Lysine-Cysteine-Serine-Tryptophan Inserted into the DNA-Binding Domain of Human Mineralocorticoid Receptor Increases Transcriptional Activation by Aldosterone [PDF]
arXivDue to alternative splicing in an ancestral DNA-binding domain (DBD) of the mineralocorticoid receptor (MR), humans contain two almost identical MR transcripts with either 984 amino acids (MR-984) or 988 amino acids (MR-988), in which their DBDs differ by only four amino acids, Lys,Cys,Ser,Trp (KCSW).
arxiv
A Study of the Mechanism of Secretion of the Sodium-Retaining Hormone (Aldosterone)12 [PDF]
, 1957 John H. Laragh, H. C. Stoerk
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Biomarkers in heart failure: Traditional and emerging indicators for prognosis
ESC Heart Failure, EarlyView.
Arnold Péter Ráduly +4 more
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Predicting right ventricular failure after left ventricular assist device implant: A novel approach
ESC Heart Failure, EarlyView.Abstract Aims Right ventricular (RV) failure (RVF) after left ventricular assist device (LVAD) implant is an important cause of morbidity and mortality. Modern, data‐driven approaches for defining and predicting RVF have been under‐utilized. Methods Two hundred thirty‐two patients were identified with a mean age of 55 years; 40 (17%) were women, 132 ...
Carissa E. Livingston +6 more
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Poor communication impairs optimal care of patients with heart failure and erectile dysfunction
ESC Heart Failure, EarlyView.Abstract Aims Heart failure (HF) and erectile dysfunction (ED) share numerous risk factors and pathogenetic mechanisms, resulting in a high prevalence of ED among male patients with HF. This questionnaire‐based study aimed to better understand the patient's journey from a patient perspective and that of healthcare professionals (HCPs) regarding ...
Lea Leist, Lenka Hausmann, Carla Pohlink
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Contemporary management of pain in cirrhosis: Toward precision therapy for pain
Hepatology, EarlyView., 2022 Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman +4 more
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Brazilian Journal of Medical and Biological Research, 1997 In view of the importance of the intestine in the osmoregulation of freshwater fishes, we determined the effects of oxytocin, urotensin II (UII), and aldosterone added to the serosal side of the isolated posterior intestine of the freshwater-adapted ...
B. Baldisserotto, O.M. Mimura
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Comparison of Transcriptional Activation by Corticosteroids of Human MR (Ile-180) and Human MR Haplotype (Ile180Val) [PDF]
arXivWhile the classical function of human mineralocorticoid receptor (MR) is to regulate sodium and potassium homeostasis through aldosterone activation of the kidney MR, the MR also is highly expressed in the brain, where the MR is activated by cortisol in response to stress. Here, we report the half-maximal response (EC50) and fold-activation by cortisol,
arxiv
ADJUSTMENT TO ALDOSTERONE OR DESOXYCORTICOSTERONE ACETATE INDUCED SODIUM RETENTION IN PATIENTS WITH ADDISON'S DISEASE * [PDF]
, 1959 J. T. August, Don H. Nelson
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ESC Heart Failure, EarlyView.Abstract Heart failure with preserved ejection fraction (HFpEF) is defined by heart failure (HF) with a left ventricular ejection fraction (LVEF) of at least 50%. HFpEF has a complex and heterogeneous pathophysiology with multiple co‐morbidities contributing to its presentation. Establishing the diagnosis of HFpEF can be challenging.
Roy Rasalam +4 more
wiley +1 more source