TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes
Advanced Science, EarlyView.In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang +11 more
wiley +1 more source
Palmitoyltransferase DHHC7 mediates protein palmitoylation and is essential for sperm function through the modulation of [Ca<sup>2+</sup>]<sub>i</sub> and ROS signaling. [PDF]
Front Cell Dev BiolZheng H +8 more
europepmc +1 more source
Engineering Murine Cross-Reactivity Into an Affibody to Human Death Receptor 5. [PDF]
Biotechnol BioengKuo TH, Vunnam N, Sachs JN, Hackel BJ.
europepmc +1 more source
KANK2 at focal adhesions regulates their maintenance and dynamics, while at fibrillar adhesions it influences cell migration via microtubule-dependent mechanism. [PDF]
Cell Commun SignalStojanović N +8 more
europepmc +1 more source
The Selective DHCR24 Blocker SH42 Inhibits ACE2 Binding and Cellular Entry of SARS-CoV-2 Spike Proteins More Efficiently Than Atorvastatin. [PDF]
Research (Wash D C)Kovacs T +10 more
europepmc +1 more source
The chaperone DNAJB6b halts amyloid formation through association with transient Aβ oligomers.
Phys Chem Chem PhysGetachew J +5 more
europepmc +1 more source