Pleiotropic Actions of Aldehyde Reductase (AKR1A) [PDF]
Metabolites, 2021 We provide an overview of the physiological roles of aldehyde reductase (AKR1A) and also discuss the functions of aldose reductase (AKR1B) and other family members when necessary.
Junichi Fujii +3 more
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Construction of Recombinant Saccharomyces cerevisiae with Ethanol and Aldehydes Tolerance via Overexpression of Aldehyde Reductase [PDF]
Microorganisms, 2022 Furfural and hydroxy-methyl-furfural (HMF) are produced by lignocellulosic biomass during heat or acid pretreatment and are toxic to yeast. Aldehyde reductase is the main enzyme to reduce furfural and HMF.
Nileema R. Divate +3 more
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Tolerance to Glutaraldehyde in Escherichia coli Mediated by Overexpression of the Aldehyde Reductase YqhD by YqhC [PDF]
Frontiers in Microbiology, 2021 Glutaraldehyde is a widely used biocide on the market for about 50 years. Despite its broad application, several reports on the emergence of bacterial resistance, and occasional outbreaks caused by poorly disinfection, there is a gap of knowledge on the ...
Beatriz Merchel Piovesan Pereira +7 more
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Crystal structures and kinetic studies of a laboratory evolved aldehyde reductase explain the dramatic shift of its new substrate specificity [PDF]
IUCrJ, 2023 The Fe2+-dependent E. coli enzyme FucO catalyzes the reversible interconversion of short-chain (S)-lactaldehyde and (S)-1,2-propanediol, using NADH and NAD+ as cofactors, respectively.
Shruthi Sridhar +8 more
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Rhodanine-3-acetamide derivatives as aldose and aldehyde reductase inhibitors to treat diabetic complications: synthesis, biological evaluation, molecular docking and simulation studies [PDF]
BMC Chemistry, 2021 In diabetes, increased accumulation of sorbitol has been associated with diabetic complications through polyol pathway. Aldose reductase (AR) is one of the key factors involved in reduction of glucose to sorbitol, thereby its inhibition is important for ...
Mohsinul Mulk Bacha +8 more
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Dealing with aflatoxin B1 dihydrodiol acute effects: Impact of aflatoxin B1-aldehyde reductase enzyme activity in poultry species tolerant to AFB1 toxic effects. [PDF]
PLoS ONE, 2020 Aflatoxin B1 aldehyde reductase (AFAR) enzyme activity has been associated to a higher resistance to the aflatoxin B1 (AFB1) toxicity in ethoxyquin-fed rats.
Hansen Murcia, Gonzalo J Diaz
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Localization of aldose and aldehyde reductase in the kidney [PDF]
Kidney International, 1989 The distribution of NADPH-dependent reductase activity in the rat cortex, outer medulla and inner medulla was investigated through biochemical and histochemical methods. Biochemical studies revealed reductase activity to be present in all three regions of the kidney with the highest specific activity observed in the inner medulla, followed by the ...
Terubayashi, Hirofumi +4 more
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Are glutathionylated aldehyde reductases the missing piece of the “catecholaldehyde hypothesis” in Parkinson's disease? A medical hypothesis concerning the detoxification of 4-hydroxynonenal (HNE) and 3,4-dihydroxyphenylacetaldehyde (DOPAL) [PDF]
Redox BiologyThe autotoxicity of the monoamine oxidase (MAO) reaction product 3,4-dihydroxyphenylacetaldehyde (DOPAL) is central to the “catecholaldehyde hypothesis”, which posits that interactions between DOPAL and the protein α-synuclein contribute to the ...
Rossella Rotondo +11 more
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Metabolic Detoxification of Glucose and 4-Hydroxynonenal in Human Neuroblastoma Cell Models [PDF]
AntioxidantsBackground: Neuroblastoma (NB) progression is influenced by metabolic and redox adaptations. The polyol pathway, driven by aldose reductase (AKR1B1) and sorbitol dehydrogenase (SORD), is activated in hyperglycemic conditions, while detoxification of ...
Martina Avanatti +7 more
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Unraveling the metabolic potential and roles of reductases in the omicsynin biosynthetic gene cluster [PDF]
Natural Products and BioprospectingOmicsynins are a group of pseudo-tetrapeptides produced by Streptomyces sp. 1647, which exhibited potent anti-influenza A virus and anti-coronavirus activities. However, its biosynthesis mechanism of C-terminus reduction remains unknown. In this work, we
Yihong Li +8 more
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