Results 61 to 70 of about 35,946 (260)

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Polysaccharide breakdown products drive degradation-dispersal cycles of foraging bacteria through changes in metabolism and motility

eLife
Most of Earth’s biomass is composed of polysaccharides. During biomass decomposition, polysaccharides are degraded by heterotrophic bacteria as a nutrient and energy source and are thereby partly remineralized into CO2.
Astrid Katharina Maria Stubbusch, Johannes M Keegstra, Julia Schwartzman, Sammy Pontrelli, Estelle E Clerc, Samuel Charlton, Roman Stocker, Cara Magnabosco, Olga T Schubert, Martin Ackermann, Glen G D'Souza   +10 more
doaj   +1 more source

Sodium Alginate‐Based Submucosal Lifting Hydrogel for Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection

Advanced Healthcare Materials, EarlyView.
A biocompatible sodium alginate‐based hydrogel is developed as a next‐generation submucosal lifting agent intended for EMR and ESD. The optimized formulation exhibits a composition devoid of endotoxins, high viscosity, demonstrates reliable injectability, and ensures prolonged mucosal elevation.
Iram Maqsood, Venkata S. Akshintala, Surya T. Evani, Rebecca A. Krimins, Yihan Wang, Keith Freel, Ahmed Ibrahim, Saowanee Ngamruengphong, Mouen Khashab, Stephen W. Hoag   +9 more
wiley   +1 more source

A Novel Perfused Full‐Thickness Human Skin Microphysiological System for Modeling Injury, Regeneration, Tumor Pathophysiology, and Therapeutics Development

Advanced Healthcare Materials, EarlyView.
What if human skin could remain fully alive and functional outside the body for weeks? A New Alternative Method (NAM) based on a vascularized full‐thickness skin microphysiological system achieves precisely this, preserving native vasculature, resident immunity, and metabolic activity for up to three weeks, while faithfully recapitulating radiation ...
Yusuf Surucu, Hamid Malekzadeh, Alexa Rivera Del Rio Hernandez, Naresh Mahajan, Ethan Banks, Dayyan Ur Rahman, José A. Arellano, Katherine S. Yang, Alexey Altman, G.V. Naveen Kumar, Matthew L. Steinhauser, Jeffrey A. Gusenoff, J. Peter Rubin, Asim Ejaz   +13 more
wiley   +1 more source

Bioprinting High‐Cell‐Density Cardiac Tissue Constructs With Sustained Contractile Function

Advanced Healthcare Materials, EarlyView.
Contractile cardiomyocytes in 3D culture provide insights into the behavior of the heart. Combining a 3D bioprinting approach with a multi‐electrode array allows the development of the 3D culture to be monitored over time, and matured cultures allow the effect of drugs on cardiac function to be modelled, replicating effects seen in clinical application.
Priscila Melo, Wing Tai Tung, Harvey Lewis, Kavin Hettiarachchilage, Babis Tzivelekis, Rolando Berlinguer‐Palmini, Ana Marina Ferreira, Jason Gill, Kenneth Dalgarno   +8 more
wiley   +1 more source

BIODEGRADATION OF PHENOL BY IMMOBILIZED PROVIDENCIA RETTGERI

Zagazig Journal of Pharmaceutical Sciences, 1997
The cells of locally isolated, phenol-degrading Providencia rettgeri strain were immobilized by either entrapment within alginate beads or adsorption on silicate solid supports; celite R-634 and sintered glass rings (siran).
Hassan Abdel-Salam
doaj   +1 more source

Biochemical Characterization of a New Oligoalginate Lyase and Its Biotechnological Application in Laminaria japonica Degradation

Frontiers in Microbiology, 2020
Oligoalginate lyases catalyze the degradation of alginate polymers and oligomers into monomers, a prerequisite for biotechnological utilizing alginate.
Shangyong Li, Shangyong Li, Linna Wang, Samil Jung, Beom Suk Lee, Ningning He, Myeong-Sok Lee   +6 more
doaj   +1 more source

A Fully Defined GelMA‐Based Matrix Allows Fine Tuning of Tissue‐Relevant Biomechanical and Biochemical Cues for Organoid Culture

Advanced Healthcare Materials, EarlyView.
A fully defined GelMA‐based ECM platform integrates tunable tissue‐relevant stiffness with laminin–entactin biochemical supplementation to support mouse small intestinal organoid growth. Coordinated control of mechanical and biochemical cues promotes robust proliferation, budding morphogenesis, differentiation, and passaging, providing a reproducible ...
Junyi Liu, Su Su Htwe, Lay Poh Tan, Yen Choo   +3 more
wiley   +1 more source

Alginic Acid Degradation by Eliminases from Abalone Hepatopancreas

Journal of Biological Chemistry, 1967
Abstract Two separate alginic acid eliminases have been purified from abalone hepatopancreas. Alginase I appeared to be specific for β-1,4 bonds involving d-mannuronic acid units and apperently acts at random on internal bonds. Alginase II appeared to cleave 1,4 bonds involving l-guluronic acid and to work at or near chain ends.
H I, Nakada, P C, Sweeny
openaire   +2 more sources

Research Progress on the Directed Enzymatic Preparation and Structure-Function Relationship of Alginate Oligosaccharides [PDF]

Shipin Kexue
Alginate oligosaccharides (AOS) are low molecular mass linear polymers containing 2–10 monosaccharides obtained by the degradation of alginate. They have various bioactivities including anti-inflammatory, antibacterial, antioxidant, antitumor, and ...
CUI Yongyan, YANG Min, LIU Nan, WANG Shanshan, SUN Yong, SUN Guohui, ZHOU Deqing
doaj   +1 more source