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Risk factors for incidence and persistence of disability in chronic major depression and alcohol use disorders: longitudinal analyses of a population-based study [PDF]

, 2014
BackgroundMajor depression and alcohol use disorders are risk factors for incidence of disability. However, it is still unclear whether a chronic course of these health conditions is also prospectively associated with incidence of disability.
José Luis Ayuso-Mateos, Ayuso-Mateos, J., Cieza, A., Alarcos Cieza, Chatterji, S., Cabello, M., Caballero, F., Somnath Chatterji, María Cabello, Francisco Félix Caballero   +9 more
core   +1 more source

Alcohol Misuse and Alcohol Use Disorder in Adolescents

Addicta: The Turkish Journal on Addictions
Adolescence is a distinct developmental stage marked by increased levels of novelty-seeking, reward sensitiv- ity, and risk-taking behaviors, which often heighten the risk for alcohol use.
İpek Süzer Gamlı, Mehmet Can Erata
doaj   +1 more source

Alcohol use disorder and its determinant factors among patients with schizophrenia attending treatment at mental specialized hospital, Addis Ababa, Ethiopia: A cross-sectional study

SAGE Open Medicine, 2021
Background: Alcohol use disorder is one of the primary causes of avoidable death, illness, and injury in many societies throughout the world. Although alcohol use disorder can influence the natural history of a disease, disease recurrence, quality of ...
Habtamu Tadesse, Yohannes Mirkena Lemu, Tadesse Misgana   +2 more
doaj   +1 more source

RNA biomarkers for alcohol use disorder

Frontiers in Molecular Neuroscience, 2022
Alcohol use disorder (AUD) is highly prevalent and one of the leading causes of disability in the US and around the world. There are some molecular biomarkers of heavy alcohol use and liver damage which can suggest AUD, but these are lacking in ...
Laura B. Ferguson, Laura B. Ferguson, Laura B. Ferguson, R. Dayne Mayfield, R. Dayne Mayfield, Robert O. Messing, Robert O. Messing, Robert O. Messing   +7 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Alcohol use disorders and ADHD

Neuroscience & Biobehavioral Reviews, 2021
Despite a growing literature on the complex bidirectional relationship of ADHD and substance use, reviews specifically focusing on alcohol are scarce. ADHD and AUD show a significant genetic overlap, including genes involved in gluatamatergic and catecholaminergic neurotransmission.
Mathias Luderer, Josep Antoni Ramos Quiroga, Stephen V. Faraone, Yanli Zhang-James, Andreas Reif   +4 more
openaire   +2 more sources

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source

Patterns of Alcohol Use and Alcohol Use Disorders and Their Sociodemographic Correlates: Findings from a Cross sectional Study among Male Patients Attending a NIA Outpatient Department

Journal of Ayurveda
Introduction: Alcohol consumption is a significant public health issue, contributing to substantial morbidity and mortality worldwide. In India, alcohol use prevalence ranges from 3.8% to 21%, predominantly affecting men. Despite estimates of alcohol use
Viadya Amol S. Kadu, Rupali D. Asutkar, Anita Sharma, R. K. N. Priyangika   +3 more
doaj   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source