Results 31 to 40 of about 241,193 (244)

Comprehensive lipidomics reveals phenotypic differences in hepatic lipid turnover in ALD and NAFLD during alcohol intoxication⋆

JHEP Reports, 2021
Background & Aims: In experimental models, alcohol induces acute changes in lipid metabolism that cause hepatocyte lipoapoptosis and inflammation. Here we study human hepatic lipid turnover during controlled alcohol intoxication.
Mads Israelsen, Min Kim, Tommi Suvitaival, Bjørn Stæhr Madsen, Camilla Dalby Hansen, Nikolaj Torp, Kajetan Trost, Maja Thiele, Torben Hansen, Cristina Legido-Quigley, Aleksander Krag   +10 more
doaj   +1 more source

Gut microbiota in alcohol-related liver disease: pathophysiology and gut-brain cross talk

Frontiers in Pharmacology, 2023
Alcohol-related liver disease (ALD) from excessive alcohol intake has a unique gut microbiota profile. The disease progression-free survival in ALD patients has been associated with the degree of gut dysbiosis.
Lin Zhu, Yixuan Wang, Calvin Q. Pan, Calvin Q. Pan, Huichun Xing, Huichun Xing   +5 more
doaj   +1 more source

Epidemiology of Alcoholic Liver Disease in Korea

The Korean Journal of Gastroenterology, 2020
The harmful use of alcohol is associated with significant medical and socioeconomic burdens responsible for approximately 6% of all deaths worldwide. In Korea, the total alcohol consumption recently decreased slightly from 14.8 L of alcohol per person on
Sung Won Lee
doaj   +1 more source

Binge drinking acutely induces hepatic steatosis which is readily reversible: A real-world observational study in healthy adults

JHEP Reports
Background & Aims: Binge drinking is a common pattern of alcohol intake often considered particularly harmful. However, its immediate effects on the development of hepatic steatosis and early alcohol-related liver injury are not well established ...
Kristoffer Kjærgaard, Jeppe Mygind Yeoman, Peter Lykke Eriksen, Anne Catrine Daugaard Mikkelsen, Emilie Eifer Møller, Ann-Sophie Frees Wietz, Andressa de Zawadzki, Lars Christian Gormsen, Sara Heebøll, Hendrik Vilstrup, Karen Louise Thomsen   +10 more
doaj   +1 more source

Alcohol-induced liver injury in signalling pathways and curcumin's therapeutic potential

Toxicology Reports, 2023
Confronting the profound public health concern of alcohol-induced liver damage calls for inventive therapeutic measures. The social, economic, and clinical ramifications are extensive and demand a comprehensive understanding.
Vetriselvan Subramaniyan, Natasha Sura Anak Lubau, Nobendu Mukerjee, Vinoth Kumarasamy   +3 more
doaj   +1 more source

Are the opportunities to prevent alcohol related liver deaths in the UK in primary or secondary care? A retrospective clinical review and prospective interview study

Substance Abuse Treatment, Prevention, and Policy, 2006
Background Deaths from liver cirrhosis have increased at least 8 fold since the 1970's in the UK and further increases are anticipated, whereas in the rest of Europe liver deaths are decreasing.
Sheron Nick, Smith Stewart, Verrill Clare   +2 more
doaj   +1 more source

The impact of the COVID-19 epidemic on hospital admissions for alcohol-related liver disease and pancreatitis in Japan

Scientific Reports, 2021
During the coronavirus disease 2019 (COVID-19) pandemic, there have been health concerns related to alcohol use and misuse. We aimed to examine the population-level change in cases of alcohol-related liver disease and pancreatitis that required admission
Hisashi Itoshima, Jung-ho Shin, Daisuke Takada, Tetsuji Morishita, Susumu Kunisawa, Yuichi Imanaka   +5 more
doaj   +1 more source

Effects of Moderate Alcohol Drinking in Patients with Nonalcoholic Fatty Liver Disease

Gut and Liver, 2019
Whether moderate alcohol intake is beneficial remains an unsolved issue. Recent studies have suggested that moderate alcohol consumption is associated with beneficial effects related to the prevention of cardiovascular diseases.
Inbeom Kwon, Dae Won Jun, Jin-Hwa Moon
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source