Results 61 to 70 of about 1,516,378 (315)

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

FEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law, Yuan Gao, Sravya Kovvali, Pankajavalli Thirugnanasambantham, Vicki H. Wysocki, Brian M. M. Ahmer, Venkat Gopalan   +6 more
wiley   +1 more source

Imprisonment of opioid‐dependent people in New South Wales, Australia, 2000–2012: a retrospective linkage study

Australian and New Zealand Journal of Public Health, 2014
Objective: There are few data about the incarceration of opioid‐dependent people involving large representative cohorts. We aimed to determine the prevalence and duration of incarceration in a large cohort of opioid‐dependent people in Australia using ...
Louisa Degenhardt, Sarah Larney, Natasa Gisev, Judy Trevena, Lucy Burns, Jo Kimber, Marian Shanahan, Tony Butler, Richard P. Mattick, Don Weatherburn   +9 more
doaj   +1 more source

Influence of Alcohol Smell and Imagination on the Condition of the Human Organism and Subjective Human Experience [PDF]

arXiv, 2011
In this study, alcohol smell and imagination of alcohol has been shown to change the condition of a human organism.In this study, alcohol smell has been shown to change the condition of a human organism. Based on the test results, the presence of alcohol was observed upon breathing out, but was rarely observed in spits and much rarer in urines.
arxiv  

Dysfunctional tetraspanin 7 (TSP‐7) in Caenorhabditis elegans promotes; increases in average life‐ & health‐span, stress‐induced survival and motility

FEBS Open Bio, EarlyView.
The C. elegans tetraspanin‐7 (tsp‐7) is a homologue of human CD63, which is a negative regulator of autophagy. The C. elegans strain, tm5761, has a dysfunctional (knockout) tsp‐7 gene. When compared to the wild‐type strain, the tm5761 strain shows increased: life‐ and health‐span; thermotolerance, and stress‐induced locomotion.
Brogan Jones, Laurence Seabra, Francesco Michelangeli   +2 more
wiley   +1 more source

Life outcomes in adults living with FASD in a rural South African community: A follow-up study

African Journal of Disability
Background: Even though adults with foetal alcohol spectrum disorder (FASD) are at risk of negative life outcomes, there is no published evidence of this in South Africa, which has the highest estimated FASD prevalence rate globally.
Mandi Broodryk, Jaco G. Louw, Debbie Acker, Denis L. Viljoen, Leana Olivier   +4 more
doaj   +1 more source

Correct quantitative determination of ethanol and volatile compounds in alcohol products [PDF]

arXiv, 2014
Determination of the volume content of ethanol in the alcohol products in practice is usually determined by pycnometry, electronic densimetry, or densimetry using a hydrostatic balance in accordance with Commission Regulation No 2870/2000. However, these methods determine directly only density of the tested liquid sample and does not take into account ...
arxiv  

Hydrophobicity causes anomalous migration of cystine/glutamate antiporter SLC7A11 in SDS‐PAGE with low acrylamide concentration

FEBS Open Bio, EarlyView.
SLC7A11 frequently migrates faster in SDS‐PAGE. The present study found that the high hydrophobicity of SLC7A11 causes its anomalous migration in SDS‐PAGE with a low concentration of acrylamide gel. Replacing isoleucine with asparagine reduced hydrophobicity and restored its normal migration at 55 kDa, revealing the role of hydrophobicity and gel ...
Nsengiyumva Emmanuel, Qian He, Yixin Kang, Dianbao Zhang, Min Gao, Minglin Wang, Kexin Fan, Jingwen Xiong, Shaobo Wu, Botao Fa, Zhengtao Xiao, Yingfang Niu, Jun Yao, Yilei Zhang   +13 more
wiley   +1 more source

Characteristics of the Washington cannabis market from 2014 to 2016

Journal of Cannabis Research, 2022
Background The state of Washington legalized cannabis for adult use in 2012 and retail stores began to open in 2014. While details of the legal market have been tracked by the state, the total market for cannabis and characteristics of purchasers can ...
William C. Kerr, Yu Ye
doaj   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Co-nonsolvency of PNiPAM at the transition between solvation mechanisms [PDF]

Soft Matter, 2014, 10, 8288, 2014
We investigate the co-nonsolvency of poly-N-isopropyl acrylamide (PNiPAM) in different water-alcohol mixtures and show that this phenomenon is due to two distinct solvation contributions governing the phase behavior of PNiPAM in the water-rich and alcohol-rich regime respectively.
arxiv