Results 241 to 250 of about 435,985 (290)

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source

Real world implementation of AlcoChange, a smartphone digital therapeutic to improve outcomes from alcohol-related liver disease: protocol for an individually randomised parallel group controlled trial. [PDF]

Trials
Cook A, Bamber J, Chinnery F, Webley F, Dixon E, McDonagh L, Allen R, Boddu R, Gurm H, Saffioti F, Rajoriya N, Sobell L, Sobell M, Stuart B, Kumar R, Sadique Z, Lawrence M, Ewings S, Jalan R, Mehta G.   +19 more
europepmc   +1 more source

Interface Wettability Transition‐Driven Drug Release and Dual‐Phase Functionalization in Implant Abutment

Advanced Science, EarlyView.
A temporally controlled drug release coating is developed for abutments using a superhydrophobic coating self‐assembled on mesoporous silica. This surface provides sequential functionality: initial contamination resistance through non‐wetting, followed by controlled drug release via wettability transition.
Zhongchao Wang, Liang Shi, MingXia Li, Xiao Han, Jinghan Wang, Guangping Wang, Dan Zou, Bingyang Lu, Liyuan Fan   +8 more
wiley   +1 more source

Association between serum homocysteine levels and advanced hepatic fibrosis in alcohol-related liver disease: A cross-sectional study of NHANES. [PDF]

Medicine (Baltimore)
Ma C, Zhang X, Zhang W, Duan J, Yang H.
europepmc   +1 more source

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

Advanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang, Xiuying Jiang, Xi Sun, Hao Chen, Jianjun Jin, Xin'e Shi   +5 more
wiley   +1 more source

Lipidomic analysis of alcohol use disorder patients revealed the biomarkers for alcohol-related liver disease susceptibility. [PDF]

Clin Mol Hepatol
Wang D, Zhang H, Tang Y.
europepmc   +1 more source

Intestinal Source Control of Lipid Metabolism by Enzyme‐Probiotic Encapsulated, Spatiotemporal Crosslinked, and Small Intestine‐Adhesive Hydrogel Microspheres

Advanced Science, EarlyView.
A thiol‐modified alginate hydrogel microsphere‐encapsulated enzyme‐probiotic biohybrid (AKK‐COD) system has been developed to address the spatiotemporal delivery and colonization challenges of small intestine‐targeted probiotic for lipid metabolism regulation. The system exerts sequential functions of intragastric protection, small intestinal adhesion,
Xiaolin Wu, Weiwen Liang, Siqi He, Guangyuan Chen, Hui Zhou, Xinglong Wang, Yifei Li, Dingcai Wu, Bingna Zheng, Ruoxu Dou, Rongkang Huang   +10 more
wiley   +1 more source

Pharmacological therapies for alcohol use disorder reduce hepatic decompensation & mortality in alcohol-related liver disease: A GRADE evaluation through a meta-analysis. [PDF]

Indian J Med Res
Prasad M, Varshney M, Aggarwal P.
europepmc   +1 more source

Association of life's essential 8 with mortalities in patients with alcohol-related liver disease. [PDF]

BMC Gastroenterol
Zhang X, Wu S, Cao Y, Ma S, Sun H, Liu Z.   +5 more
europepmc   +1 more source

Oxidative stress in a cellular model of alcohol-related liver disease: protection using curcumin nanoformulations. [PDF]

Sci Rep
Petagine L, Zariwala MG, Somavarapu S, Chan SHY, Kaya EA, Patel VB.   +5 more
europepmc   +1 more source