Results 81 to 90 of about 16,484,276 (296)
In Defense of Wishful Thinking: James, Quine, Emotions, and the Web of Belief [PDF]
, 2018 What is W. V. O. Quine’s relationship to classical pragmatism? Although he resists the comparison to William James in particular, commentators have seen an affinity between his “web of belief” model of theory confirmation and James’s claim that our ...
Klein, Alexander
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Advanced Science, 2023 Creating a cellular model of Alzheimer's disease (AD) that accurately recapitulates disease pathology has been a longstanding challenge. Recent studies showed that human AD neural cells, integrated into three‐dimensional (3D) hydrogel matrix, display key
Matthias Hebisch +6 more
doaj +1 more source
Reviews in Cardiovascular Medicine, 2022 Background: It is clinically widely overlooked that many patients with Marfan- (MFS) or Loeys-Dietz-Syndrome (LDS) are obese. While anthropometric routine parameters are not very suitable, the modern Bioelectrical Impedance Analysis (BIA) seems superior ...
Sebastian Freilinger +12 more
doaj +1 more source
Dying without Dignity: Homeless Deaths in Los Angeles County: 2000 - 2007 [PDF]
, 2007 This report is an investigation into 2,815 homeless deaths in Los Angeles County between January, 2000 and May, 2007, based on statistics provided by the Los Angeles County Coroner's office.
Bob Erlenbusch +3 more
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Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Olfactory Bulb Hyperplasia in Genetically Confirmed Infantile Alexander Disease [PDF]
Journal of Clinical and Diagnostic Research, 2019 Alexander Disease (AxD) is a well-known leukodystrophy with characteristic findings on brain Magnetic Resonance Imaging (MRI) including bilaterally symmetric, frontal confluent white matter signal abnormality with relative sparing of the parietal and ...
Michael Todd Jurkiewicz +3 more
doaj +1 more source
Complement Activation in Patients With Probable Systemic Lupus Erythematosus and Ability to Predict Progression to American College of Rheumatology-Classified Systemic Lupus Erythematosus. [PDF]
, 2020 ObjectiveTo evaluate the frequency of cell-bound complement activation products (CB-CAPs) as a marker of complement activation in patients with suspected systemic lupus erythematosus (SLE) and the usefulness of this biomarker as a predictor of the ...
Alexander, Roberta Vezza +12 more
core +2 more sources
Area Postrema Syndrome as the Initial Presentation of Alexander Disease
Neurology, 2021 A 16-year-old boy presented with 6 years evolution of anorexia, failure to thrive, nocturnal vomiting, and dysphagia. He was exhaustively explored. Neurologic examination was normal except hoarse voice. MRI revealed a hyperintensity of the area postrema (
F. Renaldo +4 more
semanticscholar +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source