Results 51 to 60 of about 1,338,228 (382)

Class IV mammalian alcohol dehydrogenase Structural data of the rat stomach enzyme reveal a new class well separated from those already characterized [PDF]

The stomach form of alcohol dehydrogenase has been structurally evaluated by peptide analysis covering six separate regions of the rat enzyme. Overall, this new structure diners widely (32–40% residue differences) from the structures of three classes of ...
Cederlund, Ella, Höög, Jan-Olov, Jörnvall, Jans, Moreno, Alberto, Parés, Xavier   +4 more
core   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

In vivo Hypoxia and a Fungal Alcohol Dehydrogenase Influence the Pathogenesis of Invasive Pulmonary Aspergillosis

PLoS Pathogens, 2011
Currently, our knowledge of how pathogenic fungi grow in mammalian host environments is limited. Using a chemotherapeutic murine model of invasive pulmonary aspergillosis (IPA) and 1H-NMR metabolomics, we detected ethanol in the lungs of mice infected ...
Nora Grahl, S. Puttikamonkul, J. Macdonald, M. P. Gamcsik, Lisa Y. Ngo, T. Hohl, R. Cramer   +6 more
semanticscholar   +1 more source

Genetic Variation in HSD17B13 Reduces the Risk of Developing Cirrhosis and Hepatocellular Carcinoma in Alcohol Misusers

Hepatology, 2020
Carriage of rs738409:G in patatin‐like phospholipase domain containing 3 (PNPLA3) is associated with an increased risk for developing alcohol‐related cirrhosis and hepatocellular carcinoma (HCC).
F. Stickel, P. Lutz, S. Buch, H. Nischalke, I. Silva, V. Rausch, J. Fischer, K. Weiss, D. Gotthardt, J. Rosendahl, A. Marot, Mona Elamly, M. Krawczyk, M. Casper, F. Lammert, Thomas Buckley, A. McQuillin, U. Spengler, F. Eyer, A. Vogel, S. Marhenke, J. von Felden, H. Wege, Rohini Sharma, S. Atkinson, A. Franke, S. Nehring, V. Moser, C. Schafmayer, L. Spahr, C. Lackner, R. Stauber, A. Canbay, A. Link, Luca Valenti, J. Grove, G. Aithal, J. Marquardt, W. Fateen, S. Zopf, J. Dufour, J. Trebicka, C. Datz, P. Deltenre, S. Mueller, T. Berg, J. Hampe, M. Morgan   +47 more
semanticscholar   +1 more source

Functional characterization of SlscADH1, a fruit-ripening associated short-chain alcohol dehydrogenase of tomato [PDF]

, 2012
A tomato short-chain dehydrogenase-reductase (SlscADH1) is preferentially expressed in fruit with a maximum expression at the breaker stage while expression in roots, stems, leaves and flowers is very weak.
Abel, Alain Latché, Baldwin, Bate, Benoît van der Rest, Birtic, Bombarely, Campos, Cheng, Christian Chervin, Christian Ginies, Croteau, Damiani, Defilippi, DeLong, Emmanuel Youmbi, Finn, Fisher, Goffner, Gonzalez-Aguero, González-Guzmán, Hall, Hanane Moummou, Hellens, Jean-Claude Pech, Jones, Kallberg, Kim, Koeduka, Leclercq, Libert Brice Tonfack, Longhurst, Malcomber, Manriquez, Marti, Mohamed Benichou, Pech, Polizzi, Prestage, Ringer, Scherbak, Shimura, Singh, Speirs, Sponsel, Strommer, Tamura, Tesniere, Tieman, Tonfack, Torregrosa, Van Haaren, Wu, Xia, Zhang   +54 more
core   +3 more sources

H2O2‐Generating Advanced Nanomaterials for Cancer Treatment

Advanced Functional Materials, EarlyView.
H2O2‐generating nanoplatforms can exploit tumor redox imbalance for O2 and toxic reactive oxygen species generation, leading to hypoxia reversal, and apoptosis of cancer cells, respectively. This review highlights the mechanisms of these nanoplatforms, including exogenous H₂O₂ delivery, endogenous amplification, and metal peroxides, which leads to ...
Kiyan Musaie, Samin Abbaszadeh, Kik Marais, Vahideh Nosrati‐Siahmazgi, Saman Rezaei, Bo Xiao, Kamal Dua, Hélder A. Santos, Mohammad‐Ali Shahbazi   +8 more
wiley   +1 more source

An iron‐activated alcohol dehydrogenase [PDF]

FEBS Letters, 1983
An alcohol dehydrogenase isolated from Zymomonas mobilis was found to be activated by ferrous ions but not by zinc, after inactivation with metal‐complexing agents. Cobaltous ions also re‐activated to a lesser extent. It is suggested that in this species the alcohol dehydrogenase naturally contains iron.
openaire   +3 more sources

Longevity-associated NADH Dehydrogenase Subunit-2 237 Leu/Met Polymorphism Modulates the Effects of Daily Alcohol Drinking on Yearly Changes in Serum Total and LDL Cholesterol in Japanese Men [PDF]

, 2009
Reduced nicotinamide adenine dinucleotide (NADH) dehydrogenase subunit 2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism, is reportedly associated with longevity in the Japanese population.
Hayashi, Junichi, Ishikawa, Mamoru, Karita, Kanae, Kitamoto, Kiyoshi, Kokaze, Akatsuki, Makita, Ryuji, Matsunaga, Naomi, Ohtsu, Tadahiro, Takashima, Yutaka, Tanaka, Nobukazu, Yamamoto, Minoru, Yoshida, Masao   +11 more
core   +1 more source

Novel Less Toxic, Lymphoid Tissue‐Targeted Lipid Nanoparticles Containing a Vitamin B5‐Derived Ionizable Lipid for mRNA Vaccine Delivery

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
The top‐performing lipid nanoparticle, incorporating a novel ionizable lipid derived from vitamin B5, demonstrates high mRNA transfection efficiency, low toxicity, favorable stability, targeted delivery to lymphoid tissues, and high immunogenicity, showing promise as a carrier for mRNA vaccines for infectious diseases and cancer.
Soyeon Yoo, Muhammad Faisal, Seo‐Hyeon Bae, Kounghwa Youn, Hyo‐Jung Park, Sung Pil Kwon, Il Kwon Hwang, Jisun Lee, Hyeong Jun Kim, Jae‐Hwan Nam, Gyochang Keum, Eun‐Kyoung Bang   +11 more
wiley   +1 more source

Origin of the enantioselectivity of alcohol dehydrogenase

Physical Chemistry Chemical Physics, 2023
Deciphering the enantioselectivity of Alcohol dehydrogenases (ADH) that catalyse the interconversion between ketones/aldehydes and alcohols in the presence of NADPH cofactor.
Jiahui Zhou, Tao Han, Shahbaz Ahmad, Derek Quinn, Thomas S. Moody, Qi Wu, Meilan Huang   +6 more
openaire   +4 more sources