Results 41 to 50 of about 5,673 (192)
Allergy, EarlyView.ABSTRACT These updated EAACI guidelines aim to standardize skin testing methodologies for both immediate and non‐immediate drug hypersensitivity reactions. For immediate reactions, the optimal testing window is 4–6 weeks post‐reaction; whereas beyond 6 months, false‐negative results increase.
Annick Barbaud +14 more
wiley +1 more source
, 2007 OBJECTIVES: (i) To evaluate the pupillary response to alfentanil as a surrogate measure of alfentanil pharmacokinetics in cirrhotic patients and to compare the data observed in cirrhotic patients with those found in healthy volunteers (historical control
Desager, Jean-Pierre +6 more
core +1 more source
British Journal of Pharmacology, EarlyView.Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux +26 more
wiley +1 more source
Drug Design, Development and Therapy, 2023 Lini Wang,* Yi Wang,* Li Ma,* Yiting Wang, Xiaoxiao Mu, Zhaoxu Huang, Ziyu Zheng, Huang Nie Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, People’s Republic of China&ast ...
Wang L +7 more
doaj
Acta Anaesthesiologica Scandinavica, Volume 70, Issue 9, October 2026.ABSTRACT Background A considerable proportion of patients in the intensive care unit (ICU) experience pain. The objective of this prospective observational cohort study was to investigate the prevalence of pain, factors associated with pain and pain trajectories in ICU patients.
Aleksandra E. Wlodarczyk‐Abou Elseoud +7 more
wiley +1 more source
Veterinární Medicína, 2015 The aim of this study was to compare the cardiovascular and respiratory effects and the bispectral scale index (BIS) as well as the recovery period characteristics in response to treatment with a propofol/alfentanil admixture of different concentrations ...
N. Jia +9 more
doaj +1 more source
Opioids in COVID-19: Two Sides of a Coin
Frontiers in Pharmacology, 2022 Introduction: The treatment of most severe COVID-19 patients included the large-scale use of sedatives and analgesics–possibly in higher doses than usual–which was reported in the literature.
Camila Vantini Capasso Palamim +9 more
doaj +1 more source
Management of Pain in the Intensive Care Unit: A Nordic Survey
Acta Anaesthesiologica Scandinavica, Volume 70, Issue 8, September 2026.ABSTRACT Background Pain is common in intensive care unit (ICU) patients with up to one‐third experiencing pain at rest and even more during mobilization and clinical procedures. This survey aimed to explore physicians' attitudes and preferences regarding pain management in adult ICU patients in the Nordic countries.
Benedikte Kollerup Madsen +37 more
wiley +1 more source
Patient-controlled alfentanil target-controlled infusion for postoperative analgesia
, 1996 We have compared the opioid effects of a patient-demand, target-controlled infusion of alfentanil (n = 10), with patient-controlled bolus administration of morphine (n = 10) following major spinal surgery in Chinese patients aged from 11 to 67 years. The
Irwin, MG
core +1 more source
British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan +3 more
wiley +1 more source