Pharmacology Research and Perspectives, 2023 Ciprofol is a newly developed intravenous anesthetic agent with improved pharmacokinetic properties. Compared to propofol, ciprofol exhibits stronger binding to the GABAA receptor and elicits a greater enhancement of GABAA receptor‐mediated neuronal ...
Gongchen Duan, Ji Min Wu, Haiyan Lan
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A chronopharmacological comparison of ciprofol and propofol: focus on sedation and side effects [PDF]
Frontiers in Molecular NeurosciencePropofol is a commonly used intravenous anesthetic in clinical practice, while ciprofol, a propofol derivative, also targets GABAA receptors with enhanced anesthetic potency.
Xuehan Li +11 more
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Ciprofol injection in patients receiving non-invasive positive pressure ventilation: a retrospective study [PDF]
Frontiers in PharmacologyObjectThis study aims to compare the efficacy and safety of ciprofol versus propofol in sedation for patients undergoing non-invasive positive pressure ventilation (NPPV), with a focus on evaluating sedative efficiency and systematically comparing the ...
DaLong Zhang +5 more
doaj +3 more sources
Frontiers in Pharmacology, 2022 Background and Purpose: Ciprofol (HSK3486), a novel 2,6-disubstituted phenol derivative, is a new intravenous anesthetic compound with a similar chemical structure to propofol.
Yunzhao Yang +5 more
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The dose-dependent anesthetic effect of ciprofol on 8-week-old C57BL/6J mice [PDF]
Frontiers in PharmacologyObjectiveThe research is to explore the half effective dose (ED50) and 95% effective dose (ED95) of ciprofol with intraperitoneal injection of 8-week-old C57BL/6J adult mice, which will provide experimental basis for the reasonable dose design of ...
Huan Wang +4 more
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Age-related reduction in ciprofol requirement for loss of consciousness during anesthesia induction: a prospective cohort study [PDF]
Frontiers in MedicineBackgroundCiprofol, a novel intravenous anesthetic for procedural sedation and general anesthesia, characterized by rapid onset of action, lower rates of injection pain and effective sedation at lower doses, is a promising alternative to propofol ...
Yu-Gang Lu +6 more
doaj +2 more sources
Efficacy and Safety of Ciprofol versus Propofol for Tracheal Intubation in Pediatric Patients Undergoing Laparoscopic Hernia Repair: An Assessor-Blinded Randomised Controlled Trial [PDF]
Drug Design, Development and TherapyJieze Pan,1– 3,* Tianhao Zhong,1– 3,* Yiwen Lv,1– 3 Miao Jiang,1– 3 Lijie Fang,1– 3 Xuhui Cui,1– 3 Jie Wang,1– 3 Ruifeng Zeng1– 3 1Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children’
Pan J +7 more
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Effect of ciprofol with etomidate on the occurrence of hypotension in elderly patients undergoing upper gastrointestinal endoscopy: a prospective randomized controlled study [PDF]
BMC AnesthesiologyBackground Ciprofol is increasingly used for endoscopic sedation due to its reduced injection pain, but evidence regarding its safety when combined with etomidate in elderly patients remains limited.
Zeyu Guo +6 more
doaj +2 more sources
Drug Design, Development and TherapyLu Liu,1 Feng Li,1 Yanxia Wei,2 Li Luo,1 Li Shen,1 Jie Li,1 Ninglin Sun,1 Bin Qian,1 Dawei Sun3 1Department of Anesthesiology, The First People’s Hospital of Yancheng, Yancheng, Jiangsu, People’s Republic of China; 2Department of Cardiology, The Second ...
Liu L +8 more
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Effect of ciprofol-etomidate mixtures for deep sedation during gastrointestinal endoscopy: Protocol for a three-arm, double-blind randomized controlled trial. [PDF]
PLoS ONEIntroductionDeep sedation for gastrointestinal endoscopy can be achieved using either ciprofol or etomidate, both associated with distinct adverse events such as cardiopulmonary depression, myoclonus, and postoperative nausea and vomiting.
Boxuan Xu +9 more
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