Results 61 to 70 of about 4,580,900 (353)

Changes in alcohol use as a function of psychological distress and social support following COVID-19 related University closings

Addictive Behaviours, 2020
Highlights • Alcohol use increased significantly following COVID-19 related campus closure.• Higher social support was associated with less alcohol use overall.• Elevated psychological distress was associated with steeper increases in alcohol.• Social ...
William V. Lechner, Kimberly R. Laurene, Sweta Patel, Megan Anderson, Chelsea Grega, D. Kenne   +5 more
semanticscholar   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Pancreatic adaptive responses in alcohol abuse: Role of the unfolded protein response. [PDF]

, 2015
The majority of those who drink excessive amounts of alcohol do not develop pancreatic disease. One overarching hypothesis is that alcohol abuse requires additional risk factors, either environmental or genetic, for disease to occur.
Lugea, Aurelia, Pandol, Stephen J, Waldron, Richard T   +2 more
core   +1 more source

Comparative approaches for assessing access to alcohol outlets: exploring the utility of a gravity potential approach. [PDF]

, 2016
BackgroundA growing body of research recommends controlling alcohol availability to reduce harm. Various common approaches, however, provide dramatically different pictures of the physical availability of alcohol.
Grubesic, Tony H, Murray, Alan T, Pridemore, William Alex, Wei, Ran   +3 more
core   +1 more source

Estimation of national, regional, and global prevalence of alcohol use during pregnancy and fetal alcohol syndrome: a systematic review and meta-analysis.

Lancet Global Health, 2017
BACKGROUND Alcohol use during pregnancy is the direct cause of fetal alcohol syndrome (FAS). We aimed to estimate the prevalence of alcohol use during pregnancy and FAS in the general population and, by linking these two indicators, estimate the number ...
S. Popova, S. Lange, C. Probst, G. Gmel, J. Rehm   +4 more
semanticscholar   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Evidence Based Treatment for Excessive Alcohol Consumption and Concurrent Hypertension [PDF]

, 2020
Purpose. Excessive alcohol consumption is a preventable risk factor for hypertension, heart disease, and stroke. Though alcohol-related deaths number 88,000 annually in the U.S., alcohol use has the lowest treatment rate of behavioral health disorders at
Ward, Kimberly Ann
core   +1 more source

Olive polyphenol effects in a mouse model of chronic ethanol addiction [PDF]

, 2017
Objectives Alcohol addiction elicits oxidative imbalance and it is well known that polyphenols possess antioxidant properties. We investigated whether or not polyphenols could confer a protective potential against alcohol-induced oxidative stress ...
Bello, Cristiano, Carito, Valentina, CECCANTI, Mauro, CESTARI, VINCENZO, Coccurello, Roberto, Fiore, Marco, Mancinelli, Rosanna, Natella, Fausta   +7 more
core   +1 more source

Associations between simultaneous use of alcohol and cannabis and cannabis-related problems in 2014–2016: evidence from the Washington panel survey

Journal of Cannabis Research
Background To address the research question of how simultaneous users of alcohol and cannabis differ from concurrent users in risk of cannabis use problems after the recreational marijuana legalization in Washington State.
Yachen Zhu, Yu Ye, Thomas K. Greenfield, William C. Kerr   +3 more
doaj   +1 more source

Cannabis use frequency, route of administration, and co-use with alcohol among older adults in Washington state

Journal of Cannabis Research, 2021
Background The US national surveys and data from legal adult use cannabis states show increases in the prevalence of cannabis use among older adults, though little is known about their manner of cannabis consumption.
Meenakshi S. Subbaraman, William C. Kerr
doaj   +1 more source