Results 41 to 50 of about 736 (146)

Chinese Society of Pediatric Anesthesiology Guideline for Pediatric Sedation (2025)

Pediatric Anesthesia, Volume 36, Issue 7, Page 850-871, July 2026.
ABSTRACT Background With the increasing variety of pediatric diagnostic procedures, a growing number of children require sedation for diagnostic examinations. Appropriate sedation protocols guarantee the safety of children during sedation and improve its efficiency.
Xingrong Song, Dongxu Lei, Yu Cui, Zhen Du, Yingping Jia, Yue Jin, Hang Tian, Ying Xu, Lifang Yang, Jianmin Zhang, Jijian Zheng, Yunxia Zuo, Liang Zhong, John Zhong, Maryrose Osazuwa, Elizabeth Drum, Charles Dean Kurth, Yue Huang, Qinghua Huang, Heqi Liu, Wei Liu, Rui Ma, Dongpi Wang, Tingting Wang, Zixin Wang, Siwei Wei, Lei Yang, Rui Zhou, Liumei Chen, Weifeng Yu, Jun Li, Mazhong Zhang, Li Zhang, Shuangquan Qu, Shoudong Pan, Rong Wei, Liming Cheng, Yaolong Chen, Xueping Li, Zhenyu Tang   +39 more
wiley   +1 more source

Ciprofol suppresses glycolysis and EMT in colorectal cancer cells by activating APC to modulate the Wnt/β-catenin signaling pathway

Scientific Reports
Ciprofol, an innovative anesthetic derived from propofol, has not yet been studied in detail regarding its effects in colorectal cancer (CRC). This study mainly explored the effects of Ciprofol on the epithelial-mesenchymal transition (EMT) process ...
Han Wu, Jiening Gao, Yong Wang, Yao Zhang, Li Jia, Weijing Li   +5 more
doaj   +1 more source

Effect of Remimazolam on Postoperative Delirium in Surgical ICU Patients: A Single‐Center Prospective Cohort Study

Critical Care Research and Practice, Volume 2026, Issue 1, 2026.
Aim Postoperative delirium is a clinically important complication among patients admitted to a surgical intensive care unit (ICU). Remimazolam is increasingly used for perioperative and ICU sedation, but its association with postoperative delirium after elective surgery remains uncertain.
Jiajia Hong, Chengjin Zhao, Lin Lin, Alessandro Ruggiero   +3 more
wiley   +1 more source

Ciprofol suppresses proliferation, invasion and migration of human pancreatic cancer cells

Pakistan Journal of Pharmaceutical Sciences
Pancreatic cancer (PC) is heterogeneous cancer having a high death rate and poor prognosis. The perioperative variables, such as anesthetics, may affect the cancer progression. Ciprofol is an intravenous anesthetic widely used recently.
Fangfang Han, Shi Dong, Zhou Chen, Chunlu Dong, Huaqing Shi, Yan Du, Wence Zhou   +6 more
doaj   +1 more source

Myocardial Injury After Noncardiac Surgery (MINS): From Biomarker to Management—A Narrative Review

International Journal of Clinical Practice, Volume 2026, Issue 1, 2026.
Background Myocardial injury after noncardiac surgery (MINS) is defined as prognostically relevant myocardial ischemia occurring within 30 days of noncardiac surgery. Despite affecting 8%–20% of patients undergoing major noncardiac procedures, MINS remains substantially underdiagnosed because it is typically asymptomatic. The condition is independently
May Thu Kyaw, Zin Wah Lwin, Neetu Rawal
wiley   +1 more source

Alleviative Effects of Ciprofol on Hepatic Ischemia/Reperfusion Injury Through Inhibiting Macrophage Polarization

Immunity, Inflammation and Disease, Volume 13, Issue 7, July 2025.
This study investigates the protective effects of ciprofol on hepatic ischemia/reperfusion (I/R) injury, demonstrating that it reduces inflammation and apoptosis in liver tissue. Using a mouse model, ciprofol treatment was shown to suppress macrophage polarization and decrease pro‐inflammatory cytokine levels, similar to the effects observed with the ...
Hanjian Chen, Heng Wen, Dongdong Tian, Huina Su, Ru Zhang, Lijia Zhang   +5 more
wiley   +1 more source

Recovery Profiles and Well‐Being Outcomes in Patients Undergoing Various Anaesthesia Techniques: A Systematic Review

Health Science Reports, Volume 8, Issue 6, June 2025.
ABSTRACT Background and Aim An appropriate anaesthesia technique is considered for the patient's health status to ensure a painless recovery. This study explored the important role of anesthesia selection in improving recovery outcomes and patient well‐being across diverse surgical settings.
Abdullah K. Bubshait
wiley   +1 more source

ED50 of ciprofol combined with different doses of remifentanil during upper gastrointestinal endoscopy in school-aged children: a prospective dose-finding study using an up-and-down sequential allocation method

Frontiers in Pharmacology
ObjectiveThis study aimed to determine the 50% effective dose (ED50) of ciprofol when combined with different doses of remifentanil for upper gastrointestinal endoscopy of school-age children and to evaluate its safety.MethodsThis study involved school ...
Xu Zhang, Xu Zhang, Ning Zhang, Haicheng Song, Yueyi Ren   +4 more
doaj   +1 more source

ED50 of ciprofol combined with sufentanil for fiberoptic bronchoscopy of different patient populations with pulmonary tuberculosis

BMC Anesthesiology
Background Ciprofol is a promising sedative. This study aims to explore the median effective dose (ED50) of ciprofol in inhibiting responses to fiberoptic bronchoscopy in patients with pulmonary tuberculosis (PTB) of different genders and ages when ...
Min Pan, Weidong Liu, Zhixin Zhang, Tong Li, Weibin Xie   +4 more
doaj   +1 more source

Pharmacokinetics and exposure–safety relationship of ciprofol for sedation in mechanically ventilated patients in the intensive care unit

CPT: Pharmacometrics &Systems Pharmacology, Volume 13, Issue 5, Page 823-836, May 2024.
Abstract Ciprofol (HSK3486) is a newly developed, highly selective γ‐aminobutyric acid‐A (GABAA) receptor potentiator that is recently approved for a new indication of sedation for patients in the intensive care unit (ICU) in China. This analysis aimed to characterize the population pharmacokinetics (PopPKs) of ciprofol and evaluate the relationship of
Lu Liu, Kun Wang, Zhongyi Sun, Pangke Yan, Mengyue Hu, Xiao Liu, Meixia Chen, Nan Wu, Xiaoqiang Xiang   +8 more
wiley   +1 more source