Results 261 to 270 of about 387,299 (303)

Correction: Geniposide plus chlorogenic acid reverses non-alcoholic steatohepatitis via regulation of gut microbiota and bile acid signaling in a mouse model <i>in vivo</i>. [PDF]

Front Pharmacol
Li H, Xi Y, Xin X, Feng Q, Hu Y.
europepmc   +1 more source

Direct Pharmacological Activation of AMPK Extends Lifespan in Yeast, Worms and Flies

Aging Cell, Volume 25, Issue 10, October 2026.
AMP‐activated protein kinase (AMPK) is a key evolutionarily conserved sensor of energy homeostasis, which is implicated in metabolic health and disease, as well as in ageing. Here, we show that direct pharmacological activation of AMPK with the compound 991 in vivo extends lifespan in multiple model organisms: the fission yeast Schizosaccharomyces ...
Eliano dos Santos, Marie Blickling, Fiona C. Leiper, John‐Patrick Alao, Claudia Lennicke, Andrea Foley, Jon R. Wilson, Steven J. Gamblin, Bénédicte Chazaud, Giovanna Lollo, Rémi Mounier, Gaëtan Juban, Charalampos Rallis, David Carling, Filipe Cabreiro, Helena M. Cochemé   +15 more
wiley   +1 more source

Correction: Steatosis is involved in the progression of kidney disease in a high-fat-diet-induced non-alcoholic steatohepatitis mouse model. [PDF]

PLoS One
PLOS One Staff.
europepmc   +1 more source

Meta‐Analysis: Enhanced Liver Fibrosis (ELF) Test for Identifying Significant Fibrosis, Advanced Fibrosis, and Cirrhosis in Patients With Metabolic Dysfunction‐Associated Steatotic Liver Disease

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 7, Page 864-889, October 2026.
A metaanalysis of 34 studies/37 cohorts using the Siemens Healthineers ELF test for biopsy‐staged F2, F3, or F4 MASLD‐associated fibrosis validates 9.0 (≥F2), 9.8 (≥F3), and 11.3 (F4) cut‐offs, and establishes 10.5 as a high‐specificity F4 cut‐off. This potentially holds implications for guideline revisions and aiding qualification for antifibrotic ...
Matthew F. W. Gee, Donald B. Chalfin, Edward B. De Vol, H. Roma Levy, Artem T. Boltyenkov, Mario Gutierrez Casale, Arun J. Sanyal   +6 more
wiley   +1 more source

Identification of biomarkers between coronary artery disease and non-alcoholic steatohepatitis: a combination of bioinformatics and machine learning. [PDF]

Front Genet
Lin Y, Song J, Li X.
europepmc   +1 more source

Transcriptomic and metabolomic analyses reveal that lobeglitazone ameliorates hepatic steatosis in rats concurrent with regulation of mitochondrial pyruvate metabolism

British Journal of Pharmacology, Volume 183, Issue 19, Page 5935-5952, October 2026.
Background and Purpose Lobeglitazone is a thiazolidinedione and PPARγ agonist that improves metabolic parameters and hepatic steatosis, but its mechanisms are not fully understood. This study investigated the effects of lobeglitazone on hepatic transcriptomic and metabolic profiles in a rat model of obesity and Type 2 diabetes mellitus.
Hyekyung Yang, Su Young Son, Youngmi Song, Hyewon Choi, In‐Gu Do, Choong Hwan Lee, Cheol‐Young Park   +6 more
wiley   +1 more source

Rezdiffra™ (resmetirom): a THR-β agonist for non-alcoholic steatohepatitis. [PDF]

Trends Pharmacol Sci
Brisnovali NF, Haney C, Goedeke L.
europepmc   +1 more source

Discovery of Epidermal Growth Factor‐Like 7 as a Potential Non‐Invasive Biomarker for Fibrosis and Mortality Risk in MASLD

Clinical and Translational Science, Volume 19, Issue 10, October 2026.
Proteomic discovery and validation of EGFL7 as a potential non‐invasive biomarker in MASLD. EGFL7 was identified as the top‐ranked proteomic feature in a clinical cohort, demonstrated diagnostic performance comparable to FIB‐4 for fibrosis assessment, and was associated with increased all‐cause mortality risk in the UK Biobank.
Heather Collis, Sara F. Hansson, Patrik Nasr, Cecilia Jönsson, Mathias Liljeblad, Björn Carlsson, Showgy Ma'ayeh, Boxi Zhang, Jana de Wiljes, Mattias Ekstedt, Stergios Kechagias, Jane Knöchel   +11 more
wiley   +1 more source

Butein Alleviates Non-Alcoholic Steatohepatitis in Leptin-Deficient Mice by Modulating the PDE4/cAMP/p-CREB Pathway. [PDF]

Drug Des Devel Ther
Guo C, Zhang Y, Xue H, Zhao X, Wang B, Deng L, Zhu X, Zhang X, Zhang Y, Liu Y.   +9 more
europepmc   +1 more source

Ethanol extract of Polygonatum cyrtonema Hua mitigates non-alcoholic steatohepatitis in mice. [PDF]

Front Pharmacol
Chen D, Shen Y, Huang F, Huang B, Xu S, Li L, Liu J, Li Z, Li X.   +8 more
europepmc   +1 more source