Results 281 to 290 of about 1,538,079 (344)
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Science, 1968
Significant alcohol dehydrogenase activity has been demonstrated in the soluble fraction of rat brain and is very similar to the liver enzyme in kinetic properties and responses to inhibitors. A cerebral mechanism that oxidizes ethanol may play a significant role in local adjustments during exposure to ethanol and in the pathogenesis of the neural ...
N H, Raskin, L, Sokoloff
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Significant alcohol dehydrogenase activity has been demonstrated in the soluble fraction of rat brain and is very similar to the liver enzyme in kinetic properties and responses to inhibitors. A cerebral mechanism that oxidizes ethanol may play a significant role in local adjustments during exposure to ethanol and in the pathogenesis of the neural ...
N H, Raskin, L, Sokoloff
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Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster
Nature, 1983M. Kreitman
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Chemico-Biological Interactions, 2017
Close to 80 years of research have brought MDR alcohol dehydrogenases (ADHs) from unknown molecular concepts to molecules known in exact detail regarding structural, functional and evolutionary properties. They can be traced backwards in at least six stages of development, to essentially the origin of cellular life, and have been monitored in a long ...
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Close to 80 years of research have brought MDR alcohol dehydrogenases (ADHs) from unknown molecular concepts to molecules known in exact detail regarding structural, functional and evolutionary properties. They can be traced backwards in at least six stages of development, to essentially the origin of cellular life, and have been monitored in a long ...
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An alcohol dehydrogenase ribozyme
Nature Structural & Molecular Biology, 2003We report an RNA molecule that exhibits activity analogous to that of alcohol dehydrogenase (ADH). Directed in vitro evolution was used to enrich nicotinamide adenine dinucleotide (NAD+)-dependent redox-active RNAs from a combinatorial pool. The most active ribozyme in the population forms a compact pseudoknotted structure and oxidizes an alcohol seven
Shinya, Tsukiji +2 more
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Alcohol and polyol dehydrogenases
Pharmacology Biochemistry and Behavior, 1983"Long" and "short" alcohol dehydrogenases with different structures and catalytic mechanisms exist and the same sub-grouping appears to apply to polyol dehydrogenases. Mammalian liver sorbitol dehydrogenase is clearly related to "long" alcohol dehydrogenases and has structural properties intermediate between those of mammalian and yeast alcohol ...
H, Jörnvall, M, Carlquist, J, Jeffery
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ALCOHOL AND ALDEHYDE DEHYDROGENASE*
Alcohol and Alcoholism, 1990The enzymes mainly responsible for ethanol degradation in humans are liver alcohol dehydrogenases (ADH) and aldehyde dehydrogenases (ALDH). Polymorphisms occur in both enzymes, with marked differences in the steady-state kinetic constants. The Km-values for ethanol of ADH isoenzymes relevant for alcohol degradation range from 49 microM to 36 microM ...
T, Ehrig, W F, Bosron, T K, Li
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Acetylcarnitine Inhibits Alcohol Dehydrogenase
Biochemical and Biophysical Research Communications, 1994Carnitine and acetylcarnitine are used as dietary supplements and as therapeutic agents. Carnitine attenuates ethanol metabolism in intact animals but the in vitro activities of alcohol dehydrogenase (ADH), microsomal ethanol oxidizing system (MEOS) or catalase are not significantly altered by carnitine.
D S, Sachan, Y S, Cha
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Yeast alcohol dehydrogenase II
Archives of Biochemistry and Biophysics, 1957Abstract Many lines of evidence support the existence of a new alcohol dehydrogenase in yeast. The new enzyme showed a broad spectrum of activity with various alcohols, ethanol having the highest activity. Its properties in many respects appear to be different from the classical alcohol dehydrogenase, and the new enzyme is more able to oxidize the ...
K, EBISUZAKI, E S, GUZMAN BARRON
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The role of aldehyde dehydrogenase 2 in cardiovascular disease
Nature Reviews Cardiology, 2023Jian Zhang +11 more
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The Alcohol Dehydrogenase System
1995Alcohol dehydrogenases of different types are common enzymes in nature. Two of these families, the medium-chain dehydrogenase/reductase family, MDR, and the shortchain dehydrogenase/reductase family, SDR, are well studied and known since long, but have experienced a recent “explosion” of new knowledge, extension and importance.
H, Jörnvall +4 more
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