Results 111 to 120 of about 387,299 (303)

Inhibition of connexin hemichannels alleviates non-alcoholic steatohepatitis in mice

Scientific Reports, 2017
While gap junctions mediate intercellular communication and support liver homeostasis, connexin hemichannels are preferentially opened by pathological stimuli, including inflammation and oxidative stress.
Joost Willebrords, Bruno Cogliati, Isabel Veloso Alves Pereira, Tereza Cristina da Silva, Sara Crespo Yanguas, Michaël Maes, Veronica Mollica Govoni, Andressa Lima, Daniele Aparecida Felisbino, Elke Decrock, Marina Sayuri Nogueira, Inar Alves de Castro, Isabelle Leclercq, Luc Leybaert, Robim Marcelino Rodrigues, Mathieu Vinken   +15 more
doaj   +1 more source

Acute steatohepatitis, due to extreme metabolic dysregulation, as the first presentation of non-alcoholic fatty liver disease

Clinics and Practice, 2013
Non-alcoholic fatty liver disease (NAFLD) is a slowly progressive chronic disease, with a high prevalence among obese, dyslipidemic or diabetic people, commonly presented as an asymptomatic mild elevation of serum aminotransferases.
Georgios Kranidiotis, Angeliki Angelidi, Emmanouel Sevdalis, Thomas-Nikolaos Telios, Alexandra Gougoutsi, Andreas Melidonis   +5 more
doaj   +1 more source

Chronic Inflammation in Non-Alcoholic Steatohepatitis: Molecular Mechanisms and Therapeutic Strategies

Frontiers in Endocrinology, 2020
Non-Alcoholic Steatohepatitis (NASH) is the progressive form of Non-Alcoholic Fatty Liver Disease (NAFLD), the main cause of chronic liver complications.
C. Luci, Manon Bourinet, Pierre S. Leclère, R. Anty, P. Gual   +4 more
semanticscholar   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

CAQ Corner: Immune‐mediated complications

, 2022
Liver Transplantation, EarlyView.
Mary Thomson, John R. Lake
wiley   +1 more source

The alteration of immune cells in the pathogenesis of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis

Liver Research, 2020
The prevalence of non-alcoholic fatty liver disease (NAFLD) increases rapidly in recent decades. NAFLD has become a major public health problem in China and the whole world, and it is considered as the main cause for the chronic liver diseases.
Dechun Feng
doaj   +1 more source

Ferroptosis affects the progression of non-alcoholic steatohepatitis via the modulation of lipid peroxidation-mediated cell death in mice.

American Journal of Pathology, 2019
Oxidative stress and its-associated lipid peroxidation play a key role in non-alcoholic steatohepatitis (NASH). Ferroptosis is a recently recognized type of cell death characterized by an iron dependent and lipid peroxidation-mediated non-apoptotic cell ...
Jing Qi, Jong-Won Kim, Zi-Xiong Zhou, C. Lim, Bumseok Kim   +4 more
semanticscholar   +1 more source

Cost of non-alcoholic steatohepatitis in Europe and the USA: The GAIN study

JHEP Reports, 2020
Background & Aims Non-alcoholic steatohepatitis (NASH) leads to cirrhosis and is associated with a substantial socioeconomic burden, which, coupled with rising prevalence, is a growing public health challenge.
J. O'Hara, A. Finnegan, H. Dhillon, Leonardo Ruiz-Casas, G. Pedra, B. Franks, G. Morgan, Vanessa Hebditch, B. Jönsson, M. Mabhala, T. Reić, I. van Thiel, V. Ratziu, M. Romero-Gómez, E. Bugianesi, J. Schattenberg, Q. Anstee   +16 more
semanticscholar   +1 more source

Postoperative association between impaired renal function and vascular dysfunction in liver transplant recipients

, 2022
Liver Transplantation, EarlyView.
Domenico A. Chavez, Marie‐Claire Evans, Natalie J. Bohmke, Hiba Kamal, Loan Quynh Tran, Chandra Bhati, Susan Wolver, Mohammad S. Siddiqui, Danielle L. Kirkman   +8 more
wiley   +1 more source

Inflammatory Pathways in Alcoholic Steatohepatitis

Journal of Hepatology, 2019
Inflammatory processes are primary contributors to the development and progression of alcoholic steatohepatitis (ASH), with severe alcoholic hepatitis (AH) characterized by non- resolving inflammation.
B. Gao, Maleeha F. Ahmad, L. Nagy, H. Tsukamoto   +3 more
semanticscholar   +1 more source