Results 11 to 20 of about 41,156 (268)
Multifunctional Fructose 1,6-Bisphosphate Aldolase as a Therapeutic Target
Frontiers in Molecular Biosciences, 2021 Fructose 1,6-bisphosphate aldolase is a ubiquitous cytosolic enzyme that catalyzes the fourth step of glycolysis. Aldolases are classified into three groups: Class-I, Class-IA, and Class-II; all classes share similar structural features but low amino ...
David B. Pirovich +2 more
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Molecules, 2022 Enzyme immobilization is a technology that enables (bio-)catalysts to be applied in continuous-flow systems. However, there is a plethora of immobilization methods available with individual advantages and disadvantages. Here, we assessed the influence of
Martin Wäscher +2 more
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Fish allergens at a glance: Variable allergenicity of parvalbumins, the major fish allergens
Frontiers in Immunology, 2014 Fish is a common trigger of severe, food-allergic reactions. Only a limited number of proteins induce specific IgE-mediated immune reactions. The major fish allergens are the parvalbumins.
Annette eKuehn +5 more
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Shift of the reaction equilibrium at high pressure in the continuous synthesis of neuraminic acid
Beilstein Journal of Organic Chemistry, 2022 The importance of a compound that helps fight against influenza is, in times of a pandemic, self-evident. In order to produce these compounds in vast quantities, many researchers consider continuous flow reactors in chemical industry as next stepping ...
Jannis A. Reich +5 more
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Engineering aldolases as biocatalysts [PDF]
Current Opinion in Chemical Biology, 2014 Aldolases are seen as an attractive route to the production of biologically important compounds due to their ability to form carbon-carbon bonds. However, for many industrial reactions there are no naturally occurring enzymes, and so many different engineering approaches have been used to address this problem.
Windle +4 more
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Recent Progress in the Development of Diagnostic Tests for Malaria
Diagnostics, 2017 The impact of malaria on global health has continually prompted the need to develop effective diagnostic strategies. In malaria endemic regions, routine diagnosis is hampered by technical and infrastructural challenges to laboratories. These laboratories
Francis D. Krampa +3 more
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Structures, characteristics and functions of fructose-1,6-bisphosphate aldolase in various tissues
Acta Societatis Botanicorum Poloniae, 2023 Aldolase exhibits multiple functions in a variety of organisms, including fungi, unicellular algae and plants, and so on. Furthermore, different isoforms of fructose 1,6-bisphosphate aldolase (FBA) exhibit significantly different characteristics and ...
Lina Yang +4 more
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LOXL2-dependent deacetylation of aldolase A induces metabolic reprogramming and tumor progression
Redox Biology, 2022 Lysyl-oxidase like-2 (LOXL2) regulates extracellular matrix remodeling and promotes tumor invasion and metastasis. Altered metabolism is a core hallmark of cancer, however, it remains unclear whether and how LOXL2 contributes to tumor metabolism.
Ji-Wei Jiao +15 more
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Non-classical Protein Excretion Is Boosted by PSMα-Induced Cell Leakage
Cell Reports, 2017 Release of cytoplasmic proteins into the supernatant occurs both in bacteria and eukaryotes. Because the underlying mechanism remains unclear, the excretion of cytoplasmic proteins (ECP) has been referred to as “non-classical protein secretion.” We show ...
Patrick Ebner +7 more
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A thermolabile aldolase A mutant causes fever-induced recurrent rhabdomyolysis without hemolytic anemia. [PDF]
PLoS Genetics, 2014 Aldolase A deficiency has been reported as a rare cause of hemolytic anemia occasionally associated with myopathy. We identified a deleterious homozygous mutation in the ALDOA gene in 3 siblings with episodic rhabdomyolysis without hemolytic anemia ...
Asmaa Mamoune +17 more
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