Results 81 to 90 of about 2,165,233 (395)

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats. [PDF]

, 2019
The activation of a neuronal ensemble in the central nucleus of the amygdala (CeA) during alcohol withdrawal has been hypothesized to induce high levels of alcohol drinking in dependent rats.
Crawford, Elena, de Guglielmo, Giordano, George, Olivier, Kallupi, Marsida, Koob, George F, Messing, Robert O, Pomrenze, Matthew B, Schweitzer, Paul, Simpson, Sierra   +8 more
core   +2 more sources

Patterns of Alcohol Use and Alcohol Use Disorders and Their Sociodemographic Correlates: Findings from a Cross sectional Study among Male Patients Attending a NIA Outpatient Department

Journal of Ayurveda
Introduction: Alcohol consumption is a significant public health issue, contributing to substantial morbidity and mortality worldwide. In India, alcohol use prevalence ranges from 3.8% to 21%, predominantly affecting men. Despite estimates of alcohol use
Viadya Amol S. Kadu, Rupali D. Asutkar, Anita Sharma, R. K. N. Priyangika   +3 more
doaj   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Neurophysiological Measures and Alcohol Use Disorder (AUD): Hypothesizing Links between Clinical Severity Index and Molecular Neurobiological Patterns [PDF]

, 2014
In 1987, Cloninger proposed a clinical description and classification of different personality traits genetically defined and independent from each other. Moreover, he elaborated a specific test the TCI to investigate these traits/states.
Attilia, Maria Luisa, Battagliese, Gemma, Berman, Marlene Oscar, Blum, Kenneth, Braverman, Eric R, Ceccanti, Mauro, Minuto, Simona Flamminii, Napolitano, Carmen, Romeo, Marina, Vitali, Mario   +9 more
core   +1 more source

Trauma exposure and alcohol use disorder among prisoners in Jimma Zone correctional institution, Southwest Ethiopia: a cross-sectional study

BMC Research Notes, 2019
Objective Trauma exposure and alcohol use are closely related, and large proportion of trauma-exposed individuals use alcohol. The data presented in this paper were obtained as part of a study on substance use disorder and associated factors among ...
Yimenu Yitayih, Matiwos Soboka, Elias Tesfaye, Mubarek Abera, Almaz Mamaru, Kristina Adorjan   +5 more
doaj   +1 more source

Prevalence of major depressive disorder among wives of men with alcohol use disorder-a cross-sectional study from a tertiary care hospital

Kerala Journal of Psychiatry, 2021
Background: Alcohol Use Disorder is highly prevalent in India. Alcohol acts as a continuous stressor, with several stressfull consequences on the wife.
Vijunath Thilakan, Krishnan Sivasubramoney, Mili Babu   +2 more
doaj   +1 more source

Alcohol Use Disorder

, 2012
Millions of individuals use alcohol every day; however, not everyone experiences a problem due to such use. It is therefore helpful to conceptualize alcohol use as ranging on a continuum from nonproblematic social use (e.g., a glass of wine with dinner); to alcohol misuse (e.g., a one-time incident of binge drinking); to excessive use or abuse (e.g ...
Stanley (Shlomo) Einstein, Shulamith Lala Ashenberg Straussner, Sarina Beth Straussner   +2 more
openaire   +2 more sources

Parental alcohol use disorders and alcohol use and disorders in offspring: a community study

Psychological Medicine, 2002
Background. We examined the association between parental alcohol use disorders and patterns of alcohol consumption and DSM-IV alcohol use disorders in their offspring in a community-based sample of young adults.Methods. Data are based on baseline and 4-year follow-up data of 2427 respondents aged 14–24 at baseline.
Lieb, R., Merikangas, K. R., Höfler, M., Pfister, H., Isensee, B., Wittchen, H.-U.   +5 more
openaire   +5 more sources

Liver‐specific lncRNAs associated with liver cancers

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina, Roman K. Makarchenko, Maria P. Rubtsova, Olga A. Dontsova   +3 more
wiley   +1 more source