Results 61 to 70 of about 16,674,550 (294)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Predictors of Alcohol Use Disorder: MAOA Gene VNTR Polymorphism, Impulsivity, and Personality Traits

, 2021
Objective: Risk factors for alcohol use disorder have been investigated for a long time. The MAOA gene presents several polymorphisms, including 30-bp variable number tandem repeat sequences (VNTR) in the promoter region.
Hasan Kaya, Cavus, Raziye Sercin Yalcin, Enez Darcin, Asli, Kaya, Hasan, Nesrin Dilbaz, Civan Kahve, AYBENİZ, Kaya, Ozlem Bolat, Sercin Yalcin Cavus, Raziye, Darcin, Asli Enez, Raziye Sercin Yalcin Cavus, Kahve, Aybeniz Civan, Dilbaz, Nesrin, Asli Enez Darcin, Ozlem Bolat Kaya, DİLBAZ, Hilmiye Nesrin, Aybeniz Civan Kahve, Bolat Kaya, Ozlem   +16 more
core   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Aggressive behavior in adolescents with fetal alcohol spectrum disorders [PDF]

, 2013
Includes bibliographical references.Behavioral studies of fetal alcohol spectrum disorders (FASD) have indicated that aggression is common amongst alcohol-exposed adolescents, and that it appears to become more prevalent with age in that population. Such
Smith, Keelie
core   +1 more source

Transcranial Magnetic Stimulation as a Tool to Promote Smoking Cessation and Decrease Drug and Alcohol Use

Brain Sciences, 2023
Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive, drug-free, neural-circuit-based therapeutic tool that was recently cleared by the United States Food and Drug Associate for the treatment of smoking cessation.
Tal Harmelech, Colleen A. Hanlon, Aron Tendler   +2 more
doaj   +1 more source

Partner alcohol use, violence and women's mental health: population-based survey in India. [PDF]

, 2010
BACKGROUND: The relationship between partner alcohol use and violence as risk factors for poor mental health in women is unclear. AIMS: To describe partner-related and other psychosocial risk factors for common mental disorders in women and examine ...
Bond, Jason C, Nayak, Madhabika B, Patel, Vikram, Greenfield, Thomas K   +3 more
core   +1 more source

Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder. [PDF]

, 2021
Alcohol use disorder (AUD) and schizophrenia (SCZ) frequently co-occur, and large-scale genome-wide association studies (GWAS) have identified significant genetic correlations between these disorders.We used the largest published GWAS for AUD (total ...
Kapoor, Manav, Pato, Michele T, Kember, Rachel L, Meyers, Jacquelyn L, Kranzler, Henry R, Bigdeli, Tim B, Hartz, Sarah, Pato, Carlos N, Edenberg, Howard J, Goate, Alison M, Walters, James T R, Agrawal, Arpana, Walters, Raymond K, Zhou, Hang, Lai, Dongbing, Hatoum, Alexander S, Wendt, Frank R, Peterson, Roseann E, Johnson, Emma C, Ripke, Stephan, Polimanti, Renato, Gelernter, Joel, Fanous, Ayman H, O'Donovan, Michael C   +23 more
core   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Trauma exposure and alcohol use disorder among prisoners in Jimma Zone correctional institution, Southwest Ethiopia: a cross-sectional study

BMC Research Notes, 2019
Objective Trauma exposure and alcohol use are closely related, and large proportion of trauma-exposed individuals use alcohol. The data presented in this paper were obtained as part of a study on substance use disorder and associated factors among ...
Yimenu Yitayih, Matiwos Soboka, Elias Tesfaye, Mubarek Abera, Almaz Mamaru, Kristina Adorjan   +5 more
doaj   +1 more source

Animal Models Used to Study Alcohol Use Disorder

, 2023
For ethical and technical reasons, research in humans has some limitations and requires the support of animal models. Numerous animal models have been developed over the years to study alcohol consumption and model alcohol-related behaviors in several ...
Coppola, Andrea,, Augier, Eric,, Lguensat, Asmae,   +2 more
core   +1 more source