Results 11 to 20 of about 736 (146)

Drug–drug interaction study of ciprofol and sodium divalproex: Pharmacokinetics, pharmacodynamics, and safety in healthy Chinese subjects

Clinical and Translational Science, 2023
Ciprofol (also known as HSK3486) is a promising intravenous anesthetic candidate derived from propofol and independently developed by Haisco Pharmaceutical Group Co., Ltd. (Chengdu, China). Compared with propofol, ciprofol has the potential to reduce the
Dandan Yang, Wei Zhang, Zourong Ruan, Bo Jiang, Siqi Huang, Jiaying Wang, Pengfei Zhao, Mengyue Hu, Min Yan, Honggang Lou   +9 more
doaj   +2 more sources

Incidence of injection pain between ciprofol and propofol after induction of general anesthesia: a systematic review and meta-analysis of randomized controlled trials [PDF]

Frontiers in Medicine
BackgroundPropofol and ciprofol are commonly used agents for inducing general anesthesia. Although propofol is preferred for its potent sedative effects and quick recovery, it is associated with a higher incidence of injection-related pain.
Jinfang Zeng, Guowei Zhu, Jinjin Jian, Minmin Zhu   +3 more
doaj   +4 more sources

Pharmacokinetics, pharmacodynamics, and safety of ciprofol emulsion in Chinese subjects with normal or impaired renal function [PDF]

Frontiers in Pharmacology, 2023
Background: Ciprofol, a novel sedative–hypnotic drug, has been approved for its use in inducing and maintaining general anesthesia, as well as for providing sedation.Methods: In this phase I, single-center, parallel, controlled, open-label clinical trial,
Jun Tao, Jun Tao, Shuaibing Liu, Shuaibing Liu, Ying Ying Zhao, Lei Qi, Pangke Yan, Nan Wu, Xiao Liu, Dongwei Liu, Xin Tian, Xin Tian   +11 more
doaj   +2 more sources

Population pharmacokinetics of a single bolus of ciprofol in Chinese pediatric patients

BMC Anesthesiology
Background Ciprofol is a recently developed sedative similar to propofol, but there is a lack of bolus pharmacokinetic data for ciprofol in children.
Sicong Wang, Yan Li, Zhiyan Hu, Longzhi Du, Ying Wang, Xiaoya Jiang, Lujin Li, Wangning Shangguan   +7 more
doaj   +2 more sources

A Common Neuronal Ensemble in the Lateral Habenula Regulates Ciprofol Anesthesia in Mice

Pharmaceuticals
General anesthetics were first used over 170 years ago; however, the mechanisms of how general anesthetics induce loss of consciousness (LOC) remain unclear.
Kang Zhou, Lin-Chen Zhang, He Zhu, Bei Wen, Jia-Li Tang, Ping-Chuan Yuan, A-Fang Zhu, Yu-Guang Huang   +7 more
doaj   +2 more sources

The effects of CYP2B6 inactivators on the metabolism of ciprofol.

PLoS ONE
Ciprofol is a novel short-acting intravenous anaesthetic developed in China that is mainly metabolized by cytochrome P450 2B6 (CYP2B6) and uridine diphosphate glucuronosyltransferase 1A9 (UGT1A9).
Ming Lu, Xiaorui Zhang, Wenli Li, Xiangchen Li, Shan Li, Xiaoyu Yin, Zhiqing Zhang   +6 more
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Ciprofol in Children Undergoing Adenoidectomy and Adenotonsillectomy: A Retrospective Cohort Study [PDF]

Drug Design, Development and Therapy
Chao Zeng,1,* Lu Li,1,* Mengrui Wang,2,* Jun Xiong,1 Wenjuan Pang,1 Haiyan Yu,1 Jiadi He,1 Xuguang Wang,1 Yingying Chen,1 Yanyan Sun1 1Department of Anesthesiology, Shenzhen University General Hospital, Shenzhen University, Shenzhen ...
Zeng C, Li L, Wang M, Xiong J, Pang W, Yu H, He J, Wang X, Chen Y, Sun Y   +9 more
doaj   +1 more source

The efficacy and safety of ciprofol versus propofol in patients undergoing painless hysteroscopy: a randomized, double-blind, controlled trial

BMC Anesthesiology
Background Studies have reported that ciprofol has the advantage of reducing injection pain compared to propofol during gastroscopy, colonoscopy, and fiberoptic bronchoscopy.
Aijun Li, Ning Li, Lei Zhu, Zige Xu, Yifan Wang, Junjie Li, Gerong Zhang   +6 more
doaj   +2 more sources

Comparison of the ED50 of Ciprofol Combined With or Without Fentanyl for Laryngeal Mask Airway Insertion in Children: A Prospective, Randomized, Open-Label, Dose-Response Trial [PDF]

Drug Design, Development and Therapy
Sicong Wang, Yan Li, Fang Chen, Hua-Cheng Liu, Lezhou Pan, Wangning Shangguan Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Key Laboratory of ...
Wang S, Li Y, Chen F, Liu HC, Pan L, Shangguan W   +5 more
doaj   +1 more source

Ciprofol as compared to propofol for sedation and general anesthesia: a systematic review of randomized controlled trials

Journal of Anesthesia, Analgesia and Critical Care
Background Propofol is the most commonly used hypnotic agent used during sedation and general anesthesia (GA) practice, offering faster recovery compared to benzodiazepines.
Jessica M. Currò, Cristina Santonocito, Federica Merola, Simone Messina, Marco Sanfilippo, Serena Brancati, Filippo Drago, Filippo Sanfilippo   +7 more
doaj   +2 more sources