Results 21 to 30 of about 41,156 (268)
PLoS ONE, 2016 Aldolase has been implicated as a protein coupling the actomyosin motor and cell surface adhesins involved in motility and host cell invasion in the human malaria parasite Plasmodium falciparum. It binds to the cytoplasmic domain (CTD) of type 1 membrane
Suraya A Diaz +6 more
doaj +1 more source
Promiscuity‐Guided Enzyme Evolution via Substrate Multiplexed Screening
Angewandte Chemie, EarlyView.Through historical context and recent examples, this Minireview summarizes the strengths, limitations, and practical considerations for the implementation of substrate multiplexed screening (SUMS) in enzyme evolution. ABSTRACT An enzyme's ability to react with diverse substrates while maintaining high yield and selectivity, termed “substrate ...
Holly A. Weilbaker +3 more
wiley +2 more sources
Frontiers in Bioengineering and Biotechnology, 2019 Glycolic acid is a two-carbon α-hydroxy acid with many applications in industrial sectors including packaging, fine chemistry, cosmetics, and pharmaceutics. Currently, glycolic acid is chemically manufactured from fossil resources.
Cléa Lachaux +9 more
doaj +1 more source
Aldolase B knockdown prevents high glucose-induced methylglyoxal overproduction and cellular dysfunction in endothelial cells. [PDF]
PLoS ONE, 2012 We used cultured endothelial cells as a model to examine whether up-regulation of aldolase B and enhanced methylglyoxal (MG) formation play an important role in high glucose-induced overproduction of advanced glycosylation endproducts (AGEs), oxidative ...
Jianghai Liu +5 more
doaj +1 more source
Clinical Chemistry, 1969 Abstract Two commercial kits for the measurement of serum aldolase activity by a spectrophotometric (UV) method were evaluated. Neither was satisfactory in their present forms, since aldolase activity was not rate-limiting in one, and side reactions utilizing NADH occurred in the other.
Alex Kaplan +2 more
openaire +1 more source
A Revised Model for Muscarine Biosynthesis Involving Lysine Trimethylation
Angewandte Chemie, EarlyView.The fatal mushroom toxin l‐(+)‐muscarine is one of the most prominent natural products. We elucidated its biosynthetic origin in the sweating mushroom Collybia rivulosa based on incorporation of stable isotope‐labeled compounds and extensive mass spectrometric analyses.
Sebastian Dörner +4 more
wiley +2 more sources
Malaria Journal, 2011 Background Counts of malaria parasites in peripheral blood are important to assess severity of Plasmodium falciparum malaria. Thin and thick smears are routinely used for this purpose. Methods In this study the Binax NOW® Malaria Test, an easy-to-perform
Jacobs Jan +6 more
doaj +1 more source
Investigation into the Mode of Phosphate Activation in the 4-Hydroxy-4-Methyl-2-Oxoglutarate/4-Carboxy-4-Hydroxy-2-Oxoadipate Aldolase from Pseudomonas putida F1. [PDF]
PLoS ONE, 2016 The 4-hydroxy-4-methyl-2-oxoglutarate (HMG)/4-carboxy-4-hydroxy-2-oxoadipate (CHA) aldolase is the last enzyme of both the gallate and protocatechuate 4,5-cleavage pathways which links aromatic catabolism to central cellular metabolism.
Scott Mazurkewich, Stephen Y K Seah
doaj +1 more source
Angewandte Chemie, EarlyView.Amino‐bearing silsesquioxanes are water‐stable nanozymes that exhibit aggregation‐ and disaggregation‐dependent catalysis and can be applied to intracellular prodrug activation for cancer therapy. ABSTRACT Synthetic nanozymes have emerged as promising alternatives to natural enzymes for catalytic and therapeutic applications, yet their limited ...
Rabia Zahid +4 more
wiley +2 more sources
The mechanism of calcium-induced inhibition of muscle fructose 1,6-bisphosphatase and destabilization of glyconeogenic complex. [PDF]
PLoS ONE, 2013 The mechanism by which calcium inhibits the activity of muscle fructose 1,6-bisphosphatase (FBPase) and destabilizes its interaction with aldolase, regulating glycogen synthesis from non-carbohydrates in skeletal muscle is poorly understood.
Dariusz Rakus +5 more
doaj +1 more source