Results 71 to 80 of about 113,809 (301)

Expression of aldehyde dehydrogenase after neoadjuvant chemotherapy is associated with expression of hypoxia-inducible factors 1 and 2 alpha and predicts prognosis in locally advanced breast cancer

Clinics, 2013
OBJECTIVE: To analyze the expression of hypoxia-inducible factors (hypoxia-inducible factor 1A and hypoxia-inducible factor 2A) and aldehyde dehydrogenase proteins in patients with locally advanced breast carcinoma who were subjected to neoadjuvant ...
Daniel Guimarães Tiezzi, Willian Simões Clagnan, Larissa Raquel Mouro Mandarano, Christiani Bisinoto de Sousa, Heitor Ricardo Cosiski Marana, Marcelo Guimarães Tiezzi, Jurandyr Moreira de Andrade   +6 more
doaj  

Single amino acid exchanges affect the substrate preference of an acetaldehyde dehydrogenase

Applied Microbiology and Biotechnology
The NAD+-dependent aldehyde dehydrogenase AldB from Aromatoleum aromaticum was recombinantly produced in Escherichia coli and biochemically characterized.
Dominik Hege, Yvonne Gemmecker, Iris Schall, Paula Oppong-Nti, Georg Schmitt, Johann Heider   +5 more
doaj   +1 more source

Update on the aldehyde dehydrogenase gene (ALDH) superfamily

Human Genomics, 2011
Members of the aldehyde dehydrogenase gene (ALDH) superfamily play an important role in the enzymic detoxification of endogenous and exogenous aldehydes and in the formation of molecules that are important in cellular processes, like retinoic acid ...
Jackson Brian, Brocker Chad, Thompson David C, Black William, Vasiliou Konstandinos, Nebert Daniel W, Vasiliou Vasilis   +6 more
doaj   +1 more source

Integrating gene and protein expression data with genome-scale metabolic networks to infer functional pathways [PDF]

, 2013
This article has been made available through the Brunel Open Access Publishing Fund. Copyright @ 2013 Pey et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://
Beasley, JE, Pey, J, Planes, FJ, Rubio, A, Valgepea, K   +4 more
core   +1 more source

Covalent Reprogramming of Kinase Binders to Modulate Protein Abundance

Advanced Science, EarlyView.
Electrophilic remodeling of a broad‐spectrum kinase binder reveals how subtle chemical changes reprogram protein fate. An acrylamide analog of a multi‐kinase binder selectively stabilizes Aurora kinase A (AURKA) by suppressing its ubiquitination, while a short‐linker variant converts this stabilizer into a degrader.
Chen Mozes, Xiaokang Jin, Miguel A. Campos, Chen Zhou, Xiaoyu Zhang   +4 more
wiley   +1 more source

Elektroenzymatische CO2‐Fixierung

Angewandte Chemie, EarlyView.
Die elektroenzymatische CO2‐Fixierung ermöglicht eine energieeffiziente, hochselektive Synthese komplexer Moleküle. Um ihr volles Potenzial auszuschöpfen, ist ein grundlegendes Verständnis von elektrodengekoppelten Reduktasen und Carboxylasen erforderlich.
Leonardo Castañeda‐Losada, Michael Richter, Christophe Léger, Vincent Fourmond, Nicolas Plumeré   +4 more
wiley   +1 more source

Novel essential role of ethanol oxidation genes at low temperature revealed by transcriptome analysis in the antarctic bacterium pseudomonas extremaustralis [PDF]

, 2015
Temperature is one of the most important factors for bacterial growth and development. Cold environments are widely distributed on earth, and psychrotolerant and psychrophilic microorganisms have developed different adaptation strategies to cope with the
Gómez Lozano, Maria, López, Nancy Irene, Molin, Søren, Raiger Iustman, Laura Judith, Ricardi, Martiniano María, Solar Venero, Esmeralda Clara, Tribelli, Paula Maria   +6 more
core   +4 more sources

Distinct Connectivity and Functionality of Aldehyde Dehydrogenase 1a1-Positive Nigrostriatal Dopaminergic Neurons in Motor Learning

Cell Reports, 2019
Summary: Parkinson’s disease causes the most profound loss of the aldehyde dehydrogenase 1A1-positive (ALDH1A1+) nigrostriatal dopaminergic neuron (nDAN) subpopulation.
Junbing Wu, Justin Kung, Jie Dong, Lisa Chang, Chengsong Xie, Ahsan Habib, Sarah Hawes, Nannan Yang, Vivian Chen, Zhenhua Liu, Rebekah Evans, Bo Liang, Lixin Sun, Jinhui Ding, Jia Yu, Sara Saez-Atienzar, Beisha Tang, Zayd Khaliq, Da-Ting Lin, Weidong Le, Huaibin Cai   +20 more
doaj   +1 more source

Solution structure of a bacterial microcompartment targeting peptide and its application in the construction of an ethanol bioreactor [PDF]

, 2014
Targeting of proteins to bacterial microcompartments (BMCs) is mediated by an 18-amino-acid peptide sequence. Herein, we report the solution structure of the N-terminal targeting peptide (P18) of PduP, the aldehyde dehydrogenase associated with the 1,2 ...
Brown, Ian R., Frank, Stefanie, Howard, Mark J., Lawrence, Andrew D., Lee, Matthew J., Mulvihill, Daniel P., Newnham, Sarah, Prentice, Michael B., Rowe, Michelle L., Warren, Martin J., Xue, Wei-Feng   +10 more
core   +1 more source

Electroenzymatic CO2 Fixation

Angewandte Chemie International Edition, EarlyView.
Electroenzymatic CO2 fixation enables energy‐efficient, highly selective synthesis of complex molecules. Unlocking its full potential requires fundamental understanding of electrode‐coupled reductases and carboxylases. This review critically discusses available enzymes, product scope, and key thermodynamic and kinetic considerations, highlighting ...
Leonardo Castañeda‐Losada, Michael Richter, Christophe Léger, Vincent Fourmond, Nicolas Plumeré   +4 more
wiley   +1 more source