Results 131 to 140 of about 14,264,243 (286)

The LIVER CARE trial — screening for liver disease in individuals attending treatment for alcohol use disorder: a randomized controlled feasibility trial

Pilot and Feasibility Studies
Background Alcohol-related liver disease is a preventable disease with high mortality. If individuals with alcohol-related liver disease were to be diagnosed earlier by screening and they reduced their alcohol consumption, lives lost to alcohol-related ...
Peter Jepsen, Natasja von Wowern, Lone Galmstrup Madsen, Mette Kruse Klausen, Signe Düring, Kirstine Skov Benthien, Matilde Winther-Jensen, Janne Petersen, Gro Askgaard   +8 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Monaghan alcohol-related harm profile 2019 [PDF]

, 2019
In 2017, Monaghan was above average for mortality for all ages due to alcohol related causes (64.1 per 100,000 population, compared to a National rate of 58.6 per 100,000). In 2017, the percentage of potential years of life lost (PYLL) per 100,000 due to
Health Profile Working Group, Cullen, Louise, Goggin, Deirdre, Mason Mohan, Caroline, O'Kane, Joan, O'Donovan, Diarmuid   +5 more
core  

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Wexford alcohol-related harm profile 2019 [PDF]

, 2019
In 2017, Wexford was above average for mortality for all ages due to alcohol related causes (61.2 per 100,000 population, compared to a National rate of 58.6 per 100,000).
Health Profile Working Group, Cullen, Louise, Goggin, Deirdre, Mason Mohan, Caroline, O'Kane, Joan, O'Donovan, Diarmuid   +5 more
core  

An Overview of In Vitro Models of Alcohol‐Related Hepatocellular Carcinoma

Cancer Medicine
Background Chronic and excessive alcohol consumption is the leading cause of death due to chronic liver disease. Alcohol‐related liver disease (ALD) encompasses a broad spectrum of clinical and pathological features, ranging from asymptomatic and ...
Anoïsia Courtois, Sophie Gérard, Damien Esparteiro, Eric Nguyen‐Khac, Ingrid Marcq, Grégory Fouquet   +5 more
doaj   +1 more source

RNAi in the Rhizarian Phytopathogen Plasmodiophora brassicae: The Causal Agent of Clubroot Disease in Cruciferous Crops

Advanced Science, EarlyView.
This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Xiong Zhang, Yupo Wu, Jiachang Hou, Lixia Gao, Longqi Pan, Cuicui Shen, Chuanji Zhao, Feng Gao, Yi Zhang, Li Ren, Xiaoping Fang, Xiaoling Dun, Shengyi Liu, Lijiang Liu   +13 more
wiley   +1 more source

Associations between multiple metabolic biomarkers with steatotic liver disease subcategories: A 5-year Chinese cohort study

Cell Reports Medicine
Summary: The effectiveness of established biomarkers for non-alcoholic fatty liver disease (NAFLD) within the updated framework of steatotic liver disease (SLD) remains uncertain.
Hongli Chen, Siyu Chen, Dan Liu, Yebei Liang, Huating Li, Yuqian Bao, Zhijun Zhu, Keqing Dong, Wen Li, Liang Feng, Di Cheng, Fusong Jiang, Li Wei, Xuhong Hou, Weiping Jia   +14 more
doaj   +1 more source

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source