Results 201 to 210 of about 436,306 (274)

Structure of porcine aldehyde reductase holoenzyme

Nature Structural Biology, 1995
Aldehyde reductase, a member of the aldo-keto reductase superfamily, catalyzes the NADPH-dependent reduction of a variety of aldehydes to their corresponding alcohols. The structure of porcine aldehyde reductase-NADPH binary complex has been determined by x-ray diffraction methods and refined to a crystallographic R-factor of 0.20 at 2.4 A resolution ...
O, el-Kabbani, K, Judge, S L, Ginell, D A, Myles, L J, DeLucas, T G, Flynn   +5 more
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Characterization of aldehyde reductase of Sporobolomyces salmonicolor

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1992
An NADPH-dependent aldehyde reductase (EC 1.1.1.2) isolated from Sporobolomyces salmonicolor AKU 4429 was further characterized. The enzyme also catalyzed the reductions of D-glucuronate, D-glucose, D-xylose and D-galactose at high concentrations. Km values for D-glucuronate and D-glucose are 345 and 4270 mM, respectively.
M, Kataoka, H, Sakai, T, Morikawa, M, Katoh, T, Miyoshi, S, Shimizu, H, Yamada   +6 more
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Characterization of aldose reductase and aldehyde reductase from rat testis

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1989
Aldose reductase (alditol:NAD(P)+ 1-oxidoreductase, EC 1.1.1.21) and aldehyde reductase (alcohol:NADP+ oxidoreductase, EC 1.1.1.2) were purified to a homogeneity from rat testis. The molecular weights of aldose reductase and aldehyde reductase were estimated to be 38,000 and 41,000 by SDS-polyacrylamide gel electrophoresis, and the pI values of these ...
N, Kawasaki, T, Tanimoto, A, Tanaka
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Sulfoxide reductase activity of liver aldehyde oxidase

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1983
The present study provides evidence that guinea pig and rabbit liver aldehyde oxidase (EC 1.2.3.1) in the presence of its electron donors such as aldehydes or N-heterocyclic compounds functions as a sulfoxide reductase towards sulindac and other sulfoxide compounds.
K, Tatsumi, S, Kitamura, H, Yamada
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Identification of long chain specific aldehyde reductase and its use in enhanced fatty alcohol production in E. coli.

Metabolic Engineering, 2016
Z. Fatma, Kamran Jawed, Anu Jose Mattam, S. Yazdani   +3 more
semanticscholar   +3 more sources

YMR152W from Saccharomyces cerevisiae encoding a novel aldehyde reductase for detoxification of aldehydes derived from lignocellulosic biomass.

Journal of Bioscience and Bioengineering, 2020
Aldehydes are the main inhibitors generated during the pretreatment of lignocellulosic biomass, which can inhibit cell growth and disturb subsequent fermentation.
Y. Ouyang, Qian Li, Xiaolin Kuang, Hanyu Wang, Jinjian Wu, E. Ayepa, Huan Chen, Getachew Tafere Abrha, Zhengyue Zhang, Xi Li, Menggen Ma   +10 more
semanticscholar   +1 more source

Structure of aldehyde reductase in ternary complex with a 5-arylidene-2,4-thiazolidinedione aldose reductase inhibitor.

European Journal of Medicinal Chemistry, 2010
V. Carbone, M. Giglio, R. Chung, T. Huyton, J. Adams, R. Maccari, R. Ottanà, A. Harã, O. El-Kabbani   +8 more
semanticscholar   +3 more sources

Inhibition of aldehyde reductase by aldose reductase inhibitors

Biochemical Pharmacology, 1990
A broad group of structurally diverse aldose reductase inhibitors including flavonoids, carboxylic acids and hydantoins, have been examined for their ability to inhibit rat kidney aldehyde reductase (EC 1.1.1.19, EC 1.1.1.20) versus rat lens aldose reductase (EC 1.1.1.21).
S, Sato, P F, Kador
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Identification of Pig Brain Aldehyde Reductases with the High‐Km Aldehyde Reductase, the Low‐Km Aldehyde Reductase and Aldose Reductase, Carbonyl Reductase, and Succinic Semialdehyde Reductase

Journal of Neurochemistry, 1985
Abstract: Four NADPH‐dependent aldehyde reductases (ALRs) isolated from pig brain have been characterized with respect to substrate specificity, inhibition by drugs, and immunological criteria. The major enzyme, ALR1, is identical in these respects with the high‐Km aldehyde reductase, glucuronate reductase, and tissue‐specific, e.g., pig kidney ...
J A, Cromlish, T G, Flynn
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Human kidney aldose and aldehyde reductases

Journal of Diabetes and its Complications, 1993
Mounting experimental evidence links increased aldose reductase activity with diabetes-related kidney functional changes. To investigate the interrelationship of NADPH-dependent reductases in the human kidney, both aldose reductase and aldehyde reductase were purified from human kidney by a series of chromatographic procedures, including gel filtration
S, Sato, P F, Kador
openaire   +2 more sources