Results 51 to 60 of about 4,677,837 (402)

Molecular Imaging of Opioid and Dopamine Systems: Insights Into the Pharmacogenetics of Opioid Use Disorders

open access: yesFrontiers in Psychiatry, 2019
Opioid use in the United States has steadily risen since the 1990s, along with staggering increases in addiction and overdose fatalities. With this surge in prescription and illicit opioid abuse, it is paramount to understand the genetic risk factors and
Jamie A. Burns   +8 more
doaj   +1 more source

Public Health Considerations and the Culture of Alcohol in Vietnam [PDF]

open access: yes, 2016
The problem of alcohol in Vietnam is interesting when considering the culture surrounding alcohol throughout the country, particularly amongst men. In 2010, Vietnamese men drank 12.1 liters of pure alcohol per capita, while women drank only 0.2 liters ...
Baquet, Daniel
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

The relationship between different dimensions of alcohol use and the burden of disease—an update

open access: yesAddiction, 2017
Background and aims Alcohol use is a major contributor to injuries, mortality and the burden of disease. This review updates knowledge on risk relations between dimensions of alcohol use and health outcomes to be used in global and national Comparative ...
J. Rehm   +11 more
semanticscholar   +1 more source

Alcohol consumption during the COVID-19 pandemic in Europe: a large-scale cross-sectional study in 21 countries (preprint)

open access: yes, 2021
Aims: The aim of this project was to investigate changes in alcohol consumption during the first months of the pandemic in Europe as well as its associations with income and experiences of distress related to the COVID-19 pandemic.
C. Kilian   +14 more
semanticscholar   +1 more source

Comparative approaches for assessing access to alcohol outlets: exploring the utility of a gravity potential approach. [PDF]

open access: yes, 2016
BackgroundA growing body of research recommends controlling alcohol availability to reduce harm. Various common approaches, however, provide dramatically different pictures of the physical availability of alcohol.
Grubesic, Tony H   +3 more
core   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

open access: yesFEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan   +2 more
wiley   +1 more source

Alcohol Use Disorder and Depressive Disorders

open access: yesAlcohol research : current reviews, 2019
Alcohol use disorder (AUD) and depressive disorders are among the most prevalent psychiatric disorders and co-occur more often than expected by chance.
R. McHugh, R. Weiss
semanticscholar   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

open access: yesFEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Advances in the science and treatment of alcohol use disorder

open access: yesScience Advances, 2019
Pharmacological and behavioral treatments exist for alcohol use disorder, but more are needed, and several are under development. Alcohol is a major contributor to global disease and a leading cause of preventable death, causing approximately 88,000 ...
K. Witkiewitz   +4 more
semanticscholar   +1 more source

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