Results 61 to 70 of about 4,677,837 (402)

Evidence Based Treatment for Excessive Alcohol Consumption and Concurrent Hypertension [PDF]

, 2020
Purpose. Excessive alcohol consumption is a preventable risk factor for hypertension, heart disease, and stroke. Though alcohol-related deaths number 88,000 annually in the U.S., alcohol use has the lowest treatment rate of behavioral health disorders at
Ward, Kimberly Ann
core   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Diagnosis and Pharmacotherapy of Alcohol Use Disorder: A Review

Journal of the American Medical Association (JAMA), 2018
Importance Alcohol consumption is associated with 88 000 US deaths annually. Although routine screening for heavy alcohol use can identify patients with alcohol use disorder (AUD) and has been recommended, only 1 in 6 US adults report ever having been ...
H. Kranzler, M. Soyka
semanticscholar   +1 more source

When wanting to change is not enough: automatic appetitive processes moderate the effects of a brief alcohol intervention in hazardous-drinking college students. [PDF]

, 2012
BACKGROUND: Research indicates that brief motivational interventions are efficacious treatments for hazardous drinking. Little is known, however, about the psychological processes that may moderate intervention success.
Ostafin, Brian D., Palfai, Tibor P.
core   +2 more sources

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Cannabis use frequency, route of administration, and co-use with alcohol among older adults in Washington state

Journal of Cannabis Research, 2021
Background The US national surveys and data from legal adult use cannabis states show increases in the prevalence of cannabis use among older adults, though little is known about their manner of cannabis consumption.
Meenakshi S. Subbaraman, William C. Kerr
doaj   +1 more source

Alcoholic and non-alcoholic steatohepatitis [PDF]

Experimental and Molecular Pathology, 2014
This paper is based upon the “Charles Lieber Satellite Symposia” organized by Manuela G. Neuman at the Research Society on Alcoholism (RSA) Annual Meetings, 2013 and 2014. The present review includes pre-clinical, translational and clinical research that characterize alcoholic liver disease (ALD) and non-alcoholic steatohepatitis (NASH). In addition, a
Samuel W. French, Brittany Tillman, Iain H. McKillop, Murali Ganesan, Abraham Bautista, Hui Liu, Hong Shen, Devanshi Seth, Paul G. Thomes, Irina A. Kirpich, Steve Malnick, Craig J. McClain, Kusum K. Kharbanda, Radu M. Nanau, Barbara A. French, Jun Li, Mihai Opris, Manuela G. Neuman, Lawrence Cohen, Mihai Voiculescu, Helmut K. Seitz, Sebastian Mueller, Natalia A. Osna, Kyle J. Thompson, Ramon Bataller   +24 more
openaire   +3 more sources

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

PLoS ONE, 2018
Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown.
M. Feitosa, A. Kraja, D. Chasman, Y. Sung, T. Winkler, I. Ntalla, Xiuqing Guo, N. Franceschini, Ching-Yu Cheng, X. Sim, D. Vojinovic, J. Marten, S. Musani, Changwei Li, A. Bentley, Michael R. Brown, K. Schwander, Melissa A. Richard, R. Noordam, H. Aschard, Traci M. Bartz, L. Bielak, R. Dorajoo, Virginia Fisher, F. Hartwig, A. Horimoto, K. Lohman, A. Manning, T. Rankinen, A. Smith, S. Tajuddin, M. Wojczynski, Maris Alver, M. Boissel, Q. Cai, A. Campbell, Jin-Fang Chai, Xu Chen, J. Divers, Chuan Gao, A. Goel, Y. Hagemeijer, S. Harris, M. He, F. Hsu, A. Jackson, M. Kähönen, A. Kasturiratne, P. Komulainen, Brigitte Kühnel, F. Laguzzi, J. Luan, N. Matoba, I. Nolte, S. Padmanabhan, Muhammad B. Riaz, R. Rueedi, A. Robino, M. A. Said, R. Scott, T. Sofer, A. Stančáková, F. Takeuchi, B. Tayo, Peter J. van der Most, T. Varga, V. Vitart, Yajuan Wang, E. Ware, H. Warren, S. Weiss, W. Wen, L. Yanek, Weihua Zhang, Jinghua Zhao, S. Afaq, N. Amin, M. Amini, D. Arking, T. Aung, E. Boerwinkle, I. Borecki, U. Broeckel, Morris J. Brown, M. Brumat, G. Burke, M. Canouil, A. Chakravarti, S. Charumathi, Y. Ida Chen, J. Connell, A. Correa, L. de las Fuentes, R. de Mutsert, H. J. de Silva, Xuan Deng, Jingzhong Ding, Qing Duan, C. Eaton, G. Ehret, R. N. Eppinga, E. Evangelou, J. Faul, S. Felix, N. Forouhi, T. Forrester, O. Franco, Y. Friedlander, I. Gandin, He Gao, M. Ghanbari, B. Gigante, C. Gu, D. Gu, S. Hagenaars, G. Hallmans, T. Harris, Jiang He, S. Heikkinen, C. Heng, M. Hirata, B. Howard, M. Ikram, U. John, T. Katsuya, C. Khor, T. Kilpeläinen, W. Koh, J. Krieger, S. Kritchevsky, M. Kubo, J. Kuusisto, T. Lakka, C. Langefeld, C. Langenberg, L. Launer, B. Lehne, C. Lewis, Yize Li, Shiow J. Lin, Jianjun Liu, Jingmin Liu, M. Loh, T. Louie, R. Mägi, C. McKenzie, T. Meitinger, A. Metspalu, Y. Milaneschi, L. Milani, K. Mohlke, Y. Momozawa, M. Nalls, C. Nelson, N. Sotoodehnia, J. Norris, Jeffery R O'connell, Nicholette D. Palmer, T. Perls, N. Pedersen, A. Peters, P. Peyser, N. Poulter, L. Raffel, O. Raitakari, Kathryn Roll, L. Rose, F. Rosendaal, J. Rotter, C. Schmidt, P. Schreiner, N. Schupf, W. Scott, P. Sever, Yuan Shi, S. Sidney, M. Sims, C. Sitlani, Jennifer A. Smith, H. Snieder, J. Starr, K. Strauch, H. Stringham, N. Tan, Hua Tang, K. Taylor, Y. Teo, Y. Tham, S. Turner, A. Uitterlinden, P. Vollenweider, M. Waldenberger, Lihua Wang, Y. X. Wang, W. Wei, Christine A. Williams, Jie Yao, Caizheng Yu, Jian-Min Yuan, Wei Zhao, A. Zonderman, D. Becker, M. Boehnke, D. Bowden, J. Chambers, I. Deary, T. Esko, M. Farrall, P. Franks, B. Freedman, P. Froguel, P. Gasparini, C. Gieger, J. Jonas, Y. Kamatani, N. Kato, J. Kooner, Z. Kutalik, M. Laakso, C. Laurie, K. Leander, T. Lehtimäki, Lifelines Cohort Study, P. Magnusson, A. Oldehinkel, B. Penninx, O. Polašek, D. Porteous, R. Rauramaa, N. Samani, J. Scott, X. Shu, P. van der Harst, L. Wagenknecht, N. Wareham, H. Watkins, D. Weir, A. R. Wickremasinghe, Tangchun Wu, W. Zheng, C. Bouchard, K. Christensen, M. Evans, V. Gudnason, B. Horta, S. Kardia, Yongmei Liu, A. Pereira, B. Psaty, P. Ridker, R. V. van Dam, W. Gauderman, Xiaofeng Zhu, D. Mook-Kanamori, M. Fornage, C. Rotimi, L. Cupples, T. Kelly, E. Fox, C. Hayward, C. V. van Duijn, E. Tai, T. Wong, C. Kooperberg, W. Palmas, K. Rice, A. Morrison, P. Elliott, M. Caulfield, P. Munroe, D. Rao, M. Province, D. Levy   +272 more
semanticscholar   +1 more source

Alcohol affects neuronal substrates of response inhibition but not of perceptual processing of stimuli signalling a stop response [PDF]

, 2013
Alcohol impairs inhibitory control, including the ability to terminate an initiated action. While there is increasing knowledge about neural mechanisms involved in response inhibition, the level at which alcohol impairs such mechanisms remains poorly ...
A Green, A Hampshire, A Mehrabian, A Nambu, A Rey, AD Chevrier, AJ Caswell, AL Norman, AR Aron, AR Aron, AR Aron, AR Aron, AR Aron, BM Anderson, C Easdon, CA Marczinski, CA Marczinski, CA Marczinski, CD Chambers, CM Dodds, CM Steele, CN Boehler, CN Boehler, CN White, CR Guillot, CS Li, DJ Sharp, DM Dougherty, DM McCarthy, DM Torta, F Esposito, F Verbruggen, F Verbruggen, GD Logan, GE Alexander, GE Alexander, H de Wit, HM Duvernoy, Hugo Critchley, J Ashburner, J Chikazoe, J Weafer, JH Patton, JL Kenemans, JM Townshend, K Fromme, K Katanoda, K Marinkovic, K Nikolaou, K Rubia, KJ Friston, Kyriaki Nikolaou, L Boucher, LE Mulvihill, M Field, M Sano, MA Schuckit, Marcus Gray, MC Stevens, MT Fillmore, MT Fillmore, N Weiskopf, ND Volkow, NH Naqvi, R Deichmann, R Weissenborn, RB Buxton, RN Henson, RS Ross, RZ Goldstein, S Loeber, S Loeber, S Loeber, SC Matthews, SD Slotnick, T Duka, T Nichols, T Singer, Theodora Duka   +78 more
core   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source