Results 41 to 50 of about 122,587 (295)

Alcohol Withdrawal Simulation Case

MedEdPORTAL, 2010
This is a simulation case involving a patient presenting to the emergency room with symptoms of alcohol withdrawal. It is intended for the education of emergency medicine residents, internal medicine residents, family practice residents, or medical ...
Pierre Detiege
doaj   +1 more source

Problematisation and regulation: bodies, risk, and recovery within the context of Neonatal Abstinence Syndrome [PDF]

, 2018
Background Neonatal Abstinence Syndrome (NAS) is an anticipated effect of maternal drug use during pregnancy. Yet it remains a contested area of policy and practice.
Chandler, Amy, Cooper, Sarah, Cunningham-Burley, Sarah, Elliott, Lawrie, Midgley, Paula, Whittaker, Anne   +5 more
core   +3 more sources

Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

Advanced Science, EarlyView.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun, Jiancheng Pan, Rui Li, Ruoxi Li, Ziyan Liu, Jinhui Wu, Tingsheng Lin, Yiqiao Hu, Ahu Yuan   +8 more
wiley   +1 more source

CRISPLD2 Attenuates Intervertebral Disc Degeneration by Suppressing Oxidative Stress‐Induced Ferroptosis through the miR‐548I‐IL17A Axis

Advanced Science, EarlyView.
This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi, Fudong Li, Tianyi Zhao, Kaiqiang Sun, Danying Zhang, Chen Yan, Ximing Xu, Jingchuang Sun, Xulin Hu, Xin Yong, Jiangang Shi, Yuan Wang   +11 more
wiley   +1 more source

Gamma-hydroxybutyrate abuse: pharmacology and poisoning and withdrawal management

Arhiv za Higijenu Rada i Toksikologiju, 2020
Gamma-hydroxybutyrate (GHB) is a central nervous system depressant primarily used as a recreational drug of abuse, but also for the treatment of narcolepsy with cataplexy in adult patients and as an adjuvant for control of alcohol withdrawal syndrome ...
Marinelli Enrico, Beck Renata, Malvasi Antonio, Faro Alfredo Fabrizio Lo, Zaami Simona   +4 more
doaj   +1 more source

Clinical and genetic associations of the CLOCK circadian rhythm gene and depressive disorders in patients with alcohol dependence syndrome during the period of alcohol abstinence

Неврология, нейропсихиатрия, психосоматика, 2022
About 20% of patients with depression are diagnosed with alcohol dependence, and alcohol dependent individuals are at a higher risk of developing depression.
N. R. Tulbaeva, R. F. Nasyrova, D. A. Smirnova, Z. Sh. Ashurov, I. S. Efremov, V. S. Dobrodeeva, A. E. Abdrakhmanova, A. R. Asadullin   +7 more
doaj   +1 more source

Update on medication-overuse headache and its treatment [PDF]

, 2015
OPINION STATEMENT: Medication-overuse headache-i.e., a too-frequent consumption of acute headache medications leading to increased headache frequency and reduced effectiveness of acute and preventive treatments-is a serious medical condition whose ...
Giamberardino MA, MARTELLETTI, Paolo, Mitsikostas DD   +2 more
core   +1 more source

Oral Celastrol Nanomedicine Targeting Intestinal Antigen‐Presenting Cells to Effectively Mitigate Autoimmune Uveitis via Gut‐Retina Axis

Advanced Science, EarlyView.
Oral nanoCEL exhibits effective intestinal targeting of antigen‐presenting cells and restores the Th17/Treg balance in lymph nodes and spleen, ultimately protecting the blood‐retinal barrier by inhibiting peripheral immune cell infiltration and suppressing retinal glial cell activation.
Jinrun Chen, Yuqin Wu, Bofei Xu, Jiabei Hou, Yijing Li, Yuhan Hu, Yutuo Zhu, Wenqiao Zhang, Shuqi Feng, Huanting Jin, Yuchen Cheng, Yuanyuan Jin, Jianhong Zhou, Xingyi Li   +13 more
wiley   +1 more source

Analysis of heart rate variability in patients with chronic alcohol abuse

Journal of Education, Health and Sport, 2015
Article represents the results of studies on the use of the method of assessment of heart rate variability in patients with alcohol withdrawal syndrome without delirious syndrome and in patients with the condition as a result of alcohol withdrawal with ...
A. I. Gozhenko, V. A. Petrov
doaj   +3 more sources

Protective effect of Ocimum sanctum Linn. leaf extract on ethanol withdrawal syndrome in Wistar rats

Asian Pacific Journal of Tropical Medicine, 2018
Objective: To evaluate the effects of Oscimum sanctum L (O. sanctum), an important medicinal herb, on alcohol withdrawal syndrome in Wistar rats. Methods: Liquid diet with 7.2%, v/v ethanol was administered to the rats for 21 d.
Lalit Sharma, Aditi Sharma, G L Gupta, Gopal Singh Bisht   +3 more
doaj   +1 more source