Results 161 to 170 of about 912,546 (293)

Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry

Chemistry – A European Journal, EarlyView.
Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi, Alessandro Rubbi, Pablo A. Nogara, Giovanni Ribaudo, Vito Lippolis, João B. T. Rocha, Laura Orian   +6 more
wiley   +1 more source

Two distinct alcohol dehydrogenase classes mediate bacterial 2-hydroxyethylphosphonate catabolism. [PDF]

Protein Sci
Piazza F, Rodella M, Salanti N, Merici G, Rossi E, Rivetti C, Götzinger F, Pallitsch K, Peracchi A.   +8 more
europepmc   +1 more source

Modular Assembly of a Biocatalytic Material for Stereoselective C─Si Bond Formation

Chemistry – A European Journal, EarlyView.
A modular, carrier‐free enzyme foam derived from Rhodothermus marinus cytochrome c combines structural stability with catalytic efficiency for stereoselective C─Si bond formation. Streptavidin (STV)‐mediated protein crosslinking creates a robust, self‐supporting materials platform for next‐generation biocatalysis.
Marc F. Münker, Annika J. Weber, Madleen Richter, Jennifer Kühne, Carmen M. Dominguez, Christof M. Niemeyer, Kersten S. Rabe   +6 more
wiley   +1 more source

Toward Cost-Effective and Sustainable Production of 2,5-Bis(hydroxymethyl)furan by an Engineered Alcohol Dehydrogenase EcYjgB. [PDF]

ChemSusChem
Wei JY, Wang JP, Li N.
europepmc   +1 more source

Patients with Chronic Inflammatory Diseases Can Experience Higher Exposure of Small Molecule Drugs than Healthy Volunteers: An Analysis of Recently Approved Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Chronic inflammation has long been known to downregulate the activity of certain cytochrome P450 (CYP) enzymes—the main enzymes responsible for the phase I metabolism of many small molecule drugs—potentially leading to higher exposures in patients with chronic inflammatory diseases compared to healthy volunteers. Neglecting this potential difference in
Johannes Tillil, Sathej Gopalakrishnan, Jennifer Dong, Karthik Venkatakrishnan, Charlotte Kloft, Wilhelm Huisinga, Lena Klopp‐Schulze   +6 more
wiley   +1 more source

Redox Biocatalysis in Lidocaine‐Based Hydrophobic Deep Eutectic Solvents: Non‐Conventional Media Outperform Aqueous Conditions

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
Two hydrophobic DESs, lidocaine/oleic acid and lidocaine/decanoic acid, were utilized as reaction media that were enzyme‐compatible and highly substrate‐solubilizer for carbonyl reduction catalyzed by horse liver alcohol dehydrogenase, focusing on the effect of water contents and on maximizing substrate loadings, which showcases for the first time the ...
Ningning Zhang, Viktoria Lahmann, Jan Philipp Bittner, Pablo Domínguez de María, Sven Jakobtorweihen, Irina Smirnova, Selin Kara   +6 more
wiley   +1 more source

Comprehensive Bioinformatic Analysis and Expression Profiling of the Alcohol Dehydrogenase (<i>ADH</i>) Gene Family in <i>Morus alba</i>. [PDF]

Biology (Basel)
Tang J, Xie M, Zhou M, Zhang S, Li Y, Hu J.   +5 more
europepmc   +1 more source

A proteomic investigation of forebrain regeneration in the leopard gecko (Eublepharis macularius)

Developmental Dynamics, EarlyView.
Our investigation reveals ontogenetic, injury‐ and regeneration‐associated proteomic changes in the leopard gecko forebrain. Abstract Background The ability to replace lost or damaged neurons following an injury is termed reactive neurogenesis. Although reactive neurogenesis has been reported in several lizard species, the molecular mechanisms ...
Alexandra I. Noble, Samantha L. Payne, Matthew K. Vickaryous   +2 more
wiley   +1 more source

YEAST ALCOHOL DEHYDROGENASE

Journal of Biological Chemistry, 1957
Jan Van Eys, Margaret M. Ciotti, Nathan O. Kaplan   +2 more
openaire   +1 more source

Serum methylmalonic acid levels and epilepsy prevalence: Association analysis, exploratory mediation, and clinical corroboration

Epileptic Disorders, EarlyView.
Abstract Objective This study aimed to investigate the association between methylmalonic acid (MMA) and epilepsy prevalence and to explore potential inflammatory and nutritional pathways underlying this association. Methods This study included adults aged ≥ 20 years from the National Health and Nutrition Examination Survey (NHANES) 2011–2014.
Ningyu Wei, Ning Huang, Haipeng Chen, Rui Tang, Yuan Cheng, Xiang Zhang   +5 more
wiley   +1 more source