Aldolase B Overexpression is Associated with Poor Prognosis and Promotes Tumor Progression by Epithelial-Mesenchymal Transition in Colorectal Adenocarcinoma [PDF]
Cellular Physiology and Biochemistry, 2017 Background: Glycolysis is considered to be the root of cancer development and progression, which involved a multi-step enzymatic reaction. Our study aimed at figuring out which glycolysis enzyme participates in the development of colorectal cancer and ...
Qingguo Li +6 more
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ALDOB (aldolase B, fructose-bisphosphate) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on ALDOB (aldolase B, fructose-bisphosphate), with data on DNA, on the protein encoded, and where the gene is implicated.
Peng, SY, Hsu, HC
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Replication of the rat aldolase B locus differs between aldolase B‐expressing and non‐expressing cells [PDF]
FEBS Letters, 2001 We previously reported a rat chromosomal origin of DNA replication (oriA1) that encompassed the aldolase B (AldB) gene promoter. Here, we examined utilization of oriA1 in AldB‐expressing and non‐expressing cells. The results suggested the occurrence of mutually exclusive regulation between DNA replication and transcription.
Miyagi, Satoru +4 more
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Dietary and hormonal regulation of aldolase B gene expression. [PDF]
Journal of Clinical Investigation, 1985 Aldolase B is an enzyme of the glycolytic pathway whose activity and mRNA levels in the liver fluctuate according to dietary status. Both the enzyme activity and the mRNA concentration decline during fasting and increase four- to eightfold upon refeeding of a carbohydrate-rich diet. The mechanism, however, of the mRNA induction remains unknown.
A, Munnich +6 more
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Identification of dehydrogenase, hydratase, and aldolase responsible for the propionyl residue removal in degradation of cholic acid C-17 side chain in Comamonas testosteroni TA441 [PDF]
Microbiology SpectrumBacterial steroid degradation is gaining attention for its diverse roles, such as Mycobacterium tuberculosis’s reliance on the degradation of the C17 side chain of cholesterol for survival in host environments.
Masae Horinouchi
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Journal of Cellular Physiology, 2004 AbstractThe expression of aldolase A and B isoenzyme transcripts was confirmed by RT‐PCR in rat kidney and their cell distribution was compared with characteristic enzymes of the gluconeogenic and glycolytic metabolic pathway: fructose‐1,6‐bisphosphatase (FBPase), phosphoenol pyruvate carboxykinase (PEPCK), and pyruvate kinase (PK).
Yanez, AJ +9 more
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Fructosuria and recurrent hypoglycemia in a patient with a novel c.1693T>A variant in the 3′ untranslated region of the aldolase B gene [PDF]
SAGE Open Medical Case Reports, 2019 Hereditary fructose intolerance, caused by mutations in the ALDOB gene, is an unusual cause of hypoglycemia. ALDOB encodes the enzyme aldolase B, responsible for the hydrolysis of fructose 1-phosphate in the liver.
Martha Catalina Morales-Alvarez +4 more
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Pan-cancer analysis of aldolase B gene as a novel prognostic biomarker for human cancers. [PDF]
Medicine (Baltimore), 2023 Zhao N, Xu H.
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Characterization of the chicken aldolase B gene.
Journal of Biological Chemistry, 1985 Vertebrates possess three isozyme forms of fructose diphosphate aldolase. We have isolated two overlapping chicken genomic clones which encode the liver-specific form of this enzyme; we have identified the 5' and 3' ends of this gene by a combination of primer extension analysis and S1 mapping; and we have determined the entire nucleotide sequence of ...
D G, Burgess, E E, Penhoet
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Asymmetric Conjugate Hydrocyanation of α,β-Unsaturated Aldehydes Catalyzed by Engineered 2-Deoxy-D-ribose-5-phosphate Aldolase. [PDF]
ChemistryThe power of catalytic promiscuity: The enantioselective conjugate hydrocyanation of enals remains a long‐standing challenge for biocatalysis. Here, we report the redesign of 2‐deoxy‐D‐ribose‐5‐phosphate aldolase for the asymmetric conjugate hydrocyanation of aromatic enals, expanding the reaction scope of iminium‐based enzyme catalysis to include an ...
Zhou H, Fodran P, Fu H, Poelarends GJ.
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