Results 71 to 80 of about 387,299 (303)

Protective Properties of FOXO1 Inhibition in a Murine Model of Non-alcoholic Fatty Liver Disease Are Associated With Attenuation of ER Stress and Necroptosis

Frontiers in Physiology, 2020
AimThe pathogenesis of non-alcoholic fatty liver disease is currently unclear, however, lipid accumulation leading to endoplasmic reticulum stress appears to be pivotal in the process. At present, FOXO1 is known to be involved in NAFLD progression.
Hao-ran Ding, Hao-ran Ding, Hao-ran Ding, Zhen-ting Tang, Ning Tang, Zheng-yi Zhu, Han-yi Liu, Chen-yan Pan, An-yin Hu, Yun-zhen Lin, Peng Gou, Xian-wen Yuan, Jia-hui Cai, Chun-long Dong, Jing-lin Wang, Jing-lin Wang, Jing-lin Wang, Hao-zhen Ren, Hao-zhen Ren, Hao-zhen Ren   +19 more
doaj   +1 more source

Rapid development of non-alcoholic steatohepatitis in Psammomys obesus (Israeli sand rat). [PDF]

PLoS ONE, 2014
BACKGROUND AND AIMS: A major impediment to establishing new treatments for non-alcoholic steatohepatitis is the lack of suitable animal models that accurately mimic the biochemical and metabolic characteristics of the disease.
Briana Spolding, Timothy Connor, Carrie Wittmer, Lelia L F Abreu, Antony Kaspi, Mark Ziemann, Gunveen Kaur, Adrian Cooper, Shona Morrison, Scott Lee, Andrew Sinclair, Yann Gibert, James L Trevaskis, Jonathon D Roth, Assam El-Osta, Richard Standish, Ken Walder   +16 more
doaj   +1 more source

Two-dimensional shear wave elastography and ultrasound-guided attenuation parameter for progressive non-alcoholic steatohepatitis.

PLoS ONE, 2021
Background and aimsWe investigated the usefulness of combining two-dimensional shear wave elastography and the ultrasound-guided attenuation parameter for assessing the risk of progressive non-alcoholic steatohepatitis, defined as non-alcoholic ...
Hidekatsu Kuroda, Yudai Fujiwara, Tamami Abe, Tomoaki Nagasawa, Takuma Oguri, Sachiyo Noguchi, Naohisa Kamiyama, Yasuhiro Takikawa   +7 more
doaj   +1 more source

Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis.

Immunity, 2020
Kupffer cells (KCs) are liver-resident macrophages that self-renew by proliferation in the adult independently from monocytes. However, how they are maintained during non-alcoholic steatohepatitis (NASH) remains ill defined.
S. Tran, I. Baba, L. Poupel, Sébastien Dussaud, M. Moreau, Adélaïde Gélineau, G. Marcelin, Elissa Magréau-Davy, Melissa Ouhachi, P. Lesnik, A. Boissonnas, W. Le Goff, B. Clausen, L. Yvan-Charvet, F. Sennlaub, T. Huby, E. Gautier   +16 more
semanticscholar   +1 more source

Therapeutic Targeting of Hepatic ACSL4 Ameliorates Non-alcoholic Steatohepatitis in Mice

Hepatology, 2021
Globally, NAFLD is one of the most common liver disorders, with an estimated prevalence rate of more than 30% in men and 15% in women and an even higher prevalence in people with type 2 diabetes mellitus.
J. Duan, Zhuo Wang, R. Duan, Chen-Xi Yang, Ruolin Zhao, Q. Feng, Yuan-yuan Qin, Jing-Wei Jiang, Shou-Yong Gu, Kaiyan Lv, Li-Bo Zhang, Bixia He, L. Birnbaumer, Song Yang, Zhen Chen, Yong Yang   +15 more
semanticscholar   +1 more source

Alcoholic steatohepatitis

, 2010
Severe alcoholic steatohepatitis has a poor prognosis and is characterized by jaundice and signs of liver failure. Its incidence is unknown, but prevalence is around 20% in cohorts of alcoholics undergoing liver biopsy.
Stickel, Felix, Helmut K. Seitz, Seitz, Helmut K, Felix Stickel   +3 more
core   +1 more source

Hepatic Steatosis and Steatohepatitis Is the Inevitability of Mixed Genesis

Gastroenterologìa, 2014
The analysis of the etiological and pathogenetic mechanisms of formation steatosis and steatohepatitis of mixed genesis is presented. It is shown that alcohol remains one of the main etiopathogenetic factors in the development of the hepatic steatosis ...
Yu.M. Stepanov
doaj   +1 more source

Rifaximin in Non-Alcoholic Steatohepatitis: An Open-Label Pilot Study [PDF]

, 2017
Aim Gut microbial dysbiosis is implicated in the pathogenesis of non-alcoholic steatohepatitis (NASH). We investigated downstream effects of gut microbiota modulation on markers of hepatic inflammation, steatosis, and hepatic and peripheral insulin ...
Atkinson, Stephen, Marchesi, Julian R, Julie Stove, Wai, Sann N., Yee, Michael S., Stove, Julie, Goldin, Robert D, Jackson, Nicola, Simon D. Taylor-Robinson, Wai, S.N., Quentin M. Anstee, Holmes, E., Cobbold, Jeremy F.L., Umpleby, A. Margot, Fitzpatrick, Julie, Yee, M.S., Thursz, Mark R., Shojaee-Moradie, Fariba, Fariba Shojaee-Moradie, Umpleby, A.M., Taylor-Robinson, S.D., Holmes, Elaine, Shojaee-Moradie, F., A. Margot Umpleby, Anstee, Quentin M, Thomas, E.L., Ann Smith, Bell, Jimmy D, Fitzpatrick, J., Taylor-Robinson, Simon D, Marchesi, Julian R., Bell, Jimmy D., Thursz, M.R., Goldin, R.D., Julian R. Marchesi, Nicola Jackson, Thursz, Mark R, Atkinson, S., Taylor-Robinson, Simon D., Mark R. Thursz, Anstee, Q.M., Wai, Sann N, Goldin, Robert D., Cobbold, Jeremy FL, Jackson, N.C., Marchesi, Julian Roberto, Julie Fitzpatrick, Smith, A., Thomas, E. Louise, Robert D. Goldin, Stove, J., Smith, Ann, Marchesi, J.R., Jeremy F.L. Cobbold, Umpleby, A Margot, Anstee, Quentin M., Elaine Holmes, Bell, J.D., Stephen Atkinson, Sann N. Wai, E. Louise Thomas, Michael S. Yee, Cobbold, J.F.L., Thomas, E Louise, Yee, Michael S, Jimmy D. Bell   +65 more
core   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Changes in direct markers of liver fibrosis in patients with steatohepatitis non-alcoholic and alcoholic origin on the background of obesity and pathology of the biliary tract

Zaporožskij Medicinskij Žurnal, 2017
The aim of this work is to investigate the direct markers of liver fibrosis (LF) in patients with steatohepatitis non-alcoholic and alcoholic origin in combination with obesity (OB) and pathology of the biliary tract (BT). Materials and Methods.
A. Yu. Filippova
doaj   +1 more source