Results 221 to 230 of about 256,760 (299)

Biocatalytic Carboxylic Acid Reduction and Transamination in Cell-Free Lysates at High Substrate Loading. [PDF]

ChemSusChem
Gopal MR, Corrado NM, Chen W, Kunjapur AM.   +3 more
europepmc   +1 more source

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +1 more source

Functionalization of Position 7 of Pyrazolo[1,5-a]pyrazines

SynOpen
Georgyi Koidan, Nazar Tsyzoryk, Eduard B. Rusanov, Svitlana V. Shishkina, Mykhailo Vovk, Aleksandr Kostyuk   +5 more
doaj   +1 more source

Biphasic Solar Reforming of Lignin to Aromatics and CO for In Situ Carbonylation of Organics. [PDF]

J Am Chem Soc
Mittal D, Mitra S, Bonvin E, Spring DR, Bonke SA, Reisner E.   +5 more
europepmc   +1 more source

Cysteine Thioaldehydes: Photolytic Generation, Reactivity, and Biological Implications

Angewandte Chemie, EarlyView.
Photolysis of cysteine phenacylsulfides bearing non‐conjugating electron‐withdrawing substituents leads to high conversions into cysteine thioaldehydes through a Norrish type‐II pathway. This methodology enabled the study of the aqueous reactivity of these important biosynthetic intermediates, which, depending on peptide sequence, pH and buffer ...
Ardra Karthika, Matthew Murray, Guillermo Palop, Lee‐Ann J. Keane, Patrick McArdle, Nicholas D. J. Yates, Christopher D. Spicer, Alison Parkin, Martin A. Fascione, Eddie L. Myers   +9 more
wiley   +1 more source

Acyl CoA reductases useful for bioproduction of hydrocarbons. [PDF]

Microb Cell Fact
Ito M, Kishino S, Muramatsu M, Ogawa J.
europepmc   +1 more source

Breakthrough Design of Highly Potent Antivirals Against Wild‐Type HIV‐1 and Lenacapavir‐Resistant M66I Variant

Angewandte Chemie, EarlyView.
Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey, D. M. Nirosh Udayanga, Huanchun Zhang, Roshan Katekar, Wei Xie, Shreya M. Ravichandran, Xinyong Cai, Zachary C. Lorson, William M. McFadden, Won Hee Ryu, Jiashu Xie, Karen A. Kirby, Stefan G. Sarafianos, Zhengqiang Wang   +13 more
wiley   +1 more source

Injectable Arnebia Euchroma Polysaccharide-Based Hydrogel as CpG Oligonucleotide Delivery System with Dual Immunomodulatory Activities. [PDF]

Gels
Xiao C, Zhang M, Dan M, Hu Y, Zhao P, Ochir S, Bai W, Bo S.   +7 more
europepmc   +1 more source

De Novo Discovery of Nonstandard Thioisoindole‐Bridged Bicyclic Peptides Targeting Traf2‐ and NCK‐Interacting Kinase

Angewandte Chemie, EarlyView.
An optimized strategy for the ribosomal synthesis of thioisoindole‐bridged bicyclic (TiB) peptides is incorporated into the RaPID platform, enabling high‐throughput discovery from topologically defined TiB libraries. Proof‐of‐concept selection against TNIK identifies nanomolar‐affinity ligands with inhibitory activity, while x‐ray crystallography ...
Yue Zhang, Alexander A. Vinogradov, Keisuke Hamada, Yin Sun, Toru Sengoku, Hiroaki Suga   +5 more
wiley   +1 more source

Water addition to e-liquids to reduce flavour aldehyde acetal formation: chemistry and user sensory experience and appeal. [PDF]

Tob Control
Davis D, Green BG, Krishnan-Sarin S, Martin TD, Wu R, Gueorguieva R, Anastas PT, Zimmerman JB, O'Malley S, Allen W, Erythropel HC.   +10 more
europepmc   +1 more source