei Cheng, Zhuoxing Zhang, Ruwei Liu, Xiong Wang, Kunlun Huang, Fangrong Ding, Yunping Dai, Qingyong Meng, Yali Zhang   +11 more
wiley   +1 more source