Results 121 to 130 of about 387,299 (303)

Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis

Gut, 2020
Objective Lipotoxic hepatocyte injury is a primary event in non-alcoholic steatohepatitis (NASH), but the mechanisms of lipotoxicity are not fully defined.
E. Koh, Ji Eun Yoon, M. Ko, Jaechan Leem, Ji-Young Yun, Chung Hwan Hong, Y. Cho, Seung Eun Lee, J. Jang, J. Baek, H. Yoo, Su Jung Kim, C. Sung, Joon Seo Lim, W. Jeong, S. Back, In-Jeoung Baek, S. Torres, E. Solsona-Vilarrasa, Laura Conde de la Rosa, C. Garcia-Ruiz, A. Feldstein, J. Fernández-Checa, Ki-Up Lee   +23 more
semanticscholar   +1 more source

Liver biopsy in alcoholic and non-alcoholic steatohepatitis patients

, 2009
Alcoholic liver disease and non-alcoholic liver disease share a similar histological spectrum that starts with 'simple' steatosis, and may be accompanied by inflammation.
Tiniakos, D.G.
core   +1 more source

Postprandial Dysmetabolism and Non-Alcoholic Fatty Liver Disease in Relation to Type 2 Diabetes Mellitus and Cardiovascular Risk [PDF]

, 2007
Het aantal gevallen van “ouderdomssuikerziekte” (type 2 diabetes mellitus) neemt in de Westerse wereld snel toe als gevolg van veranderingen in leefstijl (verhoogde consumptie van vet- en energierijke voeding en verminderde lichaamsbeweging), en als ...
Schindhelm, R.K.
core   +5 more sources

Non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH)-related liver fibrosis: mechanisms, treatment and prevention

Annals of Translational Medicine, 2020
Liver fibrosis is the excessive expression and accumulation of extracellular matrix proteins in the liver. Fibrotic scarring occurs as the consequence of chronic injury and inflammation.
F. Tacke, R. Weiskirchen
semanticscholar   +1 more source

Insulin‐like growth factor‐1 is inversely associated with liver fibrotic markers in patients with type 2 diabetes mellitus

Journal of Diabetes Investigation, 2019
Aims/Introduction Insulin‐like growth factor‐1 (IGF‐1) regulates mitochondrial function, oxidative stress, inflammation, stellate cells and insulin sensitivity in the liver, and it might be associated with liver fibrosis from non‐alcoholic ...
Shozo Miyauchi, Teruki Miyake, Masumi Miyazaki, Toru Eguchi, Tetsuji Niiya, Shin Yamamoto, Hidenori Senba, Shinya Furukawa, Bunzo Matsuura, Yoichi Hiasa   +9 more
doaj   +1 more source

Non-Alcoholic Steatohepatitis in Myotonic Dystrophy: DMPK Gene Mutation, Insulin Resistance and Development of Steatohepatitis

Case Reports in Gastroenterology, 2010
Myotonic dystrophy is a multisystemic disorder characterized by repeat expansion mutations of the dystrophia myotonica protein kinase (DMPK) gene resulting in a defective muscular insulin receptor and insulin resistance.
Rishi R. Bhardwaj, Andrea Duchini
doaj   +1 more source

The Role of the Histone Methyltransferase EZH2 in Liver Inflammation and Fibrosis in STAM NASH Mice

Biology, 2020
Non-alcoholic fatty liver disease (NAFLD) is a leading form of chronic liver disease, with few biomarkers and treatment options currently available. Non-alcoholic steatohepatitis (NASH), a progressive disease of NAFLD, may lead to fibrosis, cirrhosis ...
Seul Lee, Dong-Cheol Woo, Jeeheon Kang, Moonjin Ra, Ki Hyun Kim, Seoung Rak Lee, Dong Kyu Choi, Heejin Lee, Ki Bum Hong, Sang-Hyun Min, Yongjun Lee, Ji Hoon Yu   +11 more
doaj   +1 more source

NASH: Non-Alcoholic Steatohepatitis [PDF]

, 2015
Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease which refers to the presence of hepatic steatosis without significant intake of alcohol.
Heck, Jennifer
core  

The role of blood groups in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis

, 2017
Introduction: Non-alcoholic fatty liver disease is defined as the accumulation of fat in the liver in the absence of excessive alcohol consumption or other known pathologies and is a spectrum of disease ranging from steatosis (fat infiltration into the ...
Arik, Ferhat, Gencer, Vedat, Gorkem, Hasan, Karaman, Hatice, Erden, ABDULSAMET, Kalan, Ugur, Karaman, Ahmet, Avci, Deniz, Karagoz, Hatice, Cetinkaya, Ali, Ozer, Ozerhan   +10 more
core   +1 more source

Effects of sex and race on the changes in intrahepatic lipid, total and visceral adipose tissue in response to exercise training in obese adolescents [PDF]

, 2013
BACKGROUD: Non-alcoholic fatty liver is the most frequent liver abnormality observed in obese children and adolescents. It is has yet to be determined whether sex and race plays a role in the effect of regular exercise without calorie restriction on ...
Deldin, Anthony
core