Results 81 to 90 of about 3,518 (200)
Abstract The spatial and energetic encoding of allosteric regulatory sites remains a major challenge in structural biology, frequently representing a “blind spot” for sequence‐based artificial intelligence (AI) models. We present a protein language model (PLM)‐guided approach complemented by the energy landscape frustration analysis as a dual‐stream ...
Will Gatlin +8 more
wiley +1 more source
Abstract The accurate prediction of antibody–antigen (AbAg) complexes is a key challenge for computational immunology, with applications in therapeutic antibody design and diagnostics. Current deep learning methods have the potential to generate high‐confidence AbAg structures.
Joakim Nøddeskov Clifford +1 more
wiley +1 more source
Probables casos de alergia endocrínea
Objeto. Por respecto a una terminología utilizada por autores de indiscutible valor, repetimos en este trabajo la expresión "Alergia Endócrina", pero dejamos constancia de que, en nuestra opinión, no es adecuada para referirse a fenómenos alérgicos en ...
Miguel Agustín Solari +2 more
doaj
Though drive efficiency was highly influential to model outcomes, such parameters will likely be known prior to any experimental gene drive introductions. We conclude that understanding the ecological and life‐history characteristics specific to target populations will be critical to accurately predict gene drive outcomes and inform risk assessments ...
Matthew A. Combs +5 more
wiley +1 more source
Improving Malaria Parasite Gene Flow Inference Under Sparse Spatial Sampling
ABSTRACT Estimating malaria parasite migration is crucial for informing elimination strategies, particularly by identifying regions with higher parasite migration that may serve as transmission sources and intervention targets. Methods that infer spatial variations in gene flow from georeferenced genetic data, including Estimated Effective Migration ...
Yao Li +4 more
wiley +1 more source
Prevalência de Alergias numa escola do 1.º ciclo do distrito de Braga
Introdução: As alergias afetam de forma significativa a qualidade de vida das crianças e das suas famílias. A Direção-Geral da Saúde (DGS) indica, que entre as mais comuns se encontram as alergias alimentares em cerca de 5% das crianças.
Daniela Gonçalves +5 more
doaj +1 more source
Incidence and Early‐Life Risk Factors for Food Allergy in a Spanish Birth Cohort
ABSTRACT Aim The prevalence of food allergy has increased in recent decades. We aimed to determine the cumulative incidence of food allergy in early childhood and to identify associated risk factors. Methods We conducted a prospective birth cohort study including 1006 newborns recruited over one year at a single hospital in Spain and followed until 4 ...
Jorge García‐Ezquiaga +6 more
wiley +1 more source
Background and Purpose Long‐lasting cognitive deficits after surgery in aged individuals, referred to as perioperative neurocognitive disorder (NCD), are a significant public health concern. Such postoperative cognitive deficits are dependent on the presence of microglia in the brain, which, when activated, trigger neuroinflammation.
Jinrui Lyu +9 more
wiley +1 more source
Here, we demonstrate that polysaccharide chain length regulation plays a distinct role in enabling formation of a cyclic molecule important for the bacterial cell surface. However, this function is necessary, but not sufficient for the cyclic molecule's biosynthesis.
Joseph F. Carr +4 more
wiley +1 more source

