Results 41 to 50 of about 16,075,891 (296)

RNA biomarkers for alcohol use disorder

Frontiers in Molecular Neuroscience, 2022
Alcohol use disorder (AUD) is highly prevalent and one of the leading causes of disability in the US and around the world. There are some molecular biomarkers of heavy alcohol use and liver damage which can suggest AUD, but these are lacking in ...
Laura B. Ferguson, Laura B. Ferguson, Laura B. Ferguson, R. Dayne Mayfield, R. Dayne Mayfield, Robert O. Messing, Robert O. Messing, Robert O. Messing   +7 more
doaj   +1 more source

Alcohol Misuse and Alcohol Use Disorder in Adolescents

Addicta: The Turkish Journal on Addictions
Adolescence is a distinct developmental stage marked by increased levels of novelty-seeking, reward sensitiv- ity, and risk-taking behaviors, which often heighten the risk for alcohol use.
İpek Süzer Gamlı, Mehmet Can Erata
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Alcohol use disorder and its determinant factors among patients with schizophrenia attending treatment at mental specialized hospital, Addis Ababa, Ethiopia: A cross-sectional study

SAGE Open Medicine, 2021
Background: Alcohol use disorder is one of the primary causes of avoidable death, illness, and injury in many societies throughout the world. Although alcohol use disorder can influence the natural history of a disease, disease recurrence, quality of ...
Habtamu Tadesse, Yohannes Mirkena Lemu, Tadesse Misgana   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Patterns of Alcohol Use and Alcohol Use Disorders and Their Sociodemographic Correlates: Findings from a Cross sectional Study among Male Patients Attending a NIA Outpatient Department

Journal of Ayurveda
Introduction: Alcohol consumption is a significant public health issue, contributing to substantial morbidity and mortality worldwide. In India, alcohol use prevalence ranges from 3.8% to 21%, predominantly affecting men. Despite estimates of alcohol use
Viadya Amol S. Kadu, Rupali D. Asutkar, Anita Sharma, R. K. N. Priyangika   +3 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Transcranial Magnetic Stimulation as a Tool to Promote Smoking Cessation and Decrease Drug and Alcohol Use

Brain Sciences, 2023
Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive, drug-free, neural-circuit-based therapeutic tool that was recently cleared by the United States Food and Drug Associate for the treatment of smoking cessation.
Tal Harmelech, Colleen A. Hanlon, Aron Tendler   +2 more
doaj   +1 more source

Alcohol use disorders and ADHD

Neuroscience & Biobehavioral Reviews, 2021
Despite a growing literature on the complex bidirectional relationship of ADHD and substance use, reviews specifically focusing on alcohol are scarce. ADHD and AUD show a significant genetic overlap, including genes involved in gluatamatergic and catecholaminergic neurotransmission.
Mathias Luderer, Josep Antoni Ramos Quiroga, Stephen V. Faraone, Yanli Zhang-James, Andreas Reif   +4 more
openaire   +2 more sources