Toward aldehyde and alkane production by removing aldehyde reductase activity in Escherichia coli. [PDF]
Metab Eng, 2014 Rodriguez GM, Atsumi S.
europepmc +4 more sources
Unraveling the metabolic potential and roles of reductases in the omicsynin biosynthetic gene cluster [PDF]
Natural Products and BioprospectingOmicsynins are a group of pseudo-tetrapeptides produced by Streptomyces sp. 1647, which exhibited potent anti-influenza A virus and anti-coronavirus activities. However, its biosynthesis mechanism of C-terminus reduction remains unknown. In this work, we
Yihong Li +8 more
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Metabolic Detoxification of Glucose and 4-Hydroxynonenal in Human Neuroblastoma Cell Models [PDF]
AntioxidantsBackground: Neuroblastoma (NB) progression is influenced by metabolic and redox adaptations. The polyol pathway, driven by aldose reductase (AKR1B1) and sorbitol dehydrogenase (SORD), is activated in hyperglycemic conditions, while detoxification of ...
Martina Avanatti +7 more
doaj +2 more sources
Aldose and aldehyde reductase exhibit isocorticosteroid reductase activity. [PDF]
European Journal of Biochemistry, 1983 In this paper we describe the reduction of corticosteroid metabolites containing the 17 beta-aldol side chain (isocorticosteroids) by aldose and aldehyde reductase from human tissues. Aldose reductase catalyzed the reduction of the aldehydes derived from cortisol and corticosterone at about the same rate, whereas aldehyde reductase preferentially acted
B. Wermuth, C. Monder
semanticscholar +3 more sources
Are glutathionylated aldehyde reductases the missing piece of the “catecholaldehyde hypothesis” in Parkinson's disease? A medical hypothesis concerning the detoxification of 4-hydroxynonenal (HNE) and 3,4-dihydroxyphenylacetaldehyde (DOPAL) [PDF]
Redox BiologyThe autotoxicity of the monoamine oxidase (MAO) reaction product 3,4-dihydroxyphenylacetaldehyde (DOPAL) is central to the “catecholaldehyde hypothesis”, which posits that interactions between DOPAL and the protein α-synuclein contribute to the ...
Rossella Rotondo +11 more
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Antioxidants, 2023 Diabetic retinopathy (DR) is a complication of diabetes mellitus that can lead to vision loss and blindness. It is driven by various biochemical processes and molecular mechanisms, including lipid peroxidation and disrupted aldehyde metabolism, which ...
Burak Mugdat Karan +4 more
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Electrochemical Biosensing of Glucose Based on the Enzymatic Reduction of Glucose
Sensors, 2022 In this work, the enzyme aldehyde reductase, also known as aldose reductase, was synthesized and cloned from a human gene. Spectrophotometric measurements show that in presence of the nicotinamide adenine dinucleotide phosphate cofactor (NADPH), the ...
Thomas Soranzo +8 more
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Біологія тварин, 2022 The research was conducted to study the activity of aldehyde dehydrogenase (EC 1.2.1.3) and aldehyde reductase (EC 1.1.1.21), the levels of TBA reactive substances and protein carbonyl derivates in the cytosolic fraction of rat liver under the conditions
O. M. Voloshchuk, T. V. Luchyk
doaj +1 more source
Engineered Corynebacterium glutamicum as the Platform for the Production of Aromatic Aldehydes
Frontiers in Bioengineering and Biotechnology, 2022 Aromatic aldehydes, including 4-hydroxybenzaldehyde (4-HB aldehyde), protocatechuic (PC) aldehyde, and vanillin, are used as important flavors, fragrances, and pharmaceutical precursors and have several biological and therapeutic effects.
Hyun-Song Kim +6 more
doaj +1 more source
Characterization of the novel ene reductase Ppo-Er1 from paenibacillus polymyxa [PDF]
, 2020 Ene reductases enable the asymmetric hydrogenation of activated alkenes allowing the manufacture of valuable chiral products. The enzymes complement existing metal- and organocatalytic approaches for the stereoselective reduction of activated C=C double ...
Aregger, David +2 more
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