Results 141 to 150 of about 1,349,906 (378)

Activation of Spinal Astrocyte α2A Adrenoceptors Protects Against Sepsis‐Induced Heart Injury Through Inhibition of GABAergic Neuronal Necroptosis

Advanced Science, EarlyView.
The study in this paper found that activating the α2A receptors of astrocytes in the thoracic spinal cord can reduce the release of inflammatory factors, thereby decreasing the necroptosis of GABAergic neurons and consequently alleviating myocardial injury caused by sepsis.
Ruilin He, Bin Wu, Liuhu Han, Mingde Li, Wenli Guo, Jiajing Fu, Bin Mei, Eric R. Gross, Xuesheng Liu, Yao Lu   +9 more
wiley   +1 more source

Ternary Complex Formation of Fatty Acids and Fatty Acid Amides with Horse Liver Alcohol Dehydrogenase-Coenzyme Complexes. [PDF]

, 1959
Alfred D. Winer, Hugo Theorell, Maie Ojamäe, Björn Högberg, P. Kneip, H. Palmstierna   +5 more
openalex   +1 more source

Targeting Hyperglycemic Bone Pre‐Metastatic Niche for Breast Cancer Bone Metastasis Therapy

Advanced Science, EarlyView.
This study reveals that breast cancer creates a hyperglycemic pre‐metastatic niche in bone prior to colonization and amplifies glucose metabolism post‐metastasis. To target this mechanism, a biomimetic enzyme‐engineered nanoplatform that disrupts tumor glycolytic pathways, proposing a therapeutic strategy to inhibit breast cancer bone metastasis by ...
Jianxin Ye, Peng Hu, Rui Zhang, Lei Zhou, Zonghua Luo, Yanan Chen, Shengzhe Ruan, Mengyi Zhu, Huaze Ding, Yike Qian, Yan Xing, Tong Meng, Changping Wang, Dianwen Song   +13 more
wiley   +1 more source

Distribution of enzymes cleaving pyridine nucleotides in animal tissues [PDF]

, 1957
A number of enzymes capable of splitting the pyridine nucleotides have been found in animal tissues. A portion of the DPNase (1) that hydrolyzes the nicotinamide ribose bond of DPN and TPN was reported in the microsomes of rat liver (1).
Jacobson, K. Bruce, Kaplan, Nathan O.
core   +1 more source

Additive Manufactured Magnetoelectric Wireless Retainer as the Periodontal Remodeler for Post‐Orthodontic Tissue Reconstruction and Relapse‐Inhibition

Advanced Science, EarlyView.
Orthodontic relapse persists as a 120‐year challenge, as traditional retainers fail to remodel tissue, causing lifelong dependence. This study demonstrates a flexible magnetoelectric retainer (FMOR) enabling wireless periodontal remodeling. FMOR cues shift periodontal ligament cell (PDLC) paracrine signaling, promoting M2 macrophages, osteogenic ...
Haoqi Lei, Jiwei Sun, Peng Chen, Li Hu, Xin Zhou, Shiqiang Gong, Qingming Tang, Xiaoqing Han, Lili Chen, Bin Su   +9 more
wiley   +1 more source

Regioselective C─H Functionalization by the Combination of Enzymatic and Chemocatalytic Reactions in Water

Angewandte Chemie, EarlyView.
H3CP contributes to sustainable synthesis by integrating regioselective enzymatic halogenation, Pd‐catalyzed Heck coupling, and enzymatic hydrolysis. TPGS‐705‐M micelles enable the Pd‐catalyzed step, allowing seamless compatibility with enzymatic reactions in one vessel under aqueous conditions.
Ran Zhu, Xuhua Mo, Tanja Gulder, Tobias A. M. Gulder   +3 more
wiley   +2 more sources

A data catalogue of alcohol dehydrogenases in the genome of a tissue macerating Pectobacterium brasiliense isolated from potato in South Africa

Data in Brief
Alcohol dehydrogenases (ADHs) catalyze the oxidation of alcohols and reduction of aldehydes and ketones. Primarily ADHs mitigate aldehydes and alcohol toxicity but they may also perform other functions. we listed all ADHs in the genome of strain BD163 of
Sarah Oluwatobi Otun, Khayalethu Ntushelo   +1 more
doaj  

Dissociation Constants of Ternary Complexes of Fatty Acids and Fatty Acid Amides with Horse Liver Alcohol Dehydrogenase-Coenzyme Complexes. [PDF]

, 1960
Alfred D. Winer, Hugo Theorell, Robert G. Heath, E. Varde, Gertrud Westin   +4 more
openalex   +1 more source

Engineering Adenine Deaminase TadA for Precise and PAM‐Flexible Point Mutagenesis and Gradient‐Tuning Endogenous Protein Design

Advanced Science, EarlyView.
Base editing enables precise nucleotide substitutions but limited by bystander editing. This study engineers plant base editors by fusing optimized TadA variants with PAM‐flexible SpRY nickase, enabling A‐to‐G, C‐to‐T, and dual‐base conversions in a highly condensed window (≤3 nucleotides). Additionally, TadDBE (TadA Dual‐Base Editor)‐mediated directed
Kangli Sun, Si Cheng, Nan Chai, Jianing Mi, Ruixiang Zhang, Qian Qian, Zhiye Zheng, Ke Chen, Dongchang Zeng, Xin Peng, Mengyuan Shen, Degui Zhou, Qinlong Zhu, Qi Liu, Jiantao Tan   +14 more
wiley   +1 more source

The Natural Redox Cofactor Pyrroloquinoline Quinone (PQQ) Enables Photocatalytic Radical Cyclizations

Angewandte Chemie, EarlyView.
Natural alcohol and sugar dehydrogenases that utilize the redox cofactor pyrroloquinoline quinone (PQQ) can be repurposed for enantioselective photoredox catalysis. Upon blue‐light irradiation, redox‐neutral radical cyclizations are catalyzed. This work adds a new class of enzymes to the toolbox of photobiocatalysis.
Srishti B. Bahukhandi, Andreas S. Klein, Ghulam Mustafa, Maria Weyh, Alexandra Walter, Erling Thyrhaug, Jürgen Hauer, Golo Storch, Cathleen Zeymer   +8 more
wiley   +2 more sources