The Network Basis for the Structural Thermostability and the Functional Thermoactivity of Aldolase B [PDF]
Molecules, 2023 Thermostability is important for the thermoactivity of proteins including enzymes. However, it is still challenging to pinpoint the specific structural factors for different temperature thresholds to initiate their specific structural and functional ...
Guangyu Wang
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Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca2+ release from the ER [PDF]
iScience, 2022 Summary: Uncoupling protein 2 (UCP2), a mitochondrial protein, is known to be upregulated in pancreatic islets of patients with type 2 diabetes (T2DM); however, the pathological significance of this increase in UCP2 expression is unclear.
Ryota Inoue +19 more
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Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex. [PDF]
PLoS Biology, 2020 Loss of hepatic fructose-1, 6-bisphosphate aldolase B (Aldob) leads to a paradoxical up-regulation of glucose metabolism to favor hepatocellular carcinogenesis (HCC), but the upstream signaling events remain poorly defined. Akt is highly activated in HCC,
Xuxiao He +10 more
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Aldolase B-driven lactagenesis and CEACAM6 activation promote cell renewal and chemoresistance in colorectal cancer through the Warburg effect [PDF]
Cell Death and Disease, 2023 Colorectal cancer (CRC) is a prevalent malignancy worldwide and is associated with a high mortality rate. Changes in bioenergy metabolism, such as the Warburg effect, are often observed in CRC.
Yu-De Chu +5 more
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PCR primers for an aldolase-B intron in acanthopterygian fishes [PDF]
BMC Evolutionary Biology, 2001 Background Nuclear DNA sequences provide genetic information that complements studies using mitochondrial DNA. Some 'universal' primer sets have been developed that target introns within protein-coding loci, but many simultaneously amplify introns from ...
Jones William J +2 more
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Characterization of the Aldolase B Intronic Enhancer [PDF]
Journal of Biological Chemistry, 1998 The aldolase B gene is transcribed at a high level in the liver, kidney, and small intestine. This high level of gene expression results from cooperation between a weak but liver-specific promoter and an intronic activator. A deletional study of this activator present in the first intron allowed us to ascribe the maximal enhancer function to a 400-base
C, Gregori +4 more
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Human monoclonal antibody recognizing liver-type aldolase B [PDF]
Biochemical Journal, 1986 A human hybridoma clone (4E3) has been established by fusing lymphocytes from a lymph node taken from a breast cancer patient and human lymphoblastoid cells, LICR-LON-HMy2, by the poly(ethylene glycol) method. 4E3 has been stabilized and continued to secrete IgMk antibody into culture medium (greater than 10 micrograms/ml) for over 1 year.
N, Hibi +4 more
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In Vivo Functional Characterization of the Aldolase B Gene Enhancer [PDF]
Journal of Biological Chemistry, 2002 A 400-bp intronic enhancer fragment in conjunction with the proximal promoter of the aldolase B gene provided correct tissue-specific expression in transgenic mice together with hormonal regulation in the liver. We investigated in vivo and in cultured cells the contribution of the intronic regulatory sequences and their interaction with the promoter ...
Claudine, Gregori +4 more
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Loss of glomerular aldolase B in diabetic nephropathy promotes renal fibrosis via activating Akt/GSK/β-catenin axis [PDF]
Journal of Advanced ResearchObjective: Diabetic nephropathy (DN), characterized by a complex and multifaceted pathogenesis, stands as the foremost catalyst behind end-stage renal disease (ESRD).
Minghui Liu +9 more
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Identification and evaluation of fructose-bisphosphate aldolase B as a potential diagnostic biomarker in choledochal cysts patients: a quantitative proteomic analysis. [PDF]
Transl Pediatr, 2021 Ming G, Guo W, Cheng Y, Wang J.
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