Results 21 to 30 of about 267,329 (233)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Este artigo tem como objetivo apreender as práticas de gestão adotadas a partir do planejamento estratégico, estabelecendo as prioridades de atuação em cada área.
Marcos Ribeiro Cunha, Lúcia Kratz
doaj +1 more source
ErB4 and NdB4 nanostructured powders are produced by mechanochemical synthesis. 5 h mechanical alloying and 4 M HCl acid leaching are used in the production. ErB4 and NdB4 powders exhibit maximum magnetization of 0.4726 emu g−1 accompanied with an antiferromagnetic‐to‐paramagnetic phase transition at about TN = 18 K and 0.132 emu g−1 with a maximum at ...
Burçak Boztemur +5 more
wiley +1 more source
Alfa-Cakes-Fabrik, Radebul-Dresden
ALFA-CAKES-FABRIK, RADEBUL-DRESDEN Alfa-Cakes-Fabrik, Radebul-Dresden ( -
Alfa-Cakes-Fabrik
core +3 more sources
Despite benefits to storage stability and handleability of aluminum scrap, octadecyl phosphonic acid (ODPA) SAMs reduce the tensile strength of wires produced using friction‐induced recycling. Etching and methyl diphosphonic acid (MDPA) coatings, however, have little effect.
Timothy D. Goller +3 more
wiley +1 more source
Pressure‐Assisted Dimensional Transformation of 2D Hydrogenated Borophene into 0D Boron Quantum Dots
Hydrogenated borophene (HB) is transformed into distinct boron nanostructures through a solvent‐free thermal process. Under flowing nitrogen, hydrogen escape promotes reconstruction into B2O3 nanoplatelets, whereas hydrogen‐induced pressure under sealed conditions facilitates fragmentation into boron quantum dots.
Ozden Gunes Yildiz +11 more
wiley +1 more source
Perfil sociodemográfico da leishmaniose tegumentar americana em Almenara – Minas Gerais
Objetivo: caracterizar o perfil sociodemográfico da LTA no município de Almenara – MG entre os anos de 2016-2018, considerando-se dados da notificação oficial fornecidos pelo setor de vigilância do município.
Djully Borges da Silva Araújo +4 more
doaj +1 more source
Forward‐Biased Perovskite Photodiodes for In‐Sensor Optical Change Sensing
A forward‐biased perovskite photodiode is introduced as an in‐sensor analog preprocessing unit that uses current balancing between photocurrent and injection current to generate optical changes relative to programmable optical reference levels. The device directly converts reference‐relative optical changes into bipolar current signals, enabling sensor‐
Eungseon Yeon +14 more
wiley +1 more source

