Results 31 to 40 of about 195,221 (99)
A Comparative Study of Aldehyde Oxidase from Tumorous-Head and Oregon-R-C Strains of Drosophila Melanogaster [PDF]
, 1977 Aldehyde oxidase has been partially purified from Oregon-R-C and tuh(ASU) strains of Drosophila melanogaster using an affinity technique. The two enzymes were subjected to a partial kinetic analysis and found to be very similar to one another.
Respess, Richard A.
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, 2005 NoBackground/Aims: The oxidation of xenobiotic-derived aromatic aldehydes with freshly prepared liver slices has not been previously reported. The present investigation compares the relative contribution of aldehyde oxidase, xanthine oxidase and aldehyde
Panoutsopoulos, Georgios I. +5 more
core +1 more source
The impact of single nucleotide polymorphisms on human aldehyde oxidase [PDF]
, 2012 Aldehyde oxidase (AO) is a complex molybdo-flavoprotein that belongs to the xanthine oxidase family. AO is active as a homodimer, and each 150-kDa monomer binds two distinct [2Fe2S] clusters, FAD, and the molybdenum cofactor.
Hartmann, Tobias +9 more
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A Simple Litmus Test for Aldehyde Oxidase Metabolism of Heteroarenes
, 2015 The bioavailability of aromatic azaheterocyclic drugs can be affected by the activity of aldehyde oxidase (AO). Susceptibility to AO metabolism is difficult to predict computationally and can be complicated in vivo by differences between species. Here we
Alfin D. N. Vaz (172262) +7 more
core +1 more source
Investigation of aldehyde oxidase and xanthine oxidoreductase in rainbow trout (Oncorhynchus mykiss) [PDF]
Molybdo-flavoenzymes (MFEs), aldehyde oxidase (AOX) and xanthine oxidoreductase (XOR) are involved in the oxidation of N-heterocyclic compounds and aldehydes, many of which are environmental pollutants, drugs and vitamins.
Aburas, Omaro A Emhmed
core +2 more sources
, 2005 The aim of the present study was to investigate the interaction of quinolinic acid (QA) with partially purified guinea pig liver aldehyde oxidase in terms of superoxide anion production (O2.), hydrogen peroxide (H2O2) formation and the overall substrate ...
Mohamed A. Al-Omar
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CPT: Pharmacometrics & Systems PharmacologyAbstractAldehyde oxidase (AO) contributes to the clearance of many approved and investigational small molecule drugs, which are often dual substrates of AO and drug‐metabolizing enzymes such as cytochrome P450s (CYPs). As such, the lack of established framework for quantitative translation of the clinical pharmacologic correlates of AO‐mediated ...
Nihan Izat +15 more
openaire +4 more sources
Widespread cellular distribution of aldehyde oxidase in human tissues found by immunohistochemistry staining [PDF]
, 2011 Aldehyde oxidase (EC 1.2.3.1) is a xenobiotic metabolizing enzyme that catalyzes a variety of organic aldehydes and N-heterocyclic compounds. However, its precise pathophysiological function in humans, other than its xenobiotic metabolism, remains ...
Tsutsumi, Z. +4 more
core +1 more source
, 2005 Phenylacetaldehyde is formed when the xenobiotic and biogenic amine 2-phenylethylamine is inactivated by a monoamine oxidase-catalyzed oxidative deamination. Exogenous phenylacetaldehyde is found in certain foodstuffs such as honey, cheese, tomatoes, and
Panoutsopoulos, G.I.
core