Pharmacokinetics, pharmacodynamics, and safety of ciprofol emulsion in Chinese subjects with normal or impaired renal function [PDF]
Frontiers in Pharmacology, 2023 Background: Ciprofol, a novel sedative–hypnotic drug, has been approved for its use in inducing and maintaining general anesthesia, as well as for providing sedation.Methods: In this phase I, single-center, parallel, controlled, open-label clinical trial,
Jun Tao +11 more
exaly +5 more sources
Age-related reduction in ciprofol requirement for loss of consciousness during anesthesia induction: a prospective cohort study [PDF]
Frontiers in MedicineBackgroundCiprofol, a novel intravenous anesthetic for procedural sedation and general anesthesia, characterized by rapid onset of action, lower rates of injection pain and effective sedation at lower doses, is a promising alternative to propofol ...
Yu-Gang Lu +6 more
doaj +2 more sources
Frontiers in Pharmacology, 2022 Background and Purpose: Ciprofol (HSK3486), a novel 2,6-disubstituted phenol derivative, is a new intravenous anesthetic compound with a similar chemical structure to propofol.
Yunzhao Yang +5 more
exaly +3 more sources
A chronopharmacological comparison of ciprofol and propofol: focus on sedation and side effects [PDF]
Frontiers in Molecular NeurosciencePropofol is a commonly used intravenous anesthetic in clinical practice, while ciprofol, a propofol derivative, also targets GABAA receptors with enhanced anesthetic potency.
Xuehan Li +11 more
doaj +3 more sources
ED50 of ciprofol combined with different doses of remifentanil during upper gastrointestinal endoscopy in school-aged children: a prospective dose-finding study using an up-and-down sequential allocation method [PDF]
Frontiers in PharmacologyObjectiveThis study aimed to determine the 50% effective dose (ED50) of ciprofol when combined with different doses of remifentanil for upper gastrointestinal endoscopy of school-age children and to evaluate its safety.MethodsThis study involved school ...
Xu Zhang +4 more
doaj +3 more sources
Population pharmacokinetics of a single bolus of ciprofol in Chinese pediatric patients [PDF]
BMC AnesthesiologyBackground Ciprofol is a recently developed sedative similar to propofol, but there is a lack of bolus pharmacokinetic data for ciprofol in children.
Sicong Wang +7 more
doaj +2 more sources
Frontiers in Pharmacology, 2022 Objective: Ciprofol is a novel 2,6-disubstituted phenol derivative that has improved pharmacokinetic and pharmacodynamic properties compared with propofol.
Bin Wu +5 more
exaly +3 more sources
Journal of International Medical Research, 2022 Ciprofol is a novel intravenous anesthetic agent and a highly selective gamma-aminobutyric acid-A receptor agonist, similar to propofol. This is the first report about ciprofol overdose occurring during the maintenance phase of anesthesia for a surgical ...
Mengchang Yang
exaly +2 more sources
Ciprofol injection in patients receiving non-invasive positive pressure ventilation: a retrospective study [PDF]
Frontiers in PharmacologyObjectThis study aims to compare the efficacy and safety of ciprofol versus propofol in sedation for patients undergoing non-invasive positive pressure ventilation (NPPV), with a focus on evaluating sedative efficiency and systematically comparing the ...
DaLong Zhang +5 more
doaj +2 more sources
Pharmacology Research and Perspectives, 2023 Ciprofol is a newly developed intravenous anesthetic agent with improved pharmacokinetic properties. Compared to propofol, ciprofol exhibits stronger binding to the GABAA receptor and elicits a greater enhancement of GABAA receptor‐mediated neuronal ...
Gongchen Duan, Haiyan Lan, Yini Wu
exaly +2 more sources