Results 101 to 110 of about 135 (134)
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Aldehyde Dehydrogenase in Alcoholic Subjects
Hepatology, 1985Hepatic aldehyde dehydrogenase activity is depressed in alcoholic liver disease and may account for the observation that alcoholics develop high blood acetaldehyde concentrations following ethanol. To determine whether this is a specific defect in alcoholics, aldehyde dehydrogenase was studied in liver tissue obtained from ...
Kelvin R. Palmer, William J. Jenkins
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2010
The aldehyde dehydrogenase (ALDH) superfamily contains NAD(P)+-dependent enzymes that catalyze the oxidation of aldehydes to their corresponding carboxylic acids. Nineteen ALDH genes have been identified in the human genome. Mutations in these genes leading to enzyme inactivation are the molecular basis of several diseases, including Sjogren–Larsson ...
V. Vasiliou, D.R. Petersen
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The aldehyde dehydrogenase (ALDH) superfamily contains NAD(P)+-dependent enzymes that catalyze the oxidation of aldehydes to their corresponding carboxylic acids. Nineteen ALDH genes have been identified in the human genome. Mutations in these genes leading to enzyme inactivation are the molecular basis of several diseases, including Sjogren–Larsson ...
V. Vasiliou, D.R. Petersen
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2018
The aldehyde dehydrogenase superfamily contains NAD(P)+-dependent enzymes that catalyze the oxidation of aldehydes to their corresponding carboxylic acids. Nineteen aldehyde dehydrogenase genes have been identified in the human genome. Mutations in these genes that lead to enzyme inactivation are the molecular basis of several diseases, including ...
V. Vasiliou +2 more
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The aldehyde dehydrogenase superfamily contains NAD(P)+-dependent enzymes that catalyze the oxidation of aldehydes to their corresponding carboxylic acids. Nineteen aldehyde dehydrogenase genes have been identified in the human genome. Mutations in these genes that lead to enzyme inactivation are the molecular basis of several diseases, including ...
V. Vasiliou +2 more
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Betaine aldehyde dehydrogenase in plants
Plant Biology, 2009AbstractPlant betaine aldehyde dehydrogenases (BADHs) have been the target of substantial research, especially during the last 20 years. Initial characterisation of BADH as an enzyme involved in the production of glycine betaine (GB) has led to detailed studies of the role of BADH in the response of plants to abiotic stressin vivo, and the potential ...
Fitzgerald, Timothy L +2 more
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Coenzyme specificity in aldehyde dehydrogenase
Chemico-Biological Interactions, 2001Influences on coenzyme preference are explored. Lysine 137 (192 in class 1/2 ALDH) lies close to the adenine ribose, directly interacting with the adenine ribose in NAD-specific ALDHs and the 2'-phosphate of NADP in NADP-specific ALDHs. Lys-137 in class 3 ALDH interacts with the adenine ribose indirectly through an intervening water molecule.
Ingrid Kuo +3 more
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Metabolism of Cyclophosphamide by Aldehyde Dehydrogenases
1995Cyclophosphamide (Endoxan) and other oxazaphosphorines such as 4-hydroperoxy-cyclophosphamide, ifosfamide, and mafosfamide are widely used as antineoplastic drugs (Sladek, 1988; Lindahl, 1992). The cytotoxic effect is caused by alkylation reaction of these drugs with DNA and proteins inhibiting the cell proliferation.
Ulrich V. Eitzen +3 more
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Pharmacogenetics of aldehyde dehydrogenase (ALDH)
Pharmacology & Therapeutics, 1990Cette synthese aborde le metabolisme des aldehydes chez l'homme et les mammiferes, et en particulier le role de l'aldehyde deshydrogenase. Sont decrits les proprietes physicochimiques de l'enzyme, son expression genique, ses variants genetiques, son importance ...
H. Werner Goedde, Dharam P. Agarwal
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Aldehyde Dehydrogenases in Rat Liver
Canadian Journal of Biochemistry, 1972Two enzymes (I and II) with NAD+-dependent aldehyde dehydrogenase activity have been separated and partially purified from the supernatant fraction of rat liver. Resolution was effected by DEAE-cellulose column chromatography. In addition to the differences in charge properties, these two proteins differ in substrate specificity, that of enzyme II ...
G. T. Shum, A. H. Blair
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Inhibition of aldehyde dehydrogenase
1992The first two steps in the metabolism of ethanol to acetate via acetaldehyde are predominantly catalyzed by alcohol dehydrogenase and aldehyde dehydrogenase (ALDH), respectively. The efficiency of the enzymes involved in acetaldehyde disposition in humans is such that, during ethanol metabolism, blood acetaldehyde levels normally remain in the 1–2 µM ...
Peter K. Gessner, Teresa Gessner
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The Novel Aldehyde Dehydrogenase Gene, ALDH5, Encodes an Active Aldehyde Dehydrogenase Enzyme
Biochemical and Biophysical Research Communications, 1995The mRNA for the novel aldehyde dehydrogenase 5 (ALDH5) gene was detected in HuH7 hepatoma cells. The cells also expressed cytosolic aldehyde dehydrogenase (ALDH1) mRNA, but no mitochondrial aldehyde dehydrogenase (ALDH2) mRNA. Extracts of the hepatoma cells contained an enzymatic activity with an isoelectric point similar to that of ALDH1. This enzyme
K. Malek +4 more
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