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Alfentanil in Anesthesia and Analgesia

Drug Intelligence & Clinical Pharmacy, 1986
Alfentanil is a tetrazole derivative of fentanyl. Many of the pharmacologic effects of alfentanil are similar to those of fentanyl and sufentanil, but of quicker onset than those of fentanyl and of shorter duration than those of fentanyl and sufentanil.
exaly   +3 more sources

Prevention of propofol-induced pain in children: combination of alfentanil and lidocaine vs alfentanil or lidocaine alone [PDF]

open access: yesBritish Journal of Anaesthesia, 2009
BACKGROUND: Pain from a propofol injection is a common side-effect in paediatric patients. This prospective, randomized, double-blind study evaluated the efficacy of a combined pretreatment of alfentanil with lidocaine on the incidence and severity of ...
Kwak, HJ   +7 more
exaly   +2 more sources

Alfentanil kinetics in the elderly

Clinical Pharmacology and Therapeutics, 1984
Alfentanil disposition after an intravenous bolus of 50 micrograms/kg was followed in 15 elderly surgical patients and was compared to that in nine young adults. A two-compartment open model described alfentanil disappearance from plasma. Apparent volumes of distribution of the central compartment (201 and 211 ml/kg; means), at steady state (460 and ...
H, Helmers   +4 more
openaire   +2 more sources

The Pharmacokinetics of Alfentanil in Children

Anesthesiology, 1987
The pharmacokinetics of alfentanil were studied in 18 children (3 months to 14 yr of age) undergoing surgery. Alfentanil was administered as a 30-s infusion of either 50 or 120 micrograms.kg-1. Pharmacokinetic values were independent of dose. There was no correlation between Vdss (Volume of distribution at a steady state, measured as l.kg-1) and age or
G V, Goresky   +4 more
openaire   +2 more sources

Pharmacokinetics of intranasal alfentanil

Journal of Clinical Anesthesia, 1995
To determine the pharmacokinetics of intranasal and intravenous (IV) administrations of alfentanil in 10 healthy volunteers.Randomized, prospective, double-blind, placebo-controlled, cross-over trial with at least one week between the two modes of administration.Healthy volunteers at a university medical center.10 healthy, nondrug-dependent volunteers ...
R, Schwagmeier   +3 more
openaire   +2 more sources

Pharmacokinetics of Alfentanil in Man

Anesthesia & Analgesia, 1982
The distribution and elimination kinetics of alfentanil, a new short-acting analgesic, were studied in five surgical patients. Its behavior, following a bolus injection of 120 micrograms/ml, was compatible with a three-compartment open-model distribution. The disappearance of the drug from plasma was rapid (t 1/2 pi = 3.5 +/- 1.3 minutes, t 1/2 alpha =
F, Camu   +3 more
openaire   +2 more sources

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