Results 61 to 70 of about 1,349,906 (378)

Genetic Variation in HSD17B13 Reduces the Risk of Developing Cirrhosis and Hepatocellular Carcinoma in Alcohol Misusers

open access: yesHepatology, 2020
Carriage of rs738409:G in patatin‐like phospholipase domain containing 3 (PNPLA3) is associated with an increased risk for developing alcohol‐related cirrhosis and hepatocellular carcinoma (HCC).
F. Stickel   +47 more
semanticscholar   +1 more source

An iron‐activated alcohol dehydrogenase [PDF]

open access: yesFEBS Letters, 1983
An alcohol dehydrogenase isolated from Zymomonas mobilis was found to be activated by ferrous ions but not by zinc, after inactivation with metal‐complexing agents. Cobaltous ions also re‐activated to a lesser extent. It is suggested that in this species the alcohol dehydrogenase naturally contains iron.
openaire   +3 more sources

Novel Less Toxic, Lymphoid Tissue‐Targeted Lipid Nanoparticles Containing a Vitamin B5‐Derived Ionizable Lipid for mRNA Vaccine Delivery

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
The top‐performing lipid nanoparticle, incorporating a novel ionizable lipid derived from vitamin B5, demonstrates high mRNA transfection efficiency, low toxicity, favorable stability, targeted delivery to lymphoid tissues, and high immunogenicity, showing promise as a carrier for mRNA vaccines for infectious diseases and cancer.
Soyeon Yoo   +11 more
wiley   +1 more source

Preparation of corn glycopeptides and evaluation of their antagonistic effects on alcohol-induced liver injury in rats

open access: yesJournal of Functional Foods, 2020
New glycosylated zein peptides (GZP) were produced by transglutaminase-induced d-glucosamine conjugation onto zein peptides. GZP’s antagonistic effects on alcohol-induced liver injury in rats were evaluated.
Xiao-jie Wang   +4 more
doaj  

The Metabolism of Alcohol: Risk and Protective Factors [PDF]

open access: yes, 2015
Purpose: Abstract for poster submission to VCU Poster Symposium for Undergraduate Research and Creativity Title: The Metabolism of Alcohol: Risk and Protective Factors Background: In 2002, it was reported by the National Institutes of Health that 60.3 ...
Adkins, Amy   +3 more
core   +1 more source

Branched chain aldehydes: production and breakdown pathways and relevance for flavour in foods [PDF]

open access: yes, 2009
Branched aldehydes, such as 2-methyl propanal and 2- and 3-methyl butanal, are important flavour compounds in many food products, both fermented and non-fermented (heat-treated) products. The production and degradation of these aldehydes from amino acids
Engels, W.J.M., Smit, B.A., Smit, G.
core   +2 more sources

Thermoresponsive BrushGel Microcarriers for Efficient Cell Expansion and Enzyme‐Reduced Harvesting

open access: yesAdvanced Healthcare Materials, EarlyView.
Askari et al, report on temperature‐responsive microcarriers to minimize enzyme use and cost in dynamic cultures. Abstract Scaling up cell therapy requires efficient expansion of high‐quality cells. Microcarrier(MC)‐based systems offer high surface‐to‐volume ratios and reduce culture media usage.
Esfandyar Askari   +9 more
wiley   +1 more source

Ethanol-Induced Hepatotoxicity and Alcohol Metabolism Regulation by GABA-Enriched Fermented Smilax china Root Extract in Rats

open access: yesFoods, 2021
Chronic alcohol consumption can cause hepatic injury and alcohol-induced toxicities. Extracts from Smilax china root have been widely used in traditional medicine and for their potential pharmacological benefits. We aimed to determine if fermented Smilax
Naila Boby   +7 more
doaj   +1 more source

Site directed mutagenesis and purification of the cDNA for human class I aldehyde dehydrogenase : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science at Massey University [PDF]

open access: yes, 1998
Aldehyde dehydrogenase (ALDH) is a key enzyme of alcohol metabolism, removing acetaldehyde which is formed as a product of the alcohol dehydrogenase reaction.
Wansbrough, Erin M
core  

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

open access: yesAdvanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq   +4 more
wiley   +1 more source

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