Results 111 to 120 of about 1,338,228 (382)
Advanced Science, EarlyView.Glycolysis‐derived lactate activates nucleus pulposus cell ferroptosis via Histon H3K18la‐mediated ACSL4 transcription and ACSL4 lactylation and aggravate intervertebral disc degeneration. Inhibiting glycolysis via gene silencing or chemical intervention reduces the production of lactate and ameliorates ferroptosis activation and nucleus pulposus ...
Kaiqiang Sun +10 more
wiley +1 more source
Journal of Lipid Research, 1961 Allyl pyrophosphates (3,3-dimethylallyl, geranyl, and farnesyl pyrophosphate), which are known intermediates in the biosynthesis of squalene from mevalonate, are also metabolized in the liver by an alternative pathway to acids.
J. Christophe, G. Popják
doaj
Turmeric extract (Curcuma longa L.) regulates hepatic toxicity in a single ethanol binge rat model
Heliyon, 2022 Hepatic alcohol clearance is a key factor to overcome alcohol hangovers, and over the period, alcohol hangovers may lead to inflammation and oxidative stress.
Hwa-Young Lee +8 more
doaj
Metabolism of ethyl alcohol and the development of cancer
Alcoholism and Drug Addiction, 2018 The main metabolic pathway of ethanol elimination occurs in the liver. Ethanol is oxidised by an alcohol dehydrogenase (ADH) to a very toxic acetaldehyde. The aldehyde is converted to acetate by an aldehyde dehydrogenase (ALDH).
Wanda Dyr
doaj +1 more source
Applied Microbiology and Biotechnology, 2009 Biofuels synthesized from renewable resources are of increasing interest because of global energy and environmental problems. We have previously demonstrated production of higher alcohols from Escherichia coli using a 2-keto acid-based pathway.
S. Atsumi +5 more
semanticscholar +1 more source
Biochemical genetic polymorphism in Indian mackerel (Rastrelliger kanagurta) [PDF]
, 2000 Six enzymes glucose 6 phosphate dehydrogenase (G6PD), xanthene de hydrogenase (XDH), alcohol dehydrogenase (ADH), peroxidase (PO), lactate dehydrogenase (LDH) and isocitric dehydrogenase (lDH) were examined to discover the genetic variation in Indian ...
George, M K +3 more
core
Characterization of the human omega-oxidation pathway for omega-hydroxy-very-long-chain fatty acids [PDF]
, 2008 Very-long-chain fatty acids (VLCFAs) have long been known to be degraded exclusively in peroxisomes via beta-oxidation. A defect in peroxisomal beta-oxidation results in elevated levels of VLCFAs and is associated with the most frequent inherited ...
Dacremont, Georges +4 more
core +2 more sources
Engineered Hydrogels for Organoid Models of Human Nonalcoholic Fatty Liver Disease
Advanced Science, EarlyView.Nonalcoholic fatty liver disease (NAFLD) is characterized by lipid accumulation and extracellular matrix stiffening. An in vitro NAFLD model is developed using engineered hydrogels (G′ ≈ 1–6 kPa) and iPSC‐derived hepatic organoids. It is demonstrated that higher stiffness can increase lipid droplet accumulation, fibrosis, and metabolic dysregulation ...
Yueming Liu +11 more
wiley +1 more source
Nutrition and Dietary SupplementsMichael B La Monica, Betsy Raub, Shelley Hartshorn, Ashley Gustat, Jodi Grdic, Jennifer Sandrock The Center for Applied Health Sciences, Canfield, OH, USACorrespondence: Michael B La Monica, The Center for Applied Health Sciences, 6570 Seville Dr ...
La Monica MB +5 more
doaj
Journal of Functional Foods, 2023 Excessive alcohol intake leads to alcoholic liver injury via hepatic acetaldehyde accumulation. Some probiotic bacteria, such as Lactiplantibacillus plantarum and Bifidobacterium, are known to have the ability to break down acetaldehyde; however, there ...
Jong-Hwa Kim +5 more
doaj