Results 51 to 60 of about 14,264,243 (286)

Alcohol’s burden of disease in Australia [PDF]

, 2014
Alcohol causes 15 deaths and hospitalises 430 Australians every day, according to this report. Summary Burden of Disease (BoD) estimates based on current health and alcohol consumption data are integral in conceptualising the impact of alcohol on the ...

core  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Mortality associated with alcohol-related liver disease [PDF]

Alimentary Pharmacology & Therapeutics, 2013
Excessive alcohol use has been reported to be responsible for 80 000 annual deaths in the United States. However, the exact cause of death related to the excessive use of alcohol has not been fully explored.To assess the effect of alcoholic liver disease (ALD) on all-cause, liver-related and cardiovascular mortality using population-based data.Data ...
G, Trimble, L, Zheng, A, Mishra, S, Kalwaney, H M, Mir, Z M, Younossi   +5 more
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Transitioning from NAFLD to MAFLD and MASLD: the toxic relationship with alcohol consumption [PDF]

Exploration of Medicine
Alcohol is a well-known toxic etiologic factor for liver injury. Metabolic substrates of alcohol (especially acetaldehyde) have a major responsibility and genetic susceptibility, alterations in microbiota and immune system are important co-factors for ...
Mubin Ozercan, Ahmed Tawheed, Mohamed El-Kassas   +2 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Diagnosis of alcohol misuse and alcoholic liver disease among patients in the medical emergency admission service of a large urban hospital in Subsaharan Africa ; a cross sectional study

The Pan African Medical Journal, 2013
INTRODUCTION: Uganda is among the top ten consumers of alcohol worldwide though there is little data on alcohol related liver disease. We describe alcohol use, alcohol misuse, and alcoholic liver disease among adults at the emergency admission service of
Christopher Kenneth Opio, Emmanuel Seremba, Ponsiano Ocama, Lalitha Rejani, Magid Kagimu, William Martens Lee   +5 more
doaj   +1 more source

Estimated projection of incidence and mortality of alcohol-related liver disease in China from 2022 to 2040: a modeling study

BMC Medicine, 2023
Background China has one of the highest numbers of liver disease cases in the world, including 6.4 million cirrhosis associated with alcohol-related liver disease (ALD) cases. However, there is still a lack of urgent awareness about the growth of alcohol
Meiyu Wu, Shuxia Qin, Chongqing Tan, Sini Li, Ouyang Xie, Xiaomin Wan   +5 more
doaj   +1 more source

Alcohol consumption and the risk of liver disease: a nationwide, population-based study

Frontiers in Medicine, 2023
IntroductionAlthough most patients with alcohol-related liver disease (ALD) have a history of prolonged and heavy drinking, there is no clear threshold defining the level of alcohol consumption that leads to ALD.
Sang Yi Moon, Minkook Son, Yeo Wool Kang, Myeongseok Koh, Jong Yoon Lee, Yang Hyun Baek   +5 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source