Identification of the nucleolar localization signal in <i>Autographa californica</i> multiple nucleopolyhedrovirus multifunctional protein Ac16. [PDF]
Chen G +5 more
europepmc +1 more source
Enhancing Maturation of Human Neuromuscular Organoids via Electrical Stimulation
A framework for on‐demand and non‐invasive exposure of human neuromuscular organoids (NMOs) to electrical stimuli is established to promote their maturation. The robustness and effectiveness of different stimulation regimes are evaluated via thorough characterization of organoid tissue structure and contraction capacity. Chronic electrical stimulation,
Chrysanthi‐Maria Moysidou +12 more
wiley +1 more source
DPY30 Is an Epigenetic Decoupler Linking Replication Stress to Immunoediting in Pancreatic Cancer. [PDF]
Citron F +42 more
europepmc +1 more source
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong +24 more
wiley +1 more source
Correction: Two-Year Outcomes for the Active and Healthy Families Pediatric Obesity Group Intervention for Families in an Emerging Latinx Community: a Mixed Methods Study. [PDF]
La Charite J +10 more
europepmc +1 more source
ANKS1B in the nucleus accumbens plays a critical role in the transition from controlled to escalated cocaine intake. Mechanistically, ANKS1B interacts with CBP to epigenetically suppress FoxO3 through H3K27 acetylation. The ANKS1B‐CBP‐FoxO3 signaling cascade presents a novel theraputic target for the treatment of cocaine addiction.
Liping Yang +15 more
wiley +1 more source
Methodology for human-induced pluripotent stem cell-derived excitatory and inhibitory neuron coculture with astrocytes for Alzheimer's disease modelling. [PDF]
Li J +7 more
europepmc +1 more source
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun +7 more
wiley +1 more source
HAK-actin, a U-ExM-compatible probe to image the actin cytoskeleton. [PDF]
Mercey O +9 more
europepmc +1 more source

