Results 71 to 80 of about 329,736 (281)

Single amino acid exchanges affect the substrate preference of an acetaldehyde dehydrogenase

Applied Microbiology and Biotechnology
The NAD+-dependent aldehyde dehydrogenase AldB from Aromatoleum aromaticum was recombinantly produced in Escherichia coli and biochemically characterized.
Dominik Hege, Yvonne Gemmecker, Iris Schall, Paula Oppong-Nti, Georg Schmitt, Johann Heider   +5 more
doaj   +1 more source

Effect of the allelic variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2 on blood acetaldehyde concentrations

Human Genomics, 2009
Alcoholism is a complex behavioural disorder. Molecular genetics studies have identified numerous candidate genes associated with alcoholism. It is crucial to verify the disease susceptibility genes by correlating the pinpointed allelic variations to the
Peng Giia-Sheun, Yin Shih-Jiun
doaj   +1 more source

A ROS‐Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy

Advanced Science, EarlyView.
The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin, Jiani Li, Panqin Ma, Shinan Wu, Wenying Guan, Yimin Huang, Ke Feng, Mingyan Wei, Zixuan Yang, Shujia Guo, Caihong Huang, Yun‐Long Wu, Yi Han, Zuguo Liu   +13 more
wiley   +1 more source

ALDH2 Suppresses Ferroptosis and Promotes Bortezomib Resistance in Multiple Myeloma Through the KEAP1‐NRF2 Feedback Loop

Advanced Science, EarlyView.
ALDH2, which is overexpressed in multiple myeloma, competitively binds KEAP1 to stabilize NRF2 by blocking its ubiquitin‐proteasomal degradation. Stabilized NRF2 translocates into the nucleus to upregulate the expression of GPX4. In parallel, NRF2 binds to the ALDH2 promoter to regulate its transcription, forming a positive feedback loop that represses
Ruonan Shao, Chengcheng Liu, Xinpei Deng, Jindong Xie, Wenjian Liu, Bin Yang, Lingrui Liu, Cailu Song, Lei Li, Hua Wang, Hailin Tang   +10 more
wiley   +1 more source

Association of acute myeloid leukemia’s most immature phenotype with risk groups and outcomes

Haematologica, 2016
The precise phenotype and biology of acute myeloid leukemia stem cells remain controversial, in part because the “gold standard” immunodeficient mouse engraftment assay fails in a significant fraction of patients and identifies multiple cell-types in ...
Jonathan M. Gerber, Joshua F. Zeidner, Sarah Morse, Amanda L. Blackford, Brandy Perkins, Breann Yanagisawa, Hao Zhang, Laura Morsberger, Judith Karp, Yi Ning, Christopher D. Gocke, Gary L. Rosner, B. Douglas Smith, Richard J. Jones   +13 more
doaj   +1 more source

ALDH2 Deficiency Promotes Mitochondrial Oxidative Stress and Adverse Limb Outcomes via VDAC–HSP60 Signaling

Advanced Science, EarlyView.
ALDH2 deficiency promotes 4‐HNE accumulation, resulting in covalent modification of HSP60, disruption of its oligomeric assembly, and VDAC1‐dependent release of HSP60 from mitochondria to the cytosol. Pharmacological activation of ALDH2 preserves HSP60 proteostasis and mitochondrial integrity, whereas the clinical association between the ALDH2 rs671 ...
You‐Cheng Lin, Nan‐Chun Wu, Chon‐Seng Hong, Po‐Chao Hsu, Wen‐Jin Yang, Yi‐Cheng Chang, Che‐Hong Chen, Wei‐Ting Chang   +7 more
wiley   +1 more source

Metabolism of ethyl alcohol and the development of cancer

Alcoholism and Drug Addiction, 2018
The main metabolic pathway of ethanol elimination occurs in the liver. Ethanol is oxidised by an alcohol dehydrogenase (ADH) to a very toxic acetaldehyde. The aldehyde is converted to acetate by an aldehyde dehydrogenase (ALDH).
Wanda Dyr
doaj   +1 more source

EZpred: Improving Deep Learning‐Based Enzyme Function Prediction Using Unlabeled Sequence Homologs

Advanced Science, EarlyView.
Schematic of the EZpred pipeline, which provides high‐confidence predictions of enzyme function using a combination of sequence alignments, structural alignments, and deep learning. EZpred can be used to provide substantial increases in the richness of protein function annotations at genomic scales.
Chengxin Zhang, Quancheng Liu, Lydia Freddolino   +2 more
wiley   +1 more source

Functional Specialization of Respiratory and Olfactory Mucus Revealed by Proteomic Profiling

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Mucus overlies the nasal mucosa in the respiratory and olfactory regions, which perform distinct physiological functions. However, proteomic differences between respiratory mucosa (RM) and olfactory cleft (OC) mucus remain unclear.
Anna Kristina Hernandez, Karoline Lantzsch, Romain Topalian, Nadine Gunder, Philipp Hubel, Katharina Schindowski, Jens Pfannstiel, Thomas Hummel   +7 more
wiley   +1 more source

Supplementary Figure 1 from Targeting Aldehyde Dehydrogenase Cancer Stem Cells in Ovarian Cancer

, 2010
Supplementary Figure 1 from Targeting Aldehyde Dehydrogenase Cancer Stem Cells in Ovarian ...
Rebecca L. Stone (214799), Charles N. Landen (6898217), Alpa M. Nick (14888571), Robert C. Bast (2196820), Nicolas B. Jennings (15042230), Lance D. Miller (8444226), Gabriel Lopez-Berestein (149712), Pablo Vivas Mejia (15042227), Ashwini A. Katre (8712561), Adam D. Steg (14984405), Anil K. Sood (149701), Robert L. Coleman (14667236), David M. Gershenson (14873307), Blake Goodman (15042224)   +13 more
core   +1 more source