Results 61 to 70 of about 195,221 (99)
Some of the next articles are maybe not open access.
Cyclodextrin Aldehydes are Oxidase Mimics
ChemBioChem, 2009AbstractCyclodextrins containing 6‐aldehyde groups were found to catalyse oxidation of aminophenols in the presence of hydrogen peroxide. The catalysis followed Michaelis–Menten kinetics and is related to the catalysis previously observed with cyclodextrin ketones.
Fenger, Thomas Hauch +2 more
openaire +3 more sources
Identification of aldehyde oxidase 1 and aldehyde oxidase homologue 1 as dioxin-inducible genes
Toxicology, 2005Aldehyde oxidases are a family of highly related molybdo-flavoenzymes acting upon a variety of compounds of industrial and medical importance. We have identified aldehyde oxidase 1 (AOX1) as a 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) inducible gene in the mouse hepatoma cell line Hepa-1.
Enrico Garattini, Mineko Terao
exaly +3 more sources
Metabolism of Xenobiotics by Aldehyde Oxidase
Current Protocols in Toxicology, 2015AbstractAldehyde oxidase (AO) is a cytosolic molybdoflavoprotein whose contribution to the metabolism and clearance of xenobiotics‐containing heterocyclic rings has attracted increased interest in recent years. This unit details methods for identification and confirmation of AO as a metabolic pathway as well as a method for estimating clearance of ...
Deepak, Dalvie, Michael, Zientek
openaire +2 more sources
A comparison of the specificities of xanthine oxidase and aldehyde oxidase
Archives of Biochemistry and Biophysics, 1972Abstract This study directly compares the specificities of the structurally similar hydroxylating enzymes, aldehyde oxidase and xanthine oxidase. Michaelis-Menten constants for a variety of substrates of xanthine oxidase were in general lower than those of aldehyde oxidase. With respect to the rates of oxidation, the basic similarity was a preference
T A, Krenitsky +3 more
openaire +2 more sources
Liver aldehyde oxidase: A form of xanthine oxidase
Biochimica et Biophysica Acta, 1960Abstract Pig liver aldehyde oxidase is not specific for aldehydes, but in addition catalyzes the oxidation at reduced rates of hypoxanthine, xanthine and DPNH. The sites of binding of acetaldehyde and hypoxanthine by the enzyme appear to be different.
R P, IGO, B, MACKLER
openaire +2 more sources
Liver aldehyde oxidase and xanthine oxidase genetics in the mouse
Animal Blood Groups and Biochemical Genetics, 1981SummaryA ‘null’ activity variant for the major liver isozyme of aldehyde oxidase (AOX‐1) in adult male mice and an electrophoretically distinct, high activity variant of the second liver isozyme (AOX‐2) were used to examine the segregation of the genetic loci encoding these enzymes (Aox‐1 and Aox‐2 respectively) in breeding studies.
HOLMES, RS, LEIJTEN, LR, DULEY, JA
openaire +3 more sources
The purification and properties of aldehyde oxidase
Biochimica et Biophysica Acta, 1962Abstract 1. 1. Highly purified aldehyde oxidase has been prepared from pig liver by reverse ammonium sulphate fractionation, heat treatment and chromatography on DEAE- cellulose and hydroxyl-apatite. 2. 2. Although pure by electrophoresis the enzyme shows several minor components in the ultracentrifuge. The flavin content is 5 mμmoles/mg, and
openaire +2 more sources
Structure and function of mammalian aldehyde oxidases
Archives of Toxicology, 2016Mammalian aldehyde oxidases (AOXs; EC1.2.3.1) are a group of conserved proteins belonging to the family of molybdo-flavoenzymes along with the structurally related xanthine dehydrogenase enzyme. AOXs are characterized by broad substrate specificity, oxidizing not only aromatic and aliphatic aldehydes into the corresponding carboxylic acids, but also ...
Terao, Mineko +7 more
openaire +3 more sources
Journal of Medicinal Chemistry, 1980
Fourteen phosphorylated acetals and aldehydes were synthesized for testing in vitro as inhibitors or substrates of aldehyde oxidase, an enzyme involved in the conversion of aldophosphamide to inactive carboxyphosphamide, and for concurrent in vivo administration with cyclophosphamide to mice bearing L1210 ascites tumor cells.
L A, Cates +7 more
openaire +2 more sources
Fourteen phosphorylated acetals and aldehydes were synthesized for testing in vitro as inhibitors or substrates of aldehyde oxidase, an enzyme involved in the conversion of aldophosphamide to inactive carboxyphosphamide, and for concurrent in vivo administration with cyclophosphamide to mice bearing L1210 ascites tumor cells.
L A, Cates +7 more
openaire +2 more sources
Inhibition of xanthine oxidase by various aldehydes
Biochemistry, 1984The inactivation of bovine milk xanthine oxidase by various aldehydes has been investigated. For each aldehyde, the inactivation reaction gives rise to a unique molybdenum(V) electron paramagnetic resonance signal from xanthine oxidase (the Inhibited signal). Of the aldehydes tested, only a few (mainly aromatic) failed to undergo this reaction.
F F, Morpeth, R C, Bray
openaire +2 more sources