Results 81 to 90 of about 135 (134)

The causative role of amyloidosis in the cardiac complications of Alzheimer's disease: a comprehensive systematic review

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker, James Andrew, Mastitskaya Svetlana   +2 more
wiley   +1 more source

Temporal Profiling of Male Cortical Astrocyte Transcription Predicts Molecular Shifts From Early Development to Aging

Glia, Volume 73, Issue 7, Page 1349-1364, July 2025.
Main Points Comprehensive analysis of cortical astrocyte gene expression across the lifespan. Profiling dynamic changes of key astrocyte genes reveals functional shifts. Astrocytes contribute to gene‐length‐dependent transcription decline in the aging brain.
Xiaoran Wei, Jiangtao Li, Michelle L. Olsen   +2 more
wiley   +1 more source

Multifaceted Role of Microbiota‐Derived Indole‐3‐Acetic Acid in Human Diseases and Its Potential Clinical Application

The FASEB Journal, Volume 39, Issue 11, 15 June 2025.
The complexity of indole‐3‐acetic acid's (IAA's) role in human health and disease. IAA is a multifaceted compound with significant consequences for several physiological and pathological processes. ABSTRACT Indole‐3‐acetic acid (IAA) is recognized as a common plant growth hormone.
Nargis Shaheen, Jiaxing Miao, Boyu Xia, Yutong Zhao, Jing Zhao   +4 more
wiley   +1 more source

Heat Stress‐Mediated Multi‐Organ Injury: Pathophysiology and Treatment Strategies

Comprehensive Physiology, Volume 15, Issue 3, June 2025.
Thermal environment‐mediated pathophysiologic processes in the body and their coping strategies. ABSTRACT With global warming in recent years, humans have been subjected to the impact of thermal environments on both work and life. Improving the body's ability to withstand heat is an urgent task.
Xiaoqing Ding, Binghong Gao
wiley   +1 more source

Immune Reconstitution after Haploidentical Hematopoietic Stem Cell Transplantation with Different Non‐T‐Cell Depletion Protocols

MedComm, Volume 6, Issue 6, June 2025.
This review examines immune reconstitution dynamics after haploidentical hematopoietic stem cell transplantation using different non‐T‐cell depletion protocols, including the Beijing and Baltimore protocols. It summarizes the reconstitution patterns of immune cell subsets and their correlation with posttransplant complications like relapse, GVHD, and ...
Xiao‐Di Ma, Zheng‐Li Xu, Xiao‐Jun Huang   +2 more
wiley   +1 more source

Characteristic, Regulation and Targeting Strategies of Cancer Stem Cells and Their Niche in Digestive System Tumors

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Cancer stem cells, characterized by self‐renewal, differentiation, heterogeneity, plasticity and tumorigenicity, are regulated by intrinsic factors such as signaling pathways, transcription factors, metabolism and noncoding RNAs, as well as environmental cells (including tumor cells, immune cells and stromal cells), environmental factors and distant ...
Zhenzhen Chen, Huanle Qi, Yapeng Xue, Yaqi Zhang, Zhuo Zhang, Shun Xu, Shixin Liao, Xiaoyu Zeng, Jiayi Wu, Xinrui Lv, Qiankun He, Pingping Zhu   +11 more
wiley   +1 more source

Genome editing in maize and sorghum: A comprehensive review of CRISPR/Cas9 and emerging technologies

The Plant Genome, Volume 18, Issue 2, June 2025.
Abstract The increasing changes in the climate patterns across the globe have deeply affected food systems where unparalleled and unmatched challenges are created. This jeopardizes food security due to an ever‐increasing population. The extreme efficiency of C4 crops as compared to C3 crops makes them incredibly significant in securing food safety.
Mercy Jocyline Namata, Jingyi Xu, Ephrem Habyarimana, Sudhakar Reddy Palakolanu, Lihua Wang, Jieqin Li   +5 more
wiley   +1 more source

Implications for soluble iron accumulation, oxidative stress, and glial glutamate release in motor neuron death associated with sporadic amyotrophic lateral sclerosis

Neuropathology, Volume 45, Issue 3, Page 177-201, June 2025.
Oxidative stress in sporadic amyotrophic lateral sclerosis (ALS) has been evidenced by accumulation of oxidatively modified products of nucleic acids, lipids, sugars, and proteins in the motor neuron system of brains and spinal cords obtained at autopsy from the patients.
Noriyuki Shibata, Ikuko Kataoka, Yukinori Okamura, Kumiko Murakami, Yoichiro Kato, Tomoko Yamamoto, Kenta Masui   +6 more
wiley   +1 more source

Elucidating the enzyme network driving Amaryllidaceae alkaloids biosynthesis in Leucojum aestivum

Plant Biotechnology Journal, Volume 23, Issue 6, Page 1988-2005, June 2025.
Schematic representation of Amaryllidaceae alkaloid biosynthesis in Leucojum aestivum. Norbelladine synthase (LaNBS) and noroxomaritidine/norcraugsodine reductase (LaNRII) catalyze the condensation of tyramine and 3,4‐dihydroxybenzaldehyde to form norbelladine, which is subsequently O‐methylated by norbelladine‐4′‐O‐methyltransferase (LaN4′OMT ...
Basanta Lamichhane, Sarah‐Eve Gélinas, Natacha Merindol, Manoj Koirala, Karen Cristine Gonçalves dos Santos, Hugo Germain, Isabel Desgagné‐Penix   +6 more
wiley   +1 more source

Plant genetic transformation: achievements, current status and future prospects

Plant Biotechnology Journal, Volume 23, Issue 6, Page 2034-2058, June 2025.
Summary Regeneration represents a fundamental biological process wherein an organism's tissues or organs repair and replace themselves following damage or environmental stress. In plant systems, injured tree branches can regenerate adventitious buds and develop new crowns through propagation techniques like cuttings and canopy pruning, while transgenic
Peilin Wang, Huan Si, Chenhui Li, Zhongping Xu, Huiming Guo, Shuangxia Jin, Hongmei Cheng   +6 more
wiley   +1 more source